Biomedical Research ; trends ; Humans ; Liver Neoplasms

Antiviral Agents ; therapeutic use ; Carcinoma, Hepatocellular ; drug therapy ; virology ; Hepacivirus ; Hepatitis B virus ; Humans ; Liver Neoplasms ; drug therapy ; virology

Antiviral Agents ; therapeutic use ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Hepatitis B, Chronic ; drug therapy ; Humans ; Interferon-alpha ; therapeutic use ; Lamivudine ; therapeutic use ; Phytotherapy

Objective To investigate the antimicrobial susceptibility of Neisseria gonorrhoeae isolated from 10 cities of China, and to provide reference for the formulation of treatment guideline and making control strategy. Methods Agar dilution was used to detect antimicrobial susceptibility and acidometric method for PPNG testing. Results A total of 3186 gonococcal isolates were tested from 1993 to 1998. The resistant rate for penicillin was 66.70％ . PPNG isolates accounted for 8.14％ . Tetracycline－ resistant isolates accounted for 93.02％ , and high level tetracycline－ resistant isolates (TRNG) accounted for 4.65％ . The resistant rate for ciprofloxacin was also high (34.25％ ). The resistant rates for spectinomycin and ceftriaxone were 0.44％ and 0.57％ respectively. Conclusions The gonococcal isolates are highly resistant to penicillin, tetracycline, and ciprofloxacin, while still sensitive to spectinomycin and ceftriaxone. These results suggest that the present treatment for gonorrhea can still be used.

ObjectiveTo investigate the value of S100B protein in the evaluation of prognosis for patients with severe brain injury.MethodsThe serum S100B protein concentration was determined by enzyme-linked immunosorbent assay in 86 patients with severe brain injury(observation group) and 89 healthy individuals(control group) from February 2009 to March 2011.The clinical symptom and Glasgow outcome scale(GOS) score were measured.ResultsIn the 86 patients of observation group,33 patients were with good-recovery,25 patients were with moderate-deficit,14 patients were with severe-deficit,1 patient was detected of persistent vegetative status,and 13 patients died.The rate of excellent prognosis and worse prognosis were 67.4％ (58/86) and 32.6％ (28/86).The concentration of S100B protein was obviously higher in observation group [ ( 1.42 ± 0.42 ) μ g/L ] than that in control group [ (0.16 ± 0.05 ) μ g/L ] in 24 hours (P ＜ 0.01 ).The concentration of S100B protein in worse prognosis [ (2.15 ± 0.51 ) μ g/L] was obviously higher than that in excellent prognosis [ ( 0.92 ± 0.49) μ g/L ] ( P ＜ 0.05).ConclusionsS100B protein has high sensitivity and specificity to evaluate brain injury,and it is a reliable and valid biochemical marker of the brain damage.It has important clinical value in the evaluation of severity and prediction of prognosis for patients with severe brain injury.

ObjectiveTo explore the effect and surgical management of the internal fixation with double steel plate by the olecranon osteotomy approach in the treatment of severe condyle humeral intercondylar splintered fracture.Methods50 patients with severe condyle humeral intercondylar splintered fractures were treated by double plate internal fixation through olecranon osteotomy.ResultsAll patients(50 cases) were followed up for 6 months to 2 years.The complications such as bone defect,ossifyingmyositis,tardive ulnar nerve compression,and internal fixation fail were not found.According to Aitken Rorabeck scale,the function of the elbow showed excellent in 35 cases,good in 9 cases,fair in 6 cases,the excellent and good rate was 88％.ConclusionThe internal fixation with double steel plate by the olecranon osteotomy approach in the treatment of severe condyle humeral intercondylar splintered fracture was a good approach.Anatomical reduction surgically reconstructed stabilization of the elbow and early active rehabilitation were crucial factors of functional rehabilitation of the elbow.

Objective To explore the clinical diagnosis value of colonoscopy and pathological examination for the etiology of colon and rectum ulcer.Methods 120 patients with colorectal ulcer were examined by colonoscopy and pathological examination,and differential diagnosed.Results The rate of endoscopic diagnosis combined pathological diagnosis for ulcerative colitis,tuberculosis,crohn's disease,amebic,chronic bacterium dysentery were different from the endoscopic diagnosis rate and pathological diagnosis rate,the differences were significant (x2 =12.37,13.58,15.02,17.77,18.39,P ＜ 0.05 ) ; In the nausea lymphoma,colorectal cancer,endoscopic diagnosis combined pathological diagnosis with quite a statistically significant difference between the rate of endoscopic diagnosis( x2 =10.95,11.40,P ＜ 0.05 ).Conclusion For the colorectal ulcer disease,colonoscopy combined pathological examination was an ideal means of inspection.

Objective To investigate the reason for embolism in ulnar artery after the injury. Methods 32 cases with repaired ulnar arteries were studied after 3～6 months' countercheck, physical test and ultrasonography (US) were performed to examine the blood flow in ulnar arteries. Results Embolism occurred in 20 repaired arteries of 32 cases. Conclusion Embolism are prone to occur after the injury of ulnar artery.

Objective To probe the relationship on TCM syndromes and related index of metabolic syndrome.Methods 1124 people who receive physical examination were undertaken TCM syndrome differentiation,and five viscera syndromes,the deficiency syndromes,excess syndromes,cold and heat syndromes were found.The relations between TCM syndromes and waist circumference,triglycerides,high-density lipoprotein,blood pressure,fasting blood glucose were studied.Results ①The deficiency syndrome groups and the groups of metabolic syndrome related index by clustering analysis had a higher consistency.②Discriminated analysis demonstrated waist circumference,high-density lipoprotein,and diastolic blood pressure could be used to determine liver syndrome.Blood sugar could be used to determine kidney syndrome.Waist could distinguish blood deficiency syndrome.Blood glucose and systolic blood pressure could distinguish Yin deficiency syndrome.Systolic blood pressure could determine Qi stagnation syndrome.Siastolic blood pressure could determine heat syndrome.The liver syndrome group and the actual liver syndrome group had higher consistency by discriminated analysis.After establishing the discriminated equation,total correct rate of distinguishing were 57.3％,67.1％,63.8％,61.5％,52.4％,47.2％.③Receiver operating characteristic curve analysis showed that blood glucose had diagnostic significance to renal syndrome.The area under the curve was 0.562.Triglycerides,blood glucose,blood pressure had diagnostic significance to Yin deficiency syndrome.The areas under the curve were 0.541,0.556,0.580 and 0.569.Waist circumference,triglycerides,high-density lipoprotein had diagnostic significance to moisture syndrome.The areas under the curve were 0.622,0.609 and 0.605.Diastolic blood pressure had diagnostic significance to heat syndrome.The area under the curve was 0.544.Conclusion By the multifarious analytical methods,we can see that syndromes have more contacts to related index of metabolic syndrome.