ObjectiveTo determine the diurnal variation,moon phase,and seasonal variation in the onset of stroke. MethodsThe time parameters,including the time,the moon phase and the season of the stroke occurrence for 905 in-patients from 1989-2001 were investigated.ResultsThere was a significant difference (D=0.155,P<0.01) for circadian rhythm in the onset of 321 cases with cerebral infarction,and the incidence frequency at dawn was much higher than that at other time,but the difference of the moon phase and seasonal rhythm in the onset of cerebral infarction were not significant(P>0.05).There were not diurnal variation,moon phase and seasonal rhythms in the onset for cerebral haemorrhage(P>0.05).ConclusionsThe cerebral infarction occur more frequently at dawn time.

Objective To investigate the efficacy and safety of perioperative application of ambroxol in lobectomy for protecting pulmonary function,in order to provide reference for clinical treatment.Methods 684 patients who received lobectomy operation were selected ,they were randomly divided into the control group (358 cases) and therapy group(326 cases).Patients of control group were treated with regular therapies ,while patients of therapy group were treated with ambroxol(10mg· kg-1· d-1).Pulmonary function,SOD,PAF,SP-A,complications were compared between the two groups .Results Before treatment ,FVC and FEV1 between the two groups had no significant differ-ences(P>0.05);FVC and FEV1 in the two groups decreased after treatment ,but the control group decreased more significantly (t=5.993,P=0.017;t=5.493,P=0.021);48h after the surgery,SOD,PAF,SP-A of therapy group were (1 259.23 ±320.43)μg/L,(11 521.38 ±2 193.43) mu/mL,(206.38 ±9.22) ng/L,which were better than those of the control group(t=8.329,P=0.001;t=4.394,P=0.025;t=6.943,P=0.008).The incidence rate of complication in therapy group was 8.10%,which was significantly lower than 20.55% in the control group (χ2 =8.932,P=0.000).Conclusion Ambroxol has better efficacy and safety in lobectomy perioperation for protecting pulmonary function ,and its anti-inflammatory performance is better .

With the development of diagnosis and treatment,esophageal replacement is required by more and more patients. Esophageal scaffold materials are focus on titanium-nickel alloy,polyethylene,polymer silica gel terylene composite,carbon fiber,and some biomaterials. However,those materials have poor biocompatibility and mechanical compatibility,resulting in high incidence of complications,such as anastomosis fistula,detachment of tube,and stenosis and poorly clinical effect. Whereas,implantation of esophageal scaffold is hopeful for solving the problems mentioned above. Here,we investigate the development and application of esophageal scaffold materials based on tissue engineering technique.

Objective To study the effect of CpG containing oligodeoxynucleotide(CpG-ODN) on the phenotypes,function and expression of signal transductors and activators of transcription(STAT) and suppressors of cell signaling(SOCS) of peripheral blood dendritic cells(DC) in patients with chronic hepatitis B(CHB).Methods Monocytes isolated from peripheral blood of CHB and healthy volunteers were cultured and induced by granulocyte-monocyte colony stimulating factor(GM-CSF) and interleukin-4(IL-4).Then,CpG-ODN or TNF-? were added to stimulate the immatured DC,their effects on the phenotypes and function of DC were evaluated.(The expression of) signaling molecules of STAT1,3,4,5,6 and SOCS1,3 in DC were detected by Western blotting.Results The(expression) rates of HLA-DR of DC in CHB with the treatment of CpG-ODN or TNF-? were obviously increased;Both the IL-12p70 expression and stimulating capacity of DC to allogenic T lymphocytes were improved significantly in CpG-ODN group and TNF-? group(P

Objective To study the effects of the RNA secondary structure on the RNA interference efficacy and to optimize the RNAi target sequence selection.Methods N-Ras mRNA in K562 human chronic erythro-leukemia cell line was selected as the target for RNAi experiments.Four siRNAs were designed aiming at secondary structure region and none-secondary structure region separately.The N-Ras expression change and the cell growth was tested by semi-quantitative reverse transcription polymerase chain reaction(RT-PCR),light microscopy,MTT,and flow cytometry.Results Knock-down efficiency was recorded in all of the 4 experiment groups,but the degree varied a lot.The siRNAs targeting none-secondary structure region presented higher silencing efficiency than those targeting secondary structure region.Conclusion The secondary structure of mRNA closely relate to the RNA interference efficiency,which should be considered in the processing of the target sequence selection.

