2.The research progress of relationship between endoplasmic reticulum stress and hepatocellular carcinoma
Journal of Medical Postgraduates 2017;30(6):669-672
The process of unfolded or misfolded proteins accumulated in the endoplasmic reticulum lumen termed endoplasmic reticulum stress (ERS), which can result in a variety of prevalent disease, such as autoimmune diseases, neurodegenerative diseases, metabolic disorders and cancer.In order to alleviate the pressure of ERS, eukaryotic cells produce a kind of adaptive intracellular signaling pathway which we called unfolded protein response (UPR, which main role is to remove misfolded proteins and restore endoplasmic reticulum homeostasis.However, apoptosis will be trigger if ERS increases continuously.There are many endoplasmic reticulum in Liver cells, the development of liver cancer is closely related to ERS and apoptosis.Therefore, finding a new method for the treatment of liver cancer in theory from the ERS induced apoptosis pathway seems so meaningful.
3.EXPERIMENTAL STUDY OF DEGENERATION OF PATELLAR CARTILAGE CAUSED BY ELONGATION OF PATELLAR LIGAMENT IN RABBITS
Chinese Journal of Sports Medicine 1983;0(03):-
Twenty-four rabbits' patellar ligaments were elongated 3 mm surgically, which decreased the pressure of the patellar articular cartilage. The pathological changes of cartilage and subchondral bone of the patellar were examined by light microscope and scanning electron microscope sequentially. 4 weeks after the surgery, proliferation of blood vessels in the subchondral bone and their invasion into the calcafied cartilage were seen, without abnormality in the patellar articular cartilage. After 8 weeks, irregularity of the tide mark and cartilage cells column, and peripheral part of the cartilage showed cluster formation. After 12 weeks, degeneration extended to the superficial layer of the cartilage, producing blister formation, fibrillation and a decrease in the thickness of the cartilage. These findings were similar to the histological changes of chondromalacia patellae. It was further suggested that decrease of pressure on the cartilage could be considered to be one of the causes for articular cartilage injury, and patella alta be correlated with chondromalacia of the patella.
8.Research progress on clinical factors for predicting radiation pneumonitis
Chinese Journal of Radiation Oncology 2021;30(3):305-310
Radiation pneumonitis (RP) is the most common adverse event of thoracic radiotherapy, which primarily occurs within the 3 months after the beginning of radiotherapy. RP can not only negatively affect the pulmonary function and quality of life of patients, but also limit the prescribed dose and the implementation of radiotherapy plan, lower the radiotherapy efficacy and even lead to death. Currently, multiple studies have been conducted to explore the predictive factors of RP. In this article, clinical predictive factors including dosimetric parameters, peripheral blood cells along with cytokines and pulmonary function parameters were classified and illustrated, aiming to provide valuable predictive indicators for clinical use and reduce the incidence of RP.
9.A valve type puncture needle.
Chinese Journal of Medical Instrumentation 2005;29(3):219-219
Equipment Design
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Humans
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Needles
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standards
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Paracentesis
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instrumentation
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methods
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Pleural Effusion
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therapy
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Pneumothorax
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therapy
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Punctures
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instrumentation
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methods
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Treatment Outcome
10.Violence: a problem of health equity and people's right to safety.
Chinese Journal of Epidemiology 2004;25(1):1-2
Child
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Child Abuse
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legislation & jurisprudence
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prevention & control
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China
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Delivery of Health Care
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organization & administration
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Domestic Violence
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legislation & jurisprudence
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prevention & control
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Female
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Human Rights Abuses
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legislation & jurisprudence
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prevention & control
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Humans
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Violence
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legislation & jurisprudence
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prevention & control
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World Health Organization
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organization & administration