OBJECTIVE:To facilitate the construction of Chinese pharmaceutical profession associations. METHODS: We analyzed the current situation and problems existing in Chinese pharmaceutical profession association as well as the developmental experience of foreign pharmaceutical associations then put forward suggestions for the development of pharmaceutical profession associations in China. RESULTS & CONCLUSIONS: The sound development of pharmaceutical profession associations calls for the cooperated efforts of government, profession association and pharmaceutical enterprises, meanwhile its function as bridge and tie between pharmaceutical enterprises and government should be brought into full play.

Objective To investigate the application effect of indwelling needle puncture in the axillary vein of newborn infants.Methods From September 2015 to February 2016,the venous indwelling needle puncture was given for neonatal transfusion 180 cases,including 90 cases of the axillary vein indwelling needle infusion in the experimental group,and 90 cases of puncture of extremity vein infusion in the control group.The application effect of the 2 groups was compared.Results There were significant differences in terms of indwelling needle shedding,phlebitis,drug extravasation,lien time between the experimental group and the control group (P ＜ 0.05) Conclusions During neonatal indwelling needle puncture infusion process,the axillary vein indwelling needle infusion can prevent the indwelling needle shedding,decrease the incidence of phlebitis and reduce the incidence of drug extravasation,and can prolong the indwelling time.Puncture in the simple operation easy,is easy to learn and no need for special facilities and equipment,only conventional intravenous infusion required material,plus 24g indwelling needle,aseptic transparent dressing,paper tape,economical and practical,suitable for application in neonatal ward.

Objective To discuss the safety and feasibility of radiofrequency ablation (RFA)combined with transcatheter arterial chemoembolization(TACE)for patients with primary liver carcer(PLC).Methods 64 cases with PLC were selected and randomly divided into two groups,32 cases in each group.The observation group accepted TACE combined with RFA therapy,while the control group only received TACE treatment.Term efficacy (after 1 year)and 1,2,3 -year survival rate were compared in the two groups.The changes of liver function parameters including aspartate aminotransferase (AST),alanine aminotransferase (ALT) and γ-aminoacyl transferase (γ-GT)of the two groups were analyzed and compared.Results After 1 year of treatment,the remission rate was 71.9% (23 /32)in the observation group,which in the control group was 43.8% (14 /32),the difference was statis-tically significant (χ2 =5.189,P <0.05).The 1,2,3 -year cumulative survival rates were 65.6% (21 /32),65.6%(21 /32)and 62.5% (20 /32)in the observation group,which in the control group were 37.5% (12 /32),28.1%(9 /32)and 21.9% (7 /32),the differences were statistically significant (χ2 =5.067,9.035,10.83,all P <0.05). After 2 months of treatment,AST,ALT and γ-GT levels in the observation group were significantly higher than those in the control group(t =4.218,2.449,8.647,all P <0.05).Conclusion TACE combined with RFA therapy can significantly improve the clinical symptoms of patients with PLC,which can improve liver function in patients and help prolong the survival time.

Toll-like receptor,TLR (TLR) can sense invading pathogens,the acute inflammatory response in the body,chronic airway inflammation and pathophysiology of allergic diseases and play an important role in the immune defense response.Among them,TLR2,TLR4 most prominent role and become a hot research topic.This paper summarizes the importance of TLR2,TLR4 in the pathogenesis of respiratory tract infections,and pointed out by interfering with TLR2,TLR4 signal transduction pathway or reduced TLR2,TLR4g role may help to weaken the disease or improve the prognosis,which provides a new way of thinking and clues for the treatment of clinical common diseases.

