Peroxisome proliferator-activated receptors(PPAR) are ligand-activated nuclear transcription factors which regulate the expression of many genes.Numbers of researchs indicate PPAR exert anti-inflammatory activities by inhibiting the expression of inflammatory singal transcription passage such as NF-?B,AP-1,STAT,meanwhile preserve from acute lung injury.This review will focus on structure of PPAR and their ligand and activity regulation and antiinflammation mechanism of action and protection to acute lung injury.

There are about 170 kinds of medical plants of Commelina all over the world.Experimental studies showed that the main chemical compositions in the plants included alkaloids,flavonoids,terpenes,and sterols etc.Plants of commelina,especially commelina communis,have pharmacological activities of antibacterial,antiinflammation,resisting-oxidation,lowering-glycemia,relieving-pain and stopping-cough etc.It is necessary that their pharmacological effects and chemical compositions are further developed and investigated systematically.

Objective To explore the influence of Dan'e-Fukang soft extract on anxiety and depression of edometriosis patients.Methods 83 patients with endometriosis were randomly divided into a treatment group,treated with Dan'e-Fukang soft extract and a control group,treated with Gesrtinone capsules.Gynecological examination,pelvic B-mode ultrasonopgraphy,liver function,kidney function and CA 125 were detected before and after the treatment.The alteration of dysmenorrhea pain,menstrual blood volume,and adverse reactions were observed.Self-rating Depression Scale (SDS) and self-rating Anxiety Scale (SAS) were used to test the patients after treatment.Results ① Endometriosis effective rate of the treatment group and the control group were 95.35％ and 100.0％ respectively.② SAS and SDS score of the treatment group were (48.56± 5.39) and (50.35 ± 6.76) respectively before treatment,(33.43 ± 4.52) and (35.54± 4.68) respectively after treatment.The score of control group were (46.92±6.35) and (53.41 ±7.00) before treatment (37.56±5.64)and (42.87± 5.79) respectively after treatment.The scores had no significances between the two groups before the treatment,but had significant difference after the treatment(P＜0.05).Conclusion Dan'e-Fukang soft extract has exact effects on endometriosis,and its effects on mood are partly independent from endomet riosis.

Objective:To investigate the clinical curative effect of focused ultrasound on vulval condyloma acuminatum.Methods:108 cases of vulval condyloma acuminatum confirmed by pathology were randomly divided into two groups with the same number in each group:ultrasound group and laser group(controls).54 cases in the ultrasound group were treated with focused ultrasound,other 54 cases underwent laser treatment.The symptoms and local changes of the patients were observed before and after the treatment.The warts were obtained for pathological analysis to evaluate the efficacy of focused ultrasound treatment.Results:1.In the ultrasound group,49 cases recovered after the first treatment,the efficacy rate was 90.7%(49/54),while in the laser group,the rate was 68.5%(37/54).There was significant difference between the two groups(P

Objective:To explore the effect of cholecystokinin on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius.Methods: The effects of gastric distention and intravenous CCK on electricity activity of gastric distention related neurons in the nucleus of tractus solitarius were investigated in urethane anesthetized rats.Results:Intravenous CCK could obviously influence the spontaneous activity of gastric distention related neurons in the nucleus of tractus solitarius.Intravenous CCK could increase the discharge of gastric distention(GD)excited neurons(9/14)and decrease the discharge of GD inhibited neurons(5/14) in NTS.Howerer,the effect of CCK on gastric distention-induced discharge of GD related neurons was always inhibitory.Conclusion:Circulating CCK and gastric distention have both excitatory and inhibitory effects on the electricity activity of gastric distention related neurons in NTS,but the effect of CCK on gastric distention-induced discharge of GD related neurons is inhibitory.The effect of gastric distention on spantenous discharge of neurons in NTS is similar to circulating CCK.

Objective:To discuss the clinical value of pelvic devascularlization in prevention and treatment for gynaecology and obstetrics refractory hemorrhage.Methods:To analyze retrospectively the effect of 15 cases of obstetrics,2 cases of preventing hemorrhage,5 cases of gynaecology refractory hemorrhage,all of these are treated by pelvic devascularlization.Results:There are 2 cases of placenta praevia of central type,(hemostatic scrap interdict uterus artery blood flow,volume of hemorrhage

