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Objective To evaluate the diagnostic value of small probe endoscopic ultrasonography and to explore the clinical value of endoscopic mucosal resection(EMR)for esophageal small leiomyoma.Methods A total of 46 patients who diagnosed with esophageal SMTs by endoscope and EUS were selected,who were demanded endoscopic resection,and the clinical data and treatment outcomes of them were retrospectively analyzed.Results As showed by EU,40 cases of the total 46 cases were originated from mucosal muscularis,5 cases were originated from sub mucosal,and 1 case was from the muscularis propria layer.A total of 40 cases received EMR with complete excision,4 cases received ESD,2 cases received surgical treatment.Examinations of histopathological and immunohis-tochemical confirmed that the lesions were leiomyomas;both the lateral and basal margins of the specimens were free of tumor cells.None of the patients developed delayed bleeding or perforation.No tumor residual or recurrence was found during follow-up(rangeed 1 -12months).Conclusion EUS is an effective method for diagnosing esophagus submucosal tumors,and EMR could be a preferred treatment for small esophagus leiomyoma.

Objective To study the related factors of arrhythmia in patients with different types of coronary heart disease(CHD).Methods 330 patients with coronary heart disease were studied,including acute coronary syn-drome(ACS)of 210 cases (ACS group)and chronic ischemic syndrome (CIS)in 120 patients(CIS group).The slow arrhythmia occurrence types were detected by the dynamic electrocardiogram(DCG),and analyzed the correlation of different types of CHD occurrence of arrhythmia and serum brain natriuretic peptide BNP,left ventricular ejection fraction(LVEF),LVDD,serum potassium level and the number of diseased coronary artery.Results There were no significant differences in the incidence of atrial arrhythmias and ventricular arrhythmias between the two groups(χ2 =0.982,2.136,all P>0.05),and there were no significant differences in the proportion of all kinds of arrhythmia(all P>0.05).ACS patients with arrhythmia types and BNP and LVEF,LVDD level and coronary artery lesion counts had no significant differences(χ2 =0.044,0.061,0.347,all P>0.05).Related to the type of arrhythmia and serum potassium levels,patients in a low blood potassium levels,the incidence of ventricular arrhythmias increased signifi-cantly(χ2 =4.376,P<0.05).And increased BNP level,LVEF decreased and LVDD,atrial arrhythmias occurred rate were significantly higher than those of ventricular arrhythmias(all P<0.05),gradually increased with the number of diseased coronary artery,cardiac arrhythmia occurred rate increased.CIS patients arrhythmia type with BNP and LVEF,LVDD level (all P <0.05 ).And elevated BNP levels,LVDD and LVEF decreased levels increased and ventricular arrhythmia occurrence rate was significantly higher than that of the atrial arrhythmia(χ2 =5.811,5.968, 4.060,all P<0.05).The rhythm types of arrhythmia and serum potassium levels and coronary artery disease variable count had no significant difference(χ2 =2.336,P>0.05).Conclusion The arrhythmia types of ACS are irrelevant with BNP,LVEF,LVDD and coronary artery lesions,and hypokalemia patients prone to ventricular arrhythmia.CIS is related with BNP increase,LVEF decrease and LVDD increase,prone to ventricular arrhythmias,low blood potassium patients prone to atrial arrhythmias.

OBJECTIVE:To probe into the utilization of cardio-cerebrovascular Chinese patent medicines in our hospital to ensure safe, effective and economical use of which in patients. METHODS:The yearly consumption sum and quantity of cardio-cerebrovascular Chinese patent medicines during 2004～2006 in our hospital were investigated, and the utilization of which were analyzed applying DDDs analytical method.RESULTS:The consumption of cardio-cerebrovascular Chinese patent medicines during 2004～2006 in our hospital showed an upward trend. CONCLUSION:The use of Chinese patent medicine in our hospital is rational on the whole, with cheap and effective Chinese patent medicines assuming a dominant role in the clinical drug use.

