Introduction: Gout is one of the most common inflammatory arthritis in Malaysia. It is due to persistent hyperuricemia that leads to the formation and deposition of intra- and periarticular monosodium urate crystals either due to excessive production or insufficient excretion of uric acid. Incidence and prevalence of gout is increasing worldwide, with a higher rate among men compared to women. Malay is the largest ethnic group in Malaysia, followed by Chinese and Indian. SLC2A9 is a renal urate transporter that controls renal uric acid excretion and genetic variants in SLC2A9 are associated with the risk of gout in several populations. This study aimed to test if the SLC2A9 variant (R265H, rs3733591) is also associated with gout among Malays in Malaysia. Methodology: A total of 89 patients with gouty arthritis and 100 normal subjects who consented and were recruited in this study. The serum urate and creatinine were measured. The SNP genotyping was performed using PCR-RFLP method for rs3733591 and BST 1236 was used as a restriction enzyme to cut the targeted amplicons. Result: SLC2A9 variant was associated with gout, p-value of 0.007, OR=4.713 [95%CI 1.530-14.513], however this association was not significant after adjustment for age and gender with p=0.465 (OR=1.950; 95%CI[0.325-11.718]). Conclusion: Our data suggest that the genetic variant of SLC2A9 may contribute to the susceptibility of gout among Malays in Malaysia.

Objective:To find out if AHEAL cream is effective in the prevention and treatment of halitosis. Methods:Forty-six patients were randomly assigned to either experimental group or control group. At baseline examination,each patient was asked to fill in a format to assess the halitosis by himself. An instrument named Halimeter was used to demonstrate the value of halitosis. After 2,4 and 8 weeks of intervals,all the index were reassessed. Results:There was significant difference between two groups after 2 weeks of interval using the Halimeter instrument to assess halitosis,while significant difference was found out in the format filled in by the patients after 4 weeks. Conclusion:AHEAL cream is somewhat effective for the prevention and treatment of simple gingivitis.

Immunofluorescent technique with slide solid phase antiboby was used for the detection of Coxiella burnetii. The experimental conditions and the specificity of this new technique were compared with those of the conventional immunoiluorescent technique. Both techniques were used to examine the specimens of infected Orni-thodoros moubada and the results were also compared. It was found that when the new technique was used to detect C. burnetii, the non-specific fraction of the fluorescence in the specimen was significantly decreased and the sensitivity to the extracellular antigen was not affected.

Objective To investigate the relationship between carotid artery intima-media thickness(IMT) and blood pressure(BP) as well as QT dispersion in 18 - 35 young people. Methods Body mass index (BMI) and BP of 107 people in 18 - 35 years of age were measured, the carotid artery was also detected by 2-dimensional and color Doppler ultrasound. According to BMI,a]I candidates were divided into group A(norrnal BMI) and group B(obesity), then the relationship between IMT and BP, QT dispersion were analyzed. Results Compared with group A,BP,IMT,QT dispersion in group B were increased, there was significant diference between the two group (P <0.05). Relationship was positive correlative between IMT and systolic BP(LIMT: r=0.224, P=0.021;RIMT:r=0.193,P=0.047) ,but negative correlative between IMT and diastolic BP(LIMT: r=0.123, P=0.210; RIMT: r=0.138, P=0.159). The risk estimate of abnormal IMT was higher when QT dispersion >50 ms than that ≤50 ms(OR=6.223, P<0.05). Conclusions The systolic BP is positive correlative with IMT of carotid artery at age 18-35,increasing QT dispersion is a high risk factor of abnormal IMT. IMT should be detected when QT dispersion >50 ms and systolic BP >120 mm Hg.

