The prevalence of inflammatory bowel disease( IBD)increases every year in our country. Endoscopy combined with histopathological examination can contribute to the diagnosis of IBD,however,it is an invasive and complex procedure. Finding a simple and accurate diagnosis method has been an eager task. Serological antibodies detection has an important guiding value for the diagnosis of IBD. This article reviewed the clinical significance of detection of serological antibodies in patients with IBD.

BACKGROUND:Because of the deficiency of researches on connective tissue growth factor associated with orthopedic diseases, very little attention has been paid to the studies on connective tissue growth factor in the intervertebral disc.
OBJECTIVE:Through exploring the role and mechanism of connective tissue growth factor in disc degeneration, to provide new evidence for biotherapy of disc degeneration.
METHODS: A computer-based search of PubMed and CNKI was performed by the first author to retrieve articles relevant to the effect and mechanism of connective tissue growth factor on degenerative disc and its related tissues published from January 1997 to October 2014. The keywords were “intervertebral disc; CTGF; TGF-β;hypoxia; disc degeneration” in Chinese and English, respectively, which appeared in the title, abstract or keywords. Articles published recently or in authoritative journals were preferred, and finaly 34 articles were included in result analysis.
RESULTS AND CONCLUSION:Recentlyin vivo and in vitro studies on the intervertebral disc have clearly demonstrated the anabolic role of connective tissue growth factor in stimulating matrix production from nucleus pulposus cels and revealed that the transforming growth factorβ-connective tissue growth factor axis was of great importance to celular matrix productionviaregulations and stimulations to transforming growth factor β and hypoxia, while the regulation of hypoxia for connective tissue growth factor was another in a specific cel and tissue manner.

The era of targeted molecular therapy for cancer has arrived. The mechanisms of targeted molecular drugs are different from those of chemotherapy drugs. The tumor response evaluation criteria that we currently use are the summary of experiences from evaluating the effect of chemotherapy drugs. Despite continuous improvement and standardization of the details, tumor response evalua-tion criteria, from the earliest WHO criteria to the improved RECIST and RECIST 1.1 criteria, are all based on measurement of tumor size, as chemotherapy drugs directly kill tumor cells. The aforementioned criteria are outlined in this review. However, targeted molecu-lar drugs mainly inhibit tumor cell proliferation. The effect of targeted molecular drugs on tumors is different from that of chemothera-py drugs. Thus, tumor response evaluation criteria suitable for targeted molecular drugs have been developed in recent years. This re-view introduces Choi criteria that use CT attenuation coefficient (Hounsfield unit [HU]) to describe tumor density. The criteria have measured indicators that include tumor size and tumor density. This review also introduces the following criteria derived from the Choi criteria for Modified Choi (mChoi) criteria size and attenuation CT (SACT), and morphology, attenuation, size, and structure (MASS).

In order to further promote friendly cooperation with developing countries, Chinese government has been committed to increasing the intensity of cooperation and human resource development among developing countries. Healthcare is one of the key areas of China’s foreign aid. This article described the general conditions and experiences of national foreign aid training projects for developing countries undertaken by the Beijing Traditional Chinese Medicine Hospital and Beijing Traditional Chinese Medicine Research Institute. From aspects of participant enrollment, training program implementation, and training feedback, the training mode of national foreign aid on traditional medicine was introduced. This article focused on the selection of teachers, preparation of professional textbooks, and evaluation of teaching quality. Training programs over the years were guided by clear training concepts and accurate goal settings, which provided a useful exploration for the personnel training mode of national foreign aid on traditional medicine.

Fifty cases of acute lumbar sprain were treated by the combination of acupuncture, cupping and kinesitherapy. Forty-three cases were cured and 7 cases improved, the total effective rate being 100%. This therapy has an exact effect with a short course of treatment.

OBJECTIVE To investigate the genetic polymorphism of imipenem-resistant Pseudomonas aeruginosa by randomly amplified polymorphic DNA(RAPD). METHODS The genes of imipenem-resistant P.aeruginosa were amplified by RAPD assay in 8 clinical isolates and PCR products were analyzed by agarose gel electrophoresis and cluster analysis. RESULTS The phenotypes of drug resistance were the same,but most of the genotypes were different,even though some of them could be equal. CONCLUSIONS RAPD assay reveals the special genotypes of imipenem-resistant P.aeruginosa and makes the relation between the phenotype of drug resistance with genotype of drug resistance definite,which provides molecular epidemiological evidence for strategies to control resistant imipenem P.aeruginosa infections.

OBJECTIVE To investigate the resistance of Pseudomonas aeruginosa isolated from two hospitals and its chlorhexidine-sulfadiazine-resistant genes(qacE△1-sul1). METHODS Microdilution tests were performed to detect the susceptibility of 66 strains of P.aeruginosa to 6 kinds of antimicrobial agents.The qacE△1-sul1 gene was analyzed by PCR. RESULTS The resistant rates to other antimicrobial agents were between 12.5-87.5%.qacE△1-sul1 gene was 50.0%. CONCLUSIONS The 66 strains are multiple-drug-resistant.There are very high positive percentages of qacE△1-sul1 gene in P.aeruginosa isolated from two hospitals.

Entry of enveloped viruses into host cells requires fusion of the viral envelope with a cellular membrane. This step is mediated by viral glycoproteins that undergo a dramatic conformational change. Recent advances in structure and function of the fusion proteins of the class Ⅱ viruses, Rhabdoviruses and Herpesviruses were described. Proteomics computational analyses to locate the functional domain of fusion protein were introduced. The fusion proteins of class Ⅱ and class Ⅰ viruses differ radically in their initial structures but refold toward similar final conformation (trimer of hairpin). The Rhabdoviruses and Herpesviruses have a novel fold combining features of fusion proteins from class Ⅰ and class Ⅱ. The fusion proteins of these viruses have a different conformation change and mediate a different fusion process, therefore, the proteins belong to a novel class of fusion proteins. The potent inhibitor of virus entry should be new strategies for developing antiviral drugs.

This paper introduces an intelligent vision analysis system for urinary sediments,which includes the function modules of mechanical,automatic adding sample and cleaning,images collecting,processing and intelligent vision recognition,system software and so on.It implements the course of adding sample,cleaning,images collecting,feature extraction,recognition and counting,self-learning automatically.

Only realizing part of work in fixed assets management department, hospital account of fixed assets management system is unable to integrate the equipment using,management and finance departments. While the bar code management system can merge three departments into one system and manage the fixed assets of hospital with consistency of accounts, card and equipment.