1.Control study on adjuvant treatment of brain electromagnetic for patients with neurological disorders
Qiuyuan ZHONG ; Lanxiang ZHONG
Chinese Journal of Primary Medicine and Pharmacy 2011;18(23):3179-3181
Objective To find out the quality of brain function electromagnetic adjuvant therapy for neurosis treatment.Methods 100 patients were randomly divided into two groups,study group(50 cases)was treated for brain function by electromagnetic therapy with the drug treatment,and only drug treatment was used for the control group(50 cases).The psychological symptom checklist(SCL-90)and Pittsburgh Sleep Quality Index Scale(PSQI)were used to assess clinical symptoms and sleep quality of the two groups before and after therapy of 30 days,and the scale results were compared.Results After treatment,somatization,interpersonal sensitivity,anxiety,depression,hostility,phobia,obsessive-compulsive disorder,paranoid and psychotic items score of SCL-90 scale of study group was significantly lower than the scale before treatment(all P <0.05);after treatment somatization and anxiety item scores of SCL-90 scale of study group were significantly lower than the control group(all P <0.05).After treatment PSQI total scale score,sleep latency,sleep continuity,sleep efficiency,the use of sleep medications and sleep disorders of study group were significantly lower than before treatment(all P < 0.01);after treatment PSQI total scale score and all items scores of study group were significantly lower than the control group(all P < 0.05).Conclusion Adjuvant treatment of brain electromagnetic had significant effects of improving sleep quality,relieving anxiety and somatization for neurological patients.
2.Efficacy Observation of A Clotrimazole Combined with Ultrasonic Atomization of Ozone in the Treatment of Candidal Vaginitis
China Pharmacist 2014;(12):2080-2082
Objective:To observe the efficacy of A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis. Methods:Totally 200 cases of candidal vaginitis were divided into the observation group and the control group with 100 cases in each. The control group was given A clotrimazole creams through vaginal administration, qd, while the observation group was treated by ultrasonic atomization of ozone additionally, qd, 15min per time with five times. The clinical efficacy and the recurrence rate after 6 months of the two groups were compared. Before the treatment and in the first and fourth week after the treatment, vaginal secretion bacterial culture was performed and pH value was detected. Results:The cure rate and the total effective rate of the observa-tion group was 88% and 98%, respectively, which was significantly higher than that of the control group (69% and 82%, respective-ly, P<0. 05). After the 6-month follow-up, the recurrence rate was 1. 0% in the observation group (1/98), which was significantly lower than that in the control group [7. 3%(6/82),P<0. 05]. After the treatment, the vaginal pH value in the observation group was reduced notably and the number of lactobacillus was increased significantly(P<0. 05), while those in the control group were without significant changes (P>0. 05). Conclusion:A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis can improve the therapeutic effect.
3.Role of coenzyme Q in xenobiotics-induced mitochondrial damage:its advances
Chinese Journal of Pharmacology and Toxicology 2014;(2):302-308
Coenzyme Q (CoQ),also known as ubiquinone,is a lipid-soluble quinone compound which exists in biological organis ms widely.The numbers of side chain isoprene of different sources of coenzyme Q are different.Coenzyme Q in humans and mammals are called coenzyme Q10 (CoQ10 ,Q10 ), in that the ubiquinone side chain of humans and mammals are mainly composed of 10 isoprene units.In the mitochondrial respiratory chain,it acts as a mobile electron transporter and is a cofactor of uncoup-ling proteins,which is an essential endogenous substance in the process of cell respiration and metabo-lis m.Moreover,CoQ possesses independent antiapoptosis feature,which regulates the mitochondrial permeability transition pore.Mitochondrion is an important organelle,which is the place for energy stor-age and supply,providing the energy for vital movement.There are various kinds of chemical toxicants in the hu man environ ment,and they can enter into the hu man body through drinking,feeding or breath-ing and then affect cell mitochondria to different degrees.Thus,it is important for preventive medicine to investigate intervention or reduction of the biological da mage of exogenous chemicals′effects on mito-chondria.In this paper,we reviewed the research progress of the role of coenzyme Q in xenobiotics in-duced mitochondrial da mage.