AIM: To determine the effects of anisodamine (Ani) administered intraperitoneally on the gastric mucosal lesion induced by reserpine.METHODS:In reserpine-treated rats, gastric mucosal lesion, gastric acid secretion, gastric barrier mucus secretion, gastric contraction, gastric mucosal blood flow (GMBF), gastric mucosal nitric oxide synthase (NOS) activity and nitric oxide (NO) content were examined.RESULTS:Ani in doses of 1,5 and 10 mg/kg significantly inhibited the formation of gastric lesions induced by reserpine, with the suppressive rate of 60.0%, 66.7% and 76.6%, respectively. Ani (10 mg/kg) significantly inhibited the secretion of gastric acid, but had no effect on the volume of gastric juice. Ani (10 mg/kg) significantly prompted the secretion of gastric barrier mucus. Our findings also showed that Ani (10 mg/kg) significantly suppressed the frequency and amplitude of gastric contraction. Ani (10 mg/kg) significantly prompted GMBF. In reserpine treated rats, gastric mucosal NOS activity and NO content were decreased and Ani (10 mg/kg) could inhibit the decrease in NOS activity and NO content.CONCLUSIONS:The protective effect of Ani may results in part from inhibiting gastric acid secretion, prompting gastric barrier mucus secretion, suppressing gastric contraction and improving GMBF. NO seems to play an important mediator role in the Ani protective mechanisms.

OBJECTIVE:To promote the innovation and communication of the traditional Chinese medicine knowl-edge.METHODS:Being a burgeoning network technology,Blog was adopted to construct the platform for the innovation and communication of the traditional Chinese medicine knowledge and Blog was compared with the other network plat-forms.RESULTS&CONCLUSION:Being a personalized individual knowledge management system,Blog has been noted with great interest by the academic circle in our country.Blog plays a big role in the innovation and platform construction of the traditional Chinese medicine knowledge.

Objective To observe the effects and toxicity of paclitaxel liposome combined with cisplatin in the treatment of ad-vanced non-small cell lung cancer .Methods 80 cases of patients of advanced non-small cell lung cancer were randomly divided into study group and control group ,40 cases in each group .Study group was treated with paclitaxel liposome (135 mg/m2 ,IV drip 3 h , first days) ,control group received paclitaxel(135 mg/m2 ,IV drip 3 h ,first days) ,the two groups combined with cisplatin 75 mg/m2 ,IV drip ,for 3 days ,take 21 days as one cycle .Results The study group CR 0 .0% (0/40) ,PR 27 .5% (11/40) ,RR 27 .5% (11/40);control group CR 0 .0% (0/40) ,PR 25 .0% (10/40) ,PR 25 .0% (10/40) ,(P>0 .05) .The research group of rash ,muscle and joint pain ,peripheral neuropathy was significantly lower than that of the control group (P<0 .05) .The research group of progres-sion-free survival was 5 .3 months(95% CI 3 .713 -6 .408) ,the median survival period was 9 .3 months(95% CI 8 .337 -9 .907);control group of progression-free survival was 4 .6 months(95% CI 3 .187 -5 .547) ,the median survival period was 9 .4 months (95% CI 7 .787-11 .602) ,the two groups had no statistical significance (P>0 .05) .Conclusion Paclitaxel liposome combined with cisplatin in treatment of advanced non-small cell lung cancer clinical efficacy and long-term efficacy of taxol and quite ,but with less allergic reaction .

The researches on ocular dominance have been continuing deeply last decade years since the concept was first described by means by Porta in 1593.Based on the neurophysiology and molecular biology,it is confirmed that the procedure of ocular dominance involves sublayer 4C of the visual cortex,N-Methyl-D-aspartate (NMDA)-receptor,a-calmodulin kinase Ⅱ (aCaMK Ⅱ),synapses and about candidate gens.Meanwhile,ocular dominance theory plays an important guiding role in optometry,laser-assisted in situ keratomileusis and cataract operation.In this review,the mechanism and clinical application of ocular dominance were summarized.

Objective To study the non-drug treatment factors which affecting the control rate of hypertension in the elderly. Methods A questionnaire survey was made in total 260 cases 60～83 years old hypertensive patients in Beijing Normal University. Results Among the hypertension patients, who under 70 years old ,female, nonsmoker and those with stage 1 hypertension, a short duration of hypertension and non-diabetes-hypertension have higher control rate (P<0.05). Conclusions Actively intervening plan for the risk factors and rationally utilizing the non-drug treatment in the people greatly improve the control rate of hypertension.