Objective To observe the clinical efficacy of acupuncture plus cognitive function training in treating Parkinson's disease dementia.Methods Sixty Parkinson's disease dementia patients were randomly allocated to a treatment group and a control group, 30 cases each. The treatment group was intervened by acupuncture plus cognitive function training, and the control group by conventional drug treatment. The Mini-Mental Status Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were recorded in the two groups before and after the treatment. The therapeutic effects were compared between the two groups.Results The MMSE score and MoCA score were significantly changed after treatment in the two groups (P<0.05). There were significant post-treatment differences in the MMSE score and MoCA score between the treatment group and control group (P<0.05). The total effective rate was 90.0% in the treatment group versus 70.0% in the control group, and the difference was statistically significant between the two groups (P<0.05).Conclusions Acupuncture plus cognitive function training can effectively improve the symptoms of Parkinson's disease dementia.

In view of such outcomes of the performance pay practice at primary healthcare institutions as decline of motivation of medical workers,the county explored the mechanism of graded performance appraisal and allocation,against the macro background of ceiling setting for the total of performance pay andbalance subsidy and total amount controlfiscal policy.The following measures are taken,namely a dual linkage to relate the performance appraisal outcome of a township hospital with both allocation of fiscal subsidy and setting of the merit-based performance pay standard per person;higher ratio of merit-based performance pay;floating of the performance pay level per person for the institution in question;separation of the performance pay of the chief leader from others;and subsidies for remote mountainous areas.It is proposed by the author to build a routine increase mechanism for both the total of performance pay and fiscal subsidies,to combine specific subsidy with pay for services,and to join funding compensation with service performance.These measures are expected to create a new mechanism for performance pay allocation,featuring more pay for more work and more pay for better performance.

Along with the extensive understanding of differentiated thyroid cancer (DTC), its distinct molecular genotype and signaling pathway was revealed, which improved the development of molecular-targeted therapy. Regarding radioactive iodine-refractory DTC, multiple multikinase inhibitors including sorafenib and lenvatinib, which target vascular endothelial growth factor (VEGF) pathway, were proved to be effective. Moreover, selective inhibitors and redifferentiation agents were shown to be promising. In the future, individual genetic testing would provide more speciifc information in directing individualized molecular-targeted therapy.

[Summary] Pancreatic neuroendocrine tumors( P-NETs) is the most important cause of mortality for patients with multiple endocrine neoplasia type 1 ( MEN1 ) . Improved outcome depends on early diagnosis and optimal management. In this perspective, we are discussing the updated studies and challenges regarding as biochemical screening, tumor localization, prognosis prediction, surgery and therapy of advanced diseases.

Objective To explore the effect of azithromycin sequential therapy on inflammatory cytokines and humoral immune function in the treatment of children with mycoplasma pneumonia.Methods 342 children with mycoplasma pneumonia were divided into control group(168 cases)treated with erythromycin sequential therapy and observation group (174 cases)treated with azithromycin sequential therapy based on the random number table.The changes of inflammatory cytokines and humoral immune function were recorded and compared.Results The levels of interleukin 4(IL -4),interleukin 6(IL -6),C -reactive protein(CRP)and tumor necrosis factor -α(TNF -α) had no significant differences between the two groups before accepting different treatments (P >0.05).The decreased levels of IL -4,IL -6,CRP and TNF -αof the observation group after treatment were greater than the control group (t =10.913,11.047,9.919,53.207,all P <0.01).The levels of immunoglobulin M(IgM),immunoglobulin G(IgG) and immunoglobulin A(IgA)had no significant differences between the two groups before accepting different treat-ments (P >0.05).After treatment,the decrease of IgM and IgG between the two groups had significant differences (t =3.178,3.034,all P <0.01 ).Conclusion Azithromycin sequential therapy for the treatment of children with mycoplasma pneumonia has better clinical efficacy than erythromycin sequential therapy,which can improve inflamma-tory cytokines index and regulate humoral immune function.It has considerable value in the clinical application.