4.Drug fever caused by praziquantel:one case report
Chinese Journal of Schistosomiasis Control 2010;22(2):184,191-
One case of schistosomiasis got drug fever after taking praziquantel.
6.Reforming profit-seeking mechanism is the key to public hospital reform
Chinese Journal of Health Policy 2015;(9):1-5
The profit-seeking mechanism which has emerged as an unexpected result of a series of policy choices during the market-oriented healthcare reform is the root cause of almost all problems among the public hospi-tals, and hence the key to the public hospital reform.The mechanism is comprised by three components including the pressure mechanism to create the revenue, the enlargement mechanism to reimburse costs, and the linkage mecha-nism between employee income and hospital surplus.Therefore, a comprehensive policy package should be adopted to undertake these three aspects among which the linkage mechanism is the crucial one.
7.Observations on the Efficacy of Dong’s Extra Point Opposing Needling in Treating Facial Paralysis
Shanghai Journal of Acupuncture and Moxibustion 2016;35(9):1059-1061
Objective To investigate the clinical efficacy of Dong’s extra point opposing needling in treating facial paralysis. Methods Ninety patients with facial paralysis were randomly allocated to treatment and control groups, 45 cases each. In addition to the basic medicine treatment, the treatment group received Dong’s extra point opposing needling and the control group, conventional acupuncture. Facial nerve function was scored using the House-Brackmann (H-B) Facial Nerve Grading System in the two groups of patients before and after treatment. The clinical therapeutic effects were compared between the three groups.Results There were statistically significant post-treatment differences in the H-B scores of various time points between the treatment and control groups (P<0.05). The total efficacy rate and the cure rate were 100.0% and 68.9%, respectively, in the treatment group and 100.0% and 48.9%, respectively, in the control group. There was a statistically significant difference in the cure rate between the two groups (P<0.05). The time needed for cure was (20.15±3.30) days in the treatment group and (28.41±4.92) days in the control group; there was a statistically significant difference between the two groups (P<0.05).Conclusion Dong’s extra point opposing needling plus medication is an effective way to treat facial paralysis.
8.Investigation and Analysis of the Situation of Drugs Used in 165 In-patients With Acute Cerebral Infarction
China Pharmacy 2001;0(07):-
OBJECTIVE:To get an idea of the situation of drugs for in-patients with acute cerebral infarction and to discuss the rationality of use of the drugs METHODS:To investigate and analyse the records of drugs used in 165 patients with first attack of acute cerebral infarction RESULTS:The drugs frequently used included dehydrants,diuretics,anti-platelet-agglutination agents,promoting cerebral circulation agents,brain cell protective drugs and drugs for supporting treatment The drugs commonly used for complications included hypotensors,antiinfectives,drugs for heart diseases,hypoglycemic agents and hypolipoidemic agents But there existed some problems,for example,brain cell protective drugs were used excessively;the change of antiinfectives was too frequent and the drugs used for unduely long course CONCLUSION:The drugs used for in-patients with acute cerebral infarction were in varied kinds,so the rational choice of drugs should be studied in a deepgoing way
9.Comparison of Anti-inflammatory Effects of Granules and Boiling Prescriptions of Xiaoerpingchuan
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(12):-
Objective To compare the anti-inflammatory effects of different dosage forms of Xiaoerpingchuan. Methods Animal models such as mice ear-swelling induced by Dimethylbenzene, rat hindpaw edema elicited by Carrageenan, rat granuloma provoked by cotton-ball and animals were prepared for observing the anti-inflammatory effects of granules and boiling prescriptions of Xiaoerpingchuan. Results Granules prescription inhibited inflammation in all the models, boiling prescription inhibited the inflammatory action only in the model of rat hindpaw edema. Conclusion Both granules and boiling prescriptions of Xiaoerpingchuan had anti-inflammatory effects, and the former was better than the lattern in some experiments.
10.Clinical significance of testing anti-myeloperoxidase antibody in patients with glomerular diseases
Journal of Chongqing Medical University 1986;0(02):-
0.05).The levels of serum anti-MPO antibody in patients with lupus nephritis(LN)and purpuric glomerulonephritis had significantly increased(P