Objective To investigate the influence of thymosin injection combined with chemotherapy on the immune function and quality of life in patients with ovarian cancer. Methods A total of 206 patients with ovarian cancer were chosen and were divided into the control group (n = 103) and the observation group (n = 103) according to the random number table. The control group received chemotherapy. Based on the treatment of control group, the observation group was additionally treated with thymosin injection, the immune function and quality of life were analyzed and compared between two groups. Results The rates of effectivity and disease control were higher in the observation group than those in the control group [44.66 % (46/103) vs 30.10 % (31/103), 86.41 % (89/103) vs 66.99 % (69/103)], the differences were statistically significant (χ2 =3.942, 4.138, P = 0.022, 0.015), and number of cases of adverse reactions were lower in observation group than those in the control group (22 cases vs 35 cases, χ2= 3.601, P = 0.026), and the improvement rate of quality of life of patients were higher in the observation group than that in the control group [60.19 % (62/103) vs 40.78 % (42/103), χ2 = 3.974, P = 0.021]. After treatment, the expression levels of IgA, IgG, IgM and CD3, CD4, CD4/CD8, NK cells were significantly higher in the observation group than those in the control group, the difference was statistically significant (all P < 0.05). Conclusion Thymosin injection combined with chemotherapy is helpful to improve the immune function and the quality of life in patients with ovarian cancer, it is worthy of wider promotion and application.

ObjectiveTo evaluate the correlation of peripheral IL-10/IL-17 expression and pulmonary function in children withMycoplasma pneumoniae pneumonia (MPP).MethodsChildren with MPP (n=66) were recruited and divided into MPP gasp groups (n=31) and MPP no-gasp group (n=35) based on whether pulmonary wheezing sound exists. Another 30 healthy children were recruited as control group. ELISA was used to detect the level of interleukin - 6 (IL - 6) and transforming growth factor-β (TGF-β). The peak expiratory lfow (PEF), forced expiratory volume in 1 s (FEV1), forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) and lung capacity maximum expiratory lfow (V75, V50, V25)were detected by pulmonary function instrument.ResultsThe serum IL-10 level of MPP gasp groups, MPP no-gasp group and control group were(8.1±1.8) ng/L,(13.3±2.0)ng/L and(18.4±1.7)ng/L, respectively; the serum IL-17 level were(23.8±2.3)ng/L,(16.2±1.5)ng/L and (11.4±1.0)ng/L, respectively; which showed signiifcant differences between each group(P<0.05). The PEF, FEV1 and FEV1/FVC of MPP gasp groups were(71.4±5.7)%,(71.8±6.3)% and 72.5±9.6; and those of MPP no-gasp group were(95.3±7.8)%, (96.2±10.5)% and 85.3±4.5; which showed signiifcant differences between the two groups(P<0.05). The V75, V50 and V25 were(74.7±5.0)%,(45.2±10.3)% and(38.3±8.7)%, and those of MPP no-gasp group were(85.6±4.2)%,(75.9±9.5)% and (66.1±12.5)%. Pearson correlation analysis showed that PEF, FEV1, V75, V50 and V25 had positive correlation(P?0.05)with the level of IL-10 and f IL-17 (bothP?0.05).ConclusionMPP children have IL-10/IL-17 imbalance, and the expression of IL-10/IL-17 was correlated with pulmonary function changes.

Objective To discuss the relationship of miR-21 expression and IL-12 level in patients with chronic obstructive pulmonary disease.Methods Chosed 80 patients with suspected chronic obstructive pulmonary disease(COPD)and 50 cases as control group.Real-time RT-PCR was performed to determine the expression 1 evels of miR-2 1 of peripheral blood mono-nuclear cells of three groups.To detect IL-1 2 level by ELISA method.Results There were no statistical difference among GLU,TC and TG level among stable phage,acute phage of COPD and control group(F=0.341~1.542,P>0.05).Howev-er miR-21 expression and IL-12 level had statistical difference (F=8.951~15.017,P<0.05).The expression 1evels of miR-2 1 of peripheral blood mononuclear cells of acute phage group were apparently higher than stable phage,health group(P<0.05).The concentration of IL-12 in serum of acute COPD group was higher than other two groups(P<0.05),compared with stable COPD group and health group.IL-12 level was positiveiy related to miR-21 expression (r=-0.381~0.496). Conclusion miR-2lmay be involved in the regulation of IL-12 expression.miR-21expression may be closely related to the pathogenesis of COPD.

