Objective To explore the antagonistic effect of Schistosoma japonicum soluble adult worm antigen (SWA)and solu-ble egg antigen (SEA)in the mice with type 1 diabetes.Methods The 24 successful modeling type 1 diabetes mice were randomly divided into three groups (A,B,C group,n=8).SWA and SEA of Schistosoma japonicum were prepared.Mice in A group were immunized by abdominal subcutaneous multi-point injection SWA.Mice in B group were immunized by abdominal subcutaneous multi-point injection SEA.And mice models of C group were immunized by PBS instead of antigen through abdominal subcutaneous injection.The mice got immunization once a week,a total of four times.4 weeks later,the mice were sacrificed,and serum speci-mens were collected for the determination of serum levels of IL-4 and IFN-γby double-antibody sandwich ELISA,while pancreas tissues were collected and the pathological changes were observed.Results The serum IL-4 level of B group [(23.87 ±4.85)pg/mL]was higher than C group [(4.39 ± 0.56 )pg/mL],with significant differences (P < 0.01 ),while the serum IFN-γ level [(271.85±26.04)pg/mL]was lower than C group [(362.79 ±32.50)pg/mL],also with significant differences (P <0.01).The serum IL-4 and IFN-γof A group were (5.09±0.37)pg/mL and (379.56±34.47)pg/mL,which had no difference with C group (P >0.05).The islet structure of mice in B group was not intact,however,the lymphocytic infiltration in B group was less than C group,and there was no lymphocytic infiltration in pancreatic islets in B group.Compared with C group,the pancreas of mice in A group did not have significant changes,lymphocytes infiltration was still visible in islets.The number of residual islet cells de-creased,and visible minority islet structure was destroyed.Conclusion SEA of Schistosoma japonicum has certain antagonism effect on type 1 diabetes in experimental mice.Its mechanism may be the reduction of Th1 response and the enhancement of Th2 response through increasing IL-4 level and decreasing IFN-γlevel.

Basic research in interventional radiology,including transcatheter artery perfusion especially,is progressing slowly due to lack of proper method.Microdialysis technique,a kind of accurate sampling technique in vivo,may help to solve the problem.Just as its name implies,microdialysis means tiny dialysis with advantages of authenticity,exactness and less error.Furthermore it has been applied widely and should be received with great attention and popularity.

The articles concerning intensive effect and progress of interventional therapy for hepatocellular carcinoma (HCC) recurrence were comprehensively reviewed. Along with unceasing abundance of all interventional methods (including transcatheter arterial chemoemblization (TACE),percutaneous dehydrated ethanol injection,radio frequency ablation,percutaneous microwave therapy,argon-helium cryoablation,high-intensity focused ultrasound and radionuclide interventional therapy,etc),combined interven-tional therapies mainly TACE were increasingly appreciated in postoperative HCC recurrence,but still have to be further standardized. With further emerging and maturing of new technologies,such as antiangiogenesis,gene therapy and targeted therapy on HCC metastatic and recurrence specific cycle; the effect of combined therapy will be further promoted. Interventional therapy will play an important role in the prevention and treatment of postoperative HCC recurrence in the foreseen furture.

Objective: To explore the differences between the internal social adaptation and external social behaviors of freshmen. Methods: Make a survey of 198 freshmen on the internal adaptation and external by General Well-Being Schedule and Undergraduate Social Adaptation Questionnaires. Results:Freshmen' social adaptation mainly involves three factors: interpersonal communication, the state of campus life and performance of studies. The Cronbach alpha of 3 factors were 0.82, 0.87 and 0.90,and the re-test reliability was r=0.73 (P

The interventional therapy of chemoembolization is the first management of choice in treating unresectable hepatic carcinomas but with some side effects including liver function damage and bone marrow restraints which may affect the patients'life expectancy and living quality in the long run.The advancement of the combination of interventional treatment with Chinese drugs in managing liver carcinomas is a special presentation by the auther for further recommondation.

Objective:To study the cognitive features of text anxiety. Methods: The cognitive features of text anxiety were explored by exploratory factor analysis and confirmatory factor analysis on the basis of interview,questionnaire surveying and criterion.Results:There were 6 cognitive factors leading to test anxiety: self-test, worrying, magnifying conclusion, resistance, preparing, self-efficacy.Conclusion: The 6 factors of cognition about text are related to text anxiety

Objective: To investigate the safety and feasibility of Laparoscopic left hepatic lobe resection in the treatment of bile duct stones. Methods: Eighty cases in our hospital with bile duct stones for left hepatic lobectomy were randomly divided into control group and experimental group. The control group was received open left hepatic lobectomy. The experimental group was received laparoscopic left hepatic lobectomy. The operative time, incision length, blood loss, hospital stay, hospital costs and incidence of postoperative complications were compared of two groups. Results: The incision length and length of hospital stay of experimental group was significantly shorter than control group. The difference was statistically significant (t=4.46, t=5.38; P<0.05). While operative time, blood loss, hospital costs and postoperative complication rate of two groups showed no significant difference (t=0.32, t=0.73, t=0.37; x2=0.47; P>0.05). Conclusion:Laparoscopic left hepatic lobe resection is safe and feasible in the treatment of bile duct stones with the advantage of less trauma and quicker recovery. It’s worthy of clinical widely used.

In recent years,with the establishment of neonatal intensive care unit and the development of nutritional support,the survival rate of very low birth weight infants has increased significantly.As more and more premature infants and low birth weight infants have been rescued alive,more attention has been paid to the follow-up growth of preterm children as well as the related impact factors in prenatal medicine.The most effective way to evaluate the effects of the nutritional support and medical decision has made on the premature infants,the postnatal Physical development of preterm infants after birth,including height,weight,head circumference and IBM,should be recorded and studied.This article reviews the current studies of follow-up of preterm infants at various growths stages,as well as the catch-up growth and long-term development.

Objective To investigate the clinical effects of early cranioplasty and ventriculoperitoneal shunt in the treatment of traumatic brain injury.Methods 70 patients with traumatic brain injury were randomly divided into two groups.35 cases in the control group were treated with ventriculoperitoneal shunt,and received cranioplasty postoperative 3-6 months.35 patients in study group received early cranioplasty and ventriculoperitoneal shunt in 2-3 months after treatment.The therapeutic effects of the two groups were observed.Results After GCS,the excellent and good rate of study group was 71.4％,which was significantly higher than 57.2％ of the control group (x2 =7.47,P ＜ 0.05).The good rate of the study group was significantly higher than that of the control group (x2 =8.35,P ＜0.05).The moderate disability rate of the study group was significantly lower than that of the control group (x2 =7.33,P ＜0.05).The incidence rate of complications in the study group was 14.3％,which was significantly lower than 34.3％ in the control group (x2 =7.35,P ＜ 0.05).Conclusion Early cranioplasty and ventriculoperitoneal shunt therapy in the treatment of patients with traumatic brain injury can effectively improve clinical recovery of the patients,and reduce the postoperative complications.

MicroRNA,a type of small non-coding RNA specialized in regulation of gene expression,extensively participates in biological cell development,differentiation apoptosis and other cellular processes.Studies have shown that microRNA plays vital regulatory roles in epilepsy.Its mechanisms include regulation of inflammatory responses,proliferation of glial cells,the reconstruction of the synaptic contact and pro-apoptotic gene expression.This article reviews the molecular mechanisms of microRNA in regulation of epilepsy and the possible regulatory roles of microRNA in other nervous diseases.