OBJECTIVE:To facilitate the construction of Chinese pharmaceutical profession associations. METHODS: We analyzed the current situation and problems existing in Chinese pharmaceutical profession association as well as the developmental experience of foreign pharmaceutical associations then put forward suggestions for the development of pharmaceutical profession associations in China. RESULTS & CONCLUSIONS: The sound development of pharmaceutical profession associations calls for the cooperated efforts of government, profession association and pharmaceutical enterprises, meanwhile its function as bridge and tie between pharmaceutical enterprises and government should be brought into full play.

Humans ; Pulpitis ; diagnosis

Arthralgia ; etiology ; Arthroplasty, Replacement, Knee ; adverse effects ; Humans ; Knee Joint ; surgery ; Pain, Postoperative ; etiology

Chronic Disease ; Cone-Beam Computed Tomography ; Humans ; Periapical Abscess ; pathology ; Periapical Granuloma ; pathology ; Periapical Periodontitis ; diagnostic imaging ; pathology ; Problem Solving ; Prognosis ; Radicular Cyst ; diagnostic imaging ; pathology

Excitatory Amino Acids ; secretion ; Humans ; Neurotransmitter Agents ; secretion ; Pain, Postoperative ; etiology ; metabolism ; prevention & control

AIM: To verify the protection of astragalus polysaecharide (APS) on H2O2 - stressed skin fibro-blasts. METHODS: A model of acute H2O2 stress in primary skin fibroblast was used at concentration of 0.5 mmol/L by 30 rain incubation. Dose responses of APS on cell survival was measured by MTI, cell death was evaluated by DAPI, and effect of APS on mitochondria, mitochondrial membrane potential and lysesome stabilization were measured by confocal microscopy. RESULTS: APS improved cell survival in a dose -dependent manner, starting at 0. 5 mg/L and with a maximum at 1 mg/L. Moreover, APS inhibited mitochondrial membrane potential collapse, protected mitechondrial morphology and stablized lysosomal membrane. CONCLUSION: The results suggest the existence, at the mitochondria-lysosome level, of a new pathway of apoptotic regulation by APS. This might constitute a new therapeutic target where oxidative stress and lysesomal impairment are involved.

BACKGROUND: For spasticity and flaccidity after stroke are different between each other qualitatively,the treatments of them with acupuncture are various.OBJECTIVE: To probe into the effective therapeutic methods for limb spasticity after stroke.DESIGN: A randomized controlled observation based on patients.SETTING: Department of acupuncture and massage in a college of traditional Chinese medicine.PARTICIPANTS: All of the cases were originated from 57 in-patients collected from the ward of Department of Acupuncture and Moxibustion of First Affiliated Hospital of Hunan College of Traditional Chinese Medicine from January 2002 to December 2003.METHODS: According to the admission sequence of patients,two groups were divided by the random number table. Muscle-region acupuncture was formed on the basis of joint needling( guan ci),relaxing needling( hui ci)and fire needling(fanzhen jie ci) and was used to treat 24 cases of spasticity of stroke. In addition,the control of 24 cases was designed treated by the points only on yangming meridian. The comparative observation on therapeutic effects was carried on with Ashworth and SIAS,the relevant evaluation methods on spasticity in modern rehabilitation medicine,and with isodynamic time-measuring method as well.MAIN OUTCOME MEASURES: ① SIAS integrals; ② Ashworth grades of spasticity; ③ Isodynamic time-measuring method.RESULTS: SIAS integrals before and after treatment were 6.98 ± 3.52,12.59 ± 3.36 in muscle region group,and 7. 12 ± 3.38,8.75 ± 3.42 in yangming group,indicating significant difference( P ＜ 0. 01). The differences were also significant in Ashworth analysis and quantitative evaluation with isodynamic time-measuring method on spasticity in two groups ( P＜0.05 or P ＜ 0.01).CONCLUSION: Muscle region needling is a kind of method with definite therapeutic effect on spasticity after stroke in acupuncture and moxibustion.

MicroRNA (miRNA),an abundant class of small non-coding RNA,are abundant in the central nervous system where they play important roles in the neuronal development and plasticity.Moreover,the relationship between miRNA dysfunction and neurological diseases become more and more apparent.Recent studies show that the misregulated expression of miRNA out of control is closely related to the development of glioma.In this review we discussed the progress on the study of miRNA in Glioma.

10.3969/j.issn.2095-4344.2013.24.023

Objective To investigate the clinical efficacy of amlodipine combined with atorvastatin in treatment of hypertensive patients complicated with coronary heart disease.Methods 80 hypertension patients complicated with coronary heart disease were randomly divided into the observation group 40 cases,control group 40 cases.Control group was given amlodipine treatment,the observation group was given amlodipine and atorvastatin calcium therapy.The clinical efficacy of two groups were compared.Results The hypertension excellent and good rate of the observation group was 95.0％,77.5％ in the control group.The excellent and good rate of coronary heart disease in the observation group was 87.5％,75.0％ in control group.The excellent and good rate of hypertension and coronary heart disease between two groups had statistically significant differences(x2 =23.12,18.98,all P ＜ 0.05).The incidence rate of adverse reaction in observation group was 10％,control group 10％,which showed no significant difference between the two groups (P ＞ 0.05).Conclusion Amlodipine combined with atorvastatin calcium has the exact clinical efficacy in the treatment of hypertension and coronary heart disease,it can improve the patients' quality of life and worthy of clinical application.