Objective To investigate the application effect of the puncture method of indwelling needle by single hand in clinical attendance of pediatrics. Methods From March 2015 to September 2015,578 patients in our pediatrics were randomly and equally divided into two groups. The experiment group were treated with the puncture method of indwelling needle by single hand and the control group received traditional puncturing method. Results There were statistical significances in the success rate of first puncture,degree of comfort,sense of pain,dropping of the indwelling needle,phlebitis,exosmosis of drugs and indwelling time of patients between the two groups(P< 0.05). Conclusion In the process of using indwelling needle in pediatrics,the application of the puncture method of indwelling needle by single hand could improve the success rate of first puncture of venous retention needle,enhance the comfort degree of neonates,relieve the sense of pain,reduce the dropping of the indwelling needle,incidence of phlebitis and exosmosis of drugs,and prolong the indwelling time. The operation of this puncture is simple and easy to do and to learn,without any special equipment. In the venous puncture,the only necessities are 24G retention needle,3M indwelling needle and adhesive tape. Obviously,it is economical and practical,and is suitable for application in clinic.

Objective To investigate the clinical efficacy of auricular plaster therapy plus scalp acupuncture in treating post-stroke depression.Methods One hundred and twenty-five patients with post-stroke depression were randomly allocated to group A of 42 cases, group B of 42 cases and group C of 41 cases. Group A received scalp acupuncture alone; group B, auricular plaster therapy alone; group C, auricular plaster therapy plus scalp acupuncture. The Hamilton Depression Scale (HAMD) score was recorded in the three groups before and after treatment. The clinical therapeutic effects were compared between the three groups. Results There was a statistically significant pre-/post-treatment difference in the HAMD score in the three groups after two months of treatment (P<0.01). There was a statistically significant difference in the HAMD score between group C and group A or B after one and two months of treatment (P<0.05). The total effective rate and marked efficacy rate were respectively 95.0% and 33.3% in group A, versus 88.1% and 35.7% in group B, and 92.7% and 56.1% in group C, and the marked efficacy rate in group C were significantly different from that in group A and group B (P<0.05). There is not a statistically significant difference in the total effective rate among the three groups (P>0.05).Conclusion Auricular plaster therapy plus scalp acupuncture is an effective way to treat post-stroke depression.

Objective To observe the clinical effect of minimally invasive with AO joint anatomic locking plate under arthroscope and traditional internal fixation on treatment of severe comminuted fracture of tibial plateau.Methods Thirty-six cases of patients with severe comminuted fracture of tibial plateau were treated in Zhongshan Hospital Affiliated to Dalian University from June 2013 to June 2015 were selected.All patients received minimally invasive treatment with AO joint anatomic locking plate under arthroscope.At the same time,35 cases of patients under traditional fixation were selected as the control group.General surgery information including operation time,intraoperative blood loss,length of incision,limb shortening,knee flexion degree and knee HSS score of patients in both two groups were observed.Results The operation time,intraoperative blood loss,length of incision of the research group were (95.1 ± 20.4) min,(385.4 ± 40.7) ml and (1.9±0.7) cm respectively,(77.6±14.3) min,(456.7±45.1) ml and (4.0±1.2) cm for the control group,the differences were significant (t =4.175,6.997,9.038;P ＜ 0.05).The limb shortening,knee flexion degree of the research group were (0.9±0.7) mm and (112.1 ± 14.8) ° respectively,(2.5± 1.8) mm and (90.1± 10.6) ° for the control group,the differences were significant (t =4.962,7.183;P＜ 0.05).After treatment,the knee joint HSS score of the research groups was (84.9±9.7),(69.1±7.3) for the control group,the difference was significant(t =7.738,P＜0.05).Conclusion The clinical effect of minimally invasive treatment of severe comminuted fracture of tibial plateau with AO joint anatomic locking plate under arthroscope is significant,with smaller invasion,better postoperative recovery than traditional fixation,and can promote the recovery of neural function.