Objective:To discuss the curative effect of Saccharomyces boulardii Sachets in the treatment of children with hand-foot-mouth disease (HFMD) and explore the influence on serum procalcitonin (PCT) and interleukin-6 and 12 (IL-6 and 12) levels. Methods:Totally 88 cases of children with HFMD were selected and divided into the observation group and the control group at ran-dom. The children in the two groups were given routine medical treatment, such as anti-virus, defervesce, nutrition support and etc. The children in the observation group were additionally given 0. 25g Saccharomyces boulardii Sachets, once a day with warm boiled wa-ter. The changes in serum PCT, IL-6 and 12 levels of the children before and 72 hours after the medical treatment were observed, and the clinical curative effect and adverse reactions were compared as well. Results: After the 72-hour medical treatment, serum PCT, IL-6 and 12 levels of the children in the two groups were declined in different degrees (P<0. 05 or P<0. 01), and the declining rate in the observation group was much higher than that in the control group (P<0. 05). The total clinical efficiency of the observation group was also much higher than that of the control group. The adverse reactions appeared respectively in the control group and the ob-servation group during the medical treatment show no significant difference(P>0. 05). Conclusion:Saccharomyces boulardii Sachets used as adjunctive therapy show favorable curative effect and safety in the treatment of children with HFMD, which can reduce serum PCT, IL-6 and 12 levels, and inhibit the immune inflammatory reaction process in children.

Objective:To observe the clinical effects of acupuncture at Yaotongdian (EX-UE 7) plus the oblique Ban-pulling manipulation for acute lumbar sprain. Methods:A total of 180 patients were divided into an observation group and a control group by drawing lots. The 98 cases in the observation group were treated by puncturing Yaotongdian (EX-UE 7) plus the oblique Ban-pulling manipulation. The 82 cases in the control group were only treated by the oblique Ban-pulling manipulation. After the two groups were treated continuously for three sessions, the therapeutic effects were observed. Results:In the observation group, 96 cases were cured and 2 cases were improved; the curative rate was 98.0% and the total effective rate was 100%. In the control group, 76 cases were cured, 4 cases were improved and 2 cases failed; the curative rate was 92.7% and the total effective rate was 97.6%. In comparison of the curative rate and total effective rate, the differences were not statistically significant (P>0.05). But, the curative rate after the first treatment was higher in the observation group than that in the control group, with a significant difference between the two groups (P<0.05). Conclusion:The therapeutic effects were similar by acupuncture at Yaotongdian (EX-UE 7) plus oblique Ban-pulling manipulation and by single oblique Ban-pulling manipulation for acute lumbar sprain. But, it took effect quickly by puncturing Yaotongdian (EX-UE 7) plus the oblique Ban-pulling manipulation.

Homing and engraftment of transplanted hematopoietic stem cells (HSCs) can directly influence the effect of the transplantation.Exploration on its spatial distribution,location and interaction with the bone marrow (BM) microenvironment is great significance.Since the BM cavity is closed and surrounded by thick compact bone,it makes a colossal challenge to track the transplanted HSCs in vivo directly.Recently,researchers used different innovative methods to observe the spatial distribution and interaction with the BM microenvironment of the transplanted HSCs.The present review summarized the progress in the HSCs transplantation.

Objective To understand the health status of the staff at a vocational technology college and analysis the cause of health problems.Methods The data were analyzed and had been statistical processing according to the physical examination reports of a total of 707 Changzhou hygiene teaching staff from 2011 to 2013.Results The top ten diseases and total prevalence were as follows:Abnormal electrocardiogram 48.44％ (295/609),dyslipidemia 39.97％ (247/618),the male prostate hyperplasia 38.82％ (73/188),the female mammae lobule hyperplasia and breast lump 29.05％ (147/506),hypertension 27.44％ (152/554),the female uterine myoma 21.94％ (111/506),fatty liver 21.77％ (133/611),hepaticcysts 20.62％ (126/611),gallbladder polyps and cholecystitis18.66％ (114/611),elevated blood sugar 9.53％ (59/619).Dyslipidemia and abnormal of electrocardiogram were on the rise overall during the three years.Dyslipidemia was releated to sex and age,the number that plasma lipid of women aged from 55 to 64 reach appropriate level was lowest.Conclusions The faculty of vocational colleges have higher incidence of chronic diseases.Women group aged from 55 to 64 have highest incidence of dyslipidemia;more active,targeted measures need be taken.

Neuroblastoma (NB)is a common malignant solid tumor in childhood,which has various clinical manifestations.It is difficult to diagnose and to prone to early metastasis.It is one of the main diseases causing death in childhood.The treatment of children with high-risk NB is still very challenging.At present,the treatments of NB mainly concentrated in the surgery,chemotherapy,radiation therapy and transplantation technology,etc.In recent years,more studies focus on targeted therapy and molecular biology (genetics) treatment.Targeted therapy is targeted to different specific loci of tumor,so as to kill tumor cells and reduce the impact on the normal tissue,which supplies more safe and effective treatments for children with NB.