OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P

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With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

Objective To study the current application and influencing factor of emergency medical service in patients with acute heart failure in our hospital.Methods 254 patients with acute heart failure who visited our hospital from January 2008 to December 2010 were selected.Data were collected by questionnaire and medical records in one week after admission to the hospital.The current application and influencing factors of emergency medical service in patients were analyzed.Results Of all the patients with acute heart failme,only 89(35％)arrived at the hospital by emergency medical service,but the rest 165(65％)relied on self-transport.Multivariate logistic analysis showed that age,sex,education level,unbearable symptoms and attribution of symptoms to cardiac origin were independent predictors of the use of emergency medical service.The effective treatment rate was higher,and the pre-hospital time was shorter in patients who used emergency medical service than those relied on self-transport.Conclusions The use rate of emergency medical service in patients with acute heart failure is low,and age,sex,education level,the characters of symptoms and cognitive factors of patients influence the use of emergency medical service in patients with acute heart failure.

Objective To investigate the application effect of intensified nursing intervention in severe pneumonia complicated with ventilator-associated pneumonia. Methods 78 senile patients admitted to hospital with severe pneumonia complicated with ventilator-associated pneumonia from November 2009 to November 2010 were chosen as the research object.They were randomly divided into the observation group and the control group with 39 cases in each group.The control group was treated with conventional and comprehensive methods of care.The observation group was taken intensified intervention on the basis of the control group.The utility time of ventilator after complication with ventilator-associated pneumonia,hospital stay time,complications and mortality rate for the two groups were compared. Results The utility time of ventilator,hospital stay time,complications and mortality rate for the two groups were compared.The observation group had a clear advantage over the control group,there was significant difference. Conclusions Nursing intervention can be targeted to enhance the improvement of the overall respiratory status in severe pneumonia complicated with ventilator-associated pneumonia.It contributes to inflammation control,and can reduce utility time of ventilator and length of hospital stay,reduce the corresponding incidence of complications and mortality rate,it is worthy of clinical application.

Objective To investigate the curative effect of western combined with traditional Chinese medicine in treatment of acute lumbar disc herniation.Methods 200 patients with lumbar disc herniation were randomly divided into western combined with traditional Chinese therapy group(group A) and western medicine group(group B) ,each group 100 cases.B group was conducted with the general anti - inflammatory, dehydration, nerve pain and nutritional therapy,and A group was given the traditional Chinese medicine treatment on the base of B group.After 3 weeks treatment, the curative effect, VAS score and hospital stay were observed.Results A total effective rate 90.0% in group A was higher than B group 73.0% ( x2 = 3.987 ,P < 0.05); The scores of VAS after treatment 4 weeks[(1.1 ±1.23、0.9 ±0.6)/point]were lower than before treatment[(8.6 ± 1.43,8.8 ± 1.382)/point]in two groups(t =2.301,2.335,all P<0.05) ;The scores of VAS after treatment 3d and 1 week in group A[(5.5 ±0.92) point,(2.7±1.14) point] were lower than group B[(8.2 ±0.59) point,(5.3 ±0.91) point] (t =2.405,2.435,all P<0.05);The hospital days(20.1 ±3.5)d in group A was significantly lower than group B(27.6 ±4.3)d( t = 2.314,P <0.05).Conclusion Western combined with traditional Chinese medicine had better clinical efficacy in teatrent of patients with acute lumbar disc hemiation.

Objective:To investigate the factors affecting the pre-analysis quality in clinical chemistry tests,and to recognize the importance of quality control and management before analysis, also to establish the synthetic management system of pre-analysis quality control.Methods:The database of management system was established by VFP6.0,and the common problems were statistically analysed in clinical chemistry tests from June of 1999 to May of 2002, and the qualified rate of samples was made the quality control index of clinical department.Results:The error occurrence rate of clinical chemistry tests was 1.53‰-2.04‰.The error constitution ratio of pre-analysis, mid-analysis and post-analysis were 64.25%,23.83% and 11.92%,respectively.The first four factors affecting the pre-analysis quality were unstandard sampling,delayed sample delivering,unqualified sample,and unstandard preparation of patients.Conclusion:The pre-analysis quality control of clinical chemistry tests is the essential stage in emphasizing quality control and the prerequisite of ensuring the precise and timely results.It needs the effort and participation of laboratory staffs,clinical medical workers and patients.

Pheochromocytoma is the catecholamine-secreting tumor arising from the adrenal medulla and extra-adrenal chromaffin cells and the important cause of endocrine hypertension, which leads to serious complications of the heart, brain and renal vascular events. The prevalence of phochromocytoma accounts for approximately 1.9% in the population with hypertension. The detection, diagnosis and treatment of pheochro-mocytoma at early stage are of uppermost importance. More efforts should be made to study the pathogenesis and management of pheochromocytoma.

Objective: To investigate the incidence of obesity of urban and rural children in Chongqing areas and to explore the relationship between weight and blood pressure.Methods: Screening was performed in 37785 children aged 7 to 17 years from September 2003 to September 2004 in Chongqing areas.Age,gender,weight,height and blood pressure were ascertained.Results:(1) Overweight and obesity prevalence rates in urban children were 13.16% and 3.73%,respectively,and in rural ones,5.26% and 0.90%,respectively.(2) The prevalence rate of overweight and obesity in male children is 13.16%,and 8.39% in female ones.(3) The prevalence rates of increased systolic and diastolic blood pressure in overweight and obesity children were significantly higher than in normal weight ones.Conclusion: The prevalence rates of overweight and obesity in urban children in Chongqing areas are higher than in rural ones.The prevalence rates of overweight and obesity in male children are higher than in female ones,and the blood pressure increased progressively as the BMI increased.The behavior intervention should be strengthened in overweight and obesity children.

Objectives:The study was designed to observe the effects of L-arginine(Arg) supplemented enteral nutrition on cellular immunological function in rats with severe head injury.Method:The severe head injury of rats was produced by gas percussion.Thirty rats were divided randomly into 3 groups(n=10): normal control group,enteral nutrition(EN)group and EN+Arg group.Rats in groups EN and EN+Arg were supplemented with tyrosine at the does of 0.8g?kg~(-1)?d~(–1)and Arg at the dose of 0.8g?kg~(-1)?d~(–1)for 7days,respectively.Blood samples were collected after 7 days.PMN phagocytosis rate was observed by phagocytosis Candida albicans count.CD4~(+)cells and CD8~(+) cells were analyzed by SABC.The concentration of serum IL-2 level was measured by radioimmunoassay.Results:Decreased cellular immunolgical function was found on 7~(th) day after severe head injury.However,CD4~(+),CD4~(+)/CD8~(+),IL-2 level and PMN phagocytosis rate in EN +Arg group were better than that in EN group.There was significant difference in each immunological index(P