OBJECTIVE: To observe the neuroprotective effect of Baicalein on H2O2-induced PC12 injury.METHODS: The PC12 cells cultured in vitro were preincubated with BAI for 24 h before being duplicated into the irreversible oxidative damages model with 500 ?mol?L-1 H2O2,then the protective effect of BAI (BAI presence or withdrawal) on these damaged cells in vitro was observed. The cell activity was detected by MTT microcolorimetry, and the lactate dehydrogenase(LDH) level in supernatant was determined as well. RESULTS: After pretreatment with BAI for 24 h,the injury of PC12 cells was significantly lessened in the presence or withdrawal of drugs in modeling, especially in the presence of drugs. Microscopically, PC12 cells can be seen with fuzzy edge and increased size, and cell fusion occurred in the BAI-treated H2O2 injury model. Cell activity increased,LDH level in the medium decreased, which were significantly different as compared with the model group. CONCLUSION: BAI can significantly reduce the hypoxic-ischemic injury of PC12 cells. Its mechanism may be related to its ability in reducing the accumulation of free radicals induced by blockage of the respiratory chain, antioxidation and free radical scavenging.

OBJECTIVE:To develop autocorrection data processing program for fourfold table Chi-square test program based on Excel.METHODS:Formatted fourfold table Chi-square test auto-analyzer procedure was established based on Excel.If total samples were no less than 40 and the theoretical frequency was no less than 1,Chi-square value and probability value could be obtained by using Pearson's Chi-square formula and Yates' Chi-square correction formula,otherwise,the values will be calculated by revising form cell citation based on Fisher's exact test.RESULTS & CONCLUSIONS:Fourfold Chi-square test can be realized based on Excel,furthermore,once formatted worksheet is fixed,Chi Square value can be obtained as long as sample values in worksheet are replaced.

OBJECTIVE:To evaluate the cost-effectiveness of Tanshinone capsule versus Gonglao quhuo tablet in treating acne vulgaris.METHODS: The cost-effectiveness of Tanshinone capsule versus Gonglao quhuo tablet in treating acne vulgaris(60 cases) was analyzed.RESULTS: The total effective rate,the cost and the cost-effectiveness ratio in Tanshinone capsule group were 93.33%,354.14 Yuan and 3.79 respectively versus 96.67%,212.94 Yuan and 2.20 respectively in Gonglao quhuo tablet group.CONCLUSION:Gonglao quhuo tablet is more economical than Tanshinone capsule in treating acne vulgaris.

OBJECTIVE:To explore the effect and impact of pharmaceutical care of traditional Chinese medicine on patients' compliance.METHODS:The influencing factors of patients' noncompliance and the effect of hospital pharmaceutical care in improving patients' compliance were analyzed.RESULTS:Patients' compliance is the pacing factor to maximize therapeutic efficacy,and in which satisfactory pharmaceutical care is indispensable.CONCLUSION:Hospital pharmaceutical care is conducive to the communication between doctors and patients or among clinical pharmacists,and it can help enhance patients' compliance and promote rational drug use.

OBJECTIVE:To discuss the general pattern and characteristics of adverse drug reactions (ADR) induced by rabies vaccine. METHODS: A total of 156 ADR cases induced by rabies vaccine were retrieved from China Hospital Digital Library and China Pharmaceutical Abstract between Jan. 1995 and Nov. 2008 and analyzed statistically. RESULTS: The ADR induced by rabies vaccine were more often seen in females aged from 1 year to 40 years. 43.59% occurred within 30 minutes after medication;94.87% manifested as allergies,and allergic shock was even noted in serious cases. CONCLUSION: Great importance should be attached to the ADR induced by rabies vaccine to ensure medication safety.

Spiritual motivation is the basic means of mental reconstruction and behavior improvement.Medical ethics education is a process that fully develop medical resources,mine the essence of western traditional thinking of medical ethics,teach the basic principles of medical ethics,and medical ethics norms,play the role of medical model,train the noble medical ethics emotion,and develop good medical ethical behaviors.Based on the present situation of medical ethics education,this article explores the features of spiritual motivation and its application.