With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P

This paper briefly describes China-produced Resina Draconis in respect to the sources of original plant,refining process, chemical compositions,quality analysis and present status of its application in China.

This paper briefly describes the manufacture of active vitamin E capsules utilizing high bioavailability technique. Experimental results demonstrate that the product shows good dispersivity,stable quality and no side effects. The bioavailability of the new product is more than 3 times that of commonly used vitamin E capsules, so it has satisfactory curative effect and salty in use.

Objective To explore the clinical efficacy of laparoscope in the treatment of nulliparous women with tremendous ovarian cysts .Methods 46 cases of nulliparous women were divided into the two groups according to the operation method .23 cases in the laparoscopic surgery group received laparoscopic pneumoperitoneum needle treatment.23 cases in the open group were given the traditional open surgery .Before operation,the umbilical region and vagina of these patients were cleaned ,and antibiotics was given to the two groups .The operative time,postopera-tive bleeding,exhaust time,hospitalization time,the number of cases of postoperative pain ,menstrual conditions and recovery time of daily living activities were compared .Results The operative time of the laparotomy group was (68.3 ±12.3)min,which was significantly longer than (59.6 ±11.5)min of the laparoscopic surgery (t=4.26,P<0.05).The number of pain after surgery in the laparoscopic surgery group and laparotomy group were 11 cases,21 cases. The incidence rate of postoperative pain in the laparoscopic surgery group was 47.8%,which was significantly lower than 91.3% in the laparotomy group (χ2 =10.3,P<0.05).Conclusion Laparoscopic treatment for nulliparous women with ovarian cysts showed shorter operative time ,less blood loss ,faster exhaust time ,shorter hospital stay ,less pain and faster recovery .This surgery scheme deserved to be introduced and further studied .

Objective: To compare the clinical efficacy of abdomen acupuncture with body acupuncture for treating lumbar intervertebral disc protrusion. Methods: One hundred and thirty three patients were randomly allocated to a treatment group of 67 cases and a control group of 66 cases. The patients in the treatment group received abdomen acupuncture and those in the control group, body acupuncture. The improvements in the symptoms were compared after treatment. Results: The efficacy rate was 95.5% in the treatment group and 86.4% in the control group; there was a statistically significant difference between the two groups (PO.05). The cure rate after one course of treatment was significantly higher in the treatment group than in the control group (PO.05). Conclusion: Abdomen acupuncture has a good effect on lumbar intervertebral disc protrusion with a short course of treatment.

Pediatric allergy,immunology and rheumatology (PAIR) discipline is one of the important branch of pediatrics in China.It covers the pediatric allergic diseases,immunodeficiency diseases,rheumatic diseases and the clinical and research aspect which is associated with infection and immunity including inflammation,and inflammatory diseases,et al.Though it is an interdisciplinary discipline which has a long history and being paid great attention and construction rapidly in early a decade,but it is still in the early stages of development in China.How to promote its reasonable,scientific,and further development quickly to adapt to the high-speed social medical service growth of demand in this field is an important task which we have to face to.This article reviews the discipline development history,present situation and futue trend.

Multiple myeloma (MM) is a hematological malignancy. Osteolytic lesion is the commonest complication in patients with MM. Skeletal-related events severely affect the survival quantity and prognosis. Current therapeutic approach for the treatment of myeloma bone disease (MBD) is based on the use of bisphosphonates. AS the recent advance in the pathogenesis and therapeutics of MBD,more factors related to this disease are found. In this article important factors related to the pathogenes of MBD and the cytokine targeted therapies are reviewed.

After the application of project-based teaching in medical information retrieval course for grade two un-dergraduates of Guangzhou Medical University Vocational Health Technology School was described , the examination records were compared between project-based teaching group and traditional teaching group with the problems sum-marized and measures proposed for their solution .

Objective:To explore the relationship among carotid intima‐media thickness (IMT) ,plaque score ,plasma level of C reactive protein (CRP) and coronary artery lesion in patients with coronary heart disease (CHD) .Meth‐ods:A total of 83 CHD patients were enrolled as CHD group and 37 patients without CHD were enrolled as non‐CHD group .CHD patients received coronary angiography .According to number of diseased coronary vessels ,CHD patients were divided into single vessel coronary disease group (n=28 ,single vessel group ) ,double‐vessel coronary disease group (n=31 ,double‐vessel group) and triple‐vessel coronary disease group (n= 24 ,triple‐vessel group) . Plasma CRP level and carotid IMT were measured ,and carotid atherosclerotic plaques were classified in all groups . Results :Compared with non‐CHD group ,there were significant rise in CRP level [ (0.89 ± 0.54) mg/L vs . (3.50 ± 3.42) mg/L] and IMT [ (0.65 ± 0.27) mm vs . (1.04 ± 0.31) mm] in CHD group (P<0.05 or <0.01);Com‐pared with single‐vessel group and double‐vessel group ,the CRP level of triple‐vessel group [ (1.44 ± 1.03) mg/L , (3.71 ± 3.52) mg/L vs .5.82 ± 3.98) mg/L] significantly rose ;the percentage of carotid plaque class 3 of triple‐ves‐sel group (0% 、0% vs .25% ) significantly rose (P<0.01 all) .Conclusion:C reactive protein level and carotid intima‐media thickness significantly rise in patients with coronary heart disease ,and there are significant rise in C reactive protein level and percentage of carotid atherosclerotic plaque class 3 in patients with multi‐vessel coronary disease .