Objective:To investigate the effect of horticultural therapy on postpartum posttraumatic stress disorder and medical coping method of perinatal depression patients and to provide reference for perinatal depression patients.Methods:A total of 124 perinatal depression patients in Xuchang Maternity and Child Health Hospital from January 2018 to December 2019 were divided into experimental group (62 cases) and control group (62 cases) by random digits table method. The control group received routine nursing, while patients in the experimental group carried out horticultural therapy based on the outine nursing. Before and after intervention, the depression levels were assessed by Postpartum Depression Screening Scale (PDSS), posttraumatic stress was evaluated by Posttraumatic stress CheckList-Civilian version (PCL-C), medical coping method was assessed by Medical Coping Method Questionnaire (MCMQ), respectively.Results:There was no significant difference in the score of PDSS, PCL-C, MCMQ before intervention between the two groups( P>0.05). After intervention, the scores of sleeping/eating disturbance, anxiety/insecurity, emotional lability, cognitive impairment, guilt/shame, contemplating harming oneself, and total PDSS were (8.95 ± 1.37), (9.53 ± 1.57), (10.02 ± 0.79), (7.78 ± 1.43), (9.36 ± 1.81), (7.14 ± 1.56), (61.86 ± 3.78) points in the experimental group, significantly lower than those in the control group (10.11 ± 1.45), (10.96 ± 2.41), (10.81 ± 1.43), (8.61 ± 1.67), (10.35 ± 1.64), (7.84 ± 1.72), (67.93 ± 5.12) points, the differences were statistically significant ( t values were 2.320-7.239, P<0.05). The scores of arousal symptoms, avoidance/numbing, re-experiencing symptoms and total PCL-C were (7.12 ± 0.81), (9.12 ± 1.61), (5.42 ± 1.09), (21.66 ± 2.03) points in the experimental group, significantly lower than in the control group (7.93 ± 1.32), (9.81 ± 2.07), (6.16 ± 1.35), (23.89 ± 2.37) pionts, the differences were statistically significant ( t values were 2.001-5.463, P<0.05). The MCMQ scores in avoidance and yielding were (10.78 ± 2.14), (9.81 ± 2.74) points in the experimental group, significantly lower than in the control group (11.89 ± 2.78), (10.86 ± 2.66) points; their score of facing were (17.39 ± 2.59) points in the experimental group, significantly higher than in the control group (15.95 ± 2.63) points, the difference was statistically significant ( t values were 2.413, 2.971, 2.085, P<0.05). Conclusions:Horticultural therapy can alliviate depression, decrease postpartum posttraumatic stress disorder and promote medical coping method of perinatal depression patients.

Objective:To investigate the effect of Pilates exercise therapy therapy on the bladder function and quality of life of postoperative patients with cervical cancer in young and middle-aged patients.Methods:A total of 124 cases of postoperative patients with cervical cancer in young and middle-aged patients treated in Xuchang Maternity and Child Health Hospital, Henan Province, from January 2018 to December 2019 were divided into experiment group and control group according to the admission time, each group were 62 patients. Participants in the control group received pelvic floor training, while the experiment group carried out Pilates exercise program for three months. The duration of indwelling catheter, residual urine volume and urinary retention rate of two groups were recorded, the bladder function was assessed by Mesure du handicap urinaire (MHU), the quality of life was evaluated by Functional Assessment of Cancer Therapy-Cervix (FACT-Cx).Results:There was no significant difference of the duration of indwelling catheter, residual urine volume and urinary retention rate between two groups ( P>0.05). After 3 months, the MUH scores were (1.91±0.79) points in the experiment group, lower than those in the control group (2.28±1.09) points; the social/family status, emotional status, additional interests scores and total FACT-Cx scores in experiment group were (24.58±1.97), (21.82±1.89), (40.95±2.63), (131.40±5.12) points, higher than those in the control group (23.40±2.79), (20.93±2.34), (39.51±2.77), (126.51±4.73) points, the differences were statistically significant ( t values were 2.052-5.259, P<0.05 or 0.01). Conclusions:Based on the pelvic floor training combine with Pilates exercise can help patients recover bladder function and promote quality of life of cervical cancer in young and middle-aged patients.

Diffuse large B-cell lymphoma (DLBCL) has a high degree of heterogeneity in clinical manifestations,pathological morphology and genetic features.According to its classification by WHO in 2008 WHO,DLBCL is defined as large B-cell lymphoma with diffuse growth and having nuclei similar with or larger than those of normal macrophages.In recent years,the clinical features,morphology,immunohistochemistry,and even gene expression pattern are integrated for classification of DLBCL.It's a new era to stratify DLBLC by gene expression profile.This article summarized research progress in DLBCL classification based on gene expression profile and immunohistochemistry and its effects on prognosis of DLBCL.

Alport syndrome, characterized by hematuria, renal failure, sensorineural deafness, and ocular abnormalities, is an inherited glomerular disease caused by mutations in the COL4A5 (X-linked), or COL4A3 and COL4A4 (autosomal recessive) genes.The ultrastructural changes of Alport syndrome can be observed in the electron microscopic analysis of renal biopsies, which are characterized by irregular thinning/thickening, layering and splitting dense layer of the glomerular basement membrane.In the basement membrane of skin and renal biopsy tissue, type IV collagen α chain immunofluorescence test can be used to diagnose Alport syndrome, screen the carriers and determine the mode of inheritance.The analysis and detection of Alport syndrome gene are not only useful for genetic counseling, but also useful for identification of gene carriers, prenatal diagnosis, and identification of suspected patients who can not be confirmed by clinical and pathological examination results.