Objective To compare the value of syngo RESOLVE DWI and conventional full field-of-view (f -FOV)DWI in the diagnosis of ovarian tumors with 3.0T MRI scanner.Methods 21 consecutive patients with ovarian tumors confirmed by operation and pathology were selected.All patients underwent routine MRI plain scanning,RESOLVE DWI and f -FOV DWI with a 3.0T MRI scanner.ADC values measured the RESOLVE and the traditional DWI images of ovarian tumors,used the method of four points by two imaging diagnostic doctors to image the display effect of ovarian tumor in subjective ratings.SPSS 13.0 software was used for statistical analysis.Results The subjective score of tumors ovarian showing of RESOLVE DWI was (3.62 ±0.44)points,which of f -FOV DWI was (2.93 ±0.51)points,there was statistically significant difference(Z =-3.787,P <0.05);The average ADC value of ovarian tumor in RESOLVE DWI was (0.824 ±0.157)×10 -3 mm2 /s,that in f -FOV DWI was (0.775 ± 0.147)×10 -3 mm2 /s,there was no statistically significant difference(t =1.038,P >0.05).Conclusion In ovarian tumor MRI DWI examination,compared with f -FOV DWI,RESOLVE DWI can obtain higher space resolution,higher image quality,and obtain accurate quantitative parameter values.

OBJECTIVE:To observe the effect of ulinastatin on related parameters of patients with successful cardiopulmonary resuscitation (CRP) after cardiac arrest but concurrent post-resuscitation syndrome (PRS). METHODS:76 patients with successful CRP after cardiac arrest and PRS were randomly divided into test group and control group. Control group was given conventional treatment;test group was additionally given ulinastatin 200 000 U adding into 0.9% Sodium chloride injection 20 ml by intrave-nous injection,every 12 h. The treatment course was 7 d for 2 groups. The myocardial enzyme parameters (m-AST,HDBH and CK-MB)in ROSC immediately,24 h,48 h and 72 h,renal function parameters(Cr,BUN);predictors of disease(ALB and Lac) and incidence of adverse reactions and survival rate in 2 groups were observed. RESULTS:All above-mentioned parameters in 2 groups showed flutuations in ROSC immediately,and test group was better than control group,the differences were statistically sig-nificant(P<0.05);patients with adverse reactions in test group were significantly less than control group,survival rate was signifi-cantly higher than control group,the differences were statistically significant(P<0.05). CONCLUSIONS:Ulinastatin can effective-ly control the inflammatory response factor of PRS patients,improve parameters of critical illness and survival rate.

The topic about academic power and administrative power of the university is a focal point to debate unceasingly in the educational circles.According to the discrimination of the conceptions,the article analyzes their rationality and limitation,and proves that academic power and administrative power are often in the relationship of the division of labor and cooperation,cooperation mutually,and interdependence.

Objective To explore the application value of blood lipid,blood glucose,liver function and serum uric acid in the diagnosis of fatty liver in elderly patients.Methods A total of 62 elderly patients with fatty liver in our hospital from April 2016 to October 2016 were selected as study group,and 62 healthy persons were selected as control group.All the subjects were drawn fasting venous blood 4 mL.Rate method was used to detected liver function indexes of total bile acid(TBA),gamma glutamyltranspeptidase(GGT) and aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL) levels.The hexokinase method was used to detected blood lipid indexes,including very low density lipoprotein cholesterol(VLDL-C),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),cholesterol(TC),triglyceride(TG) levels.The peroxidase colorimetric method was used to detected blood glucose index including glycated hemoglobin(HbA1c) and fasting blood glucose(FBG) levels.MINDRAY BS-400 automatic biochemical analyzer produced in Shenzhen MINDRAY company was used to detect the serum uric acid level.Value of blood lipid,blood glucose,liver function,serum uric acid in diagnosis for fatty liver were made statistical comparison.Results The levels of TBA,GGT,AST,ALT and TBIL in the study group were higher than those in the control group,the level of VLDL-C,LDL-C,TG,TC in the study group were higher than those in the control group,the HDL-C level was lower than that in the control group,the levels of FBG and HbA1c in the study group were higher than those in the control group,the level of serum uric acid in the study group[(447.12±91.03)μmol/L] was higher than that in the control group [(353.41±70.32)μmol/L],the differences were all had statistically significant(P<0.05).The sensitivity(80.65%,79.03%,82.26%,77.42%) and accuracy(90.32%,88.71%,90.32%,88.71%) of blood lipids,blood glucose,liver function,blood uric acid alone in diagnosis of fatty liver were lower than the combined diagnosis(95.16%,96.77%),the differences were statistically significant(P<0.05).Conclusion Fatty liver patients have abnormal blood lipids and blood glucose,liver function and blood uric acid level,combined with the above indexes for diagnosis can improve the sensitivity and accuracy of fatty liver,and provide guidance for the intervention,is worthy of promotion.

Gastrectomy ; Gastroenterostomy ; Humans ; Laparoscopy ; Reconstructive Surgical Procedures ; Stomach Neoplasms