Objective To study the clinical effect of ischemic heart valve disease combined coronary heart disease with surgical operation in the same period?Methods The clinical data of 31 cases patients of ischemic heart valve disease combined with coronary heart disease in Xinjiang Uygur Autonomous Region People′s Hospital from July 2013 to January 2015 were retrospective analyzed?According to the degree of cardiac function and symptoms,the patients toke the coronary artery bypass grafting treatment,combined with the actual operation of mitral valve replacement, mitral valve replacement, aortic valve replacement, double valve replacement at the same time?Postoperative follow?up for half year,the cardiac function of patients before and after operation were analyzed, the incidence of postoperative complications after the operation were record?Results All patients were treated by coronary artery bypass grafting, combined with the mitral valve replacement,mitral valve replacement, aortic valve replacement, double valve replacement for treatment during this period, the operations were success?There was statistically significant difference about cardiac functional grading before and after surgery ( P=0?000 )?There were 7 cases patients' left ventricular ejection ejection fraction( LVEF) was more than or equal to 40% of patients,24 cases patients'LVEF<40% before operation;21 cases patients'LVEF was more than or equal to 40%,8 cases patients'LVEF<40% after operation,the difference was statistical significance before and after the operation( P=0?000)?Only 2 patients were died because of low cardiac blood?Conclusion Non ischemic heart valve disease combined with coronary heart disease patients to take simultaneous surgical treatment, the difficulty of its operation has increased, but to strengthen myocardial protection during surgery can effectively enhance the clinical curative effect, reduce mortality, provide good protection for the survival of patients with late life.

ObjectiveTo compare the clinical efficacies of heat-sensitive point suspended moxibustion versus heat-sensitive point medicinal moxibustion in treating lumbar intervertebral disc herniation.MethodSixty patients with lumbar intervertebral disc herniation were randomly allocated to treatmentand control groups, 30 cases each. The treatment group received heat-sensitive point medicinal moxibustion and the control group, heat-sensitive point suspended moxibustion. The lumbar vertebra JOA score was recorded before and after treatment.ResultThe lumbar vertebra JOA score decreased significantly in both groups of patients after treatment (P<0.05). There was a statistically significant post-treatment difference in the lumbar vertebra JOA score between the treatment and control groups (P<0.05). There was a statistically significant difference in the total efficacy rate between the two groups (P<0.05).ConclusionThe results show that the lumbar vertebra JOA score decreased in both groups after treatment. The total efficacy rate of heat-sensitive point medicinal moxibustion is superior to that of heat-sensitive point suspended moxibustion in treating lumbar intervertebral disc herniation.

Objective To explore the role of genistein (genistcin, GEN) on human breast cancer cell proliferation and its mecha-nism. Method GEN MTT method was used to detect the proliferation of GEN on estrogen-dependent breast cancer cells MCF-7 and non-es-trogen-dependent breast cancer cell proliferation of MDA-MB231. Estrogen receptor.antagonist IC1182780 was used to observe the effect of GEN. FACS was used to analyze the cell cycle of breast cancer cells. Results GEN promote MCF-7 cell proliferation, and make G1/S transition. Estrogen receptor antagonist can block the proliferation effect on MCF-7 cells but no effect on MDA MB231. Conclusion GEN has estrogen-like activity, which was mediated by estrogen receptor (ER).

Objective To explore the clinical study of surgical treatment of the senile acute cholangitis severe type in old person.Methods According to the relationship between the senile pathophysiologic characteristics and senile acute cholangitis severe type(ACST),83 patients were selected to the study.Results In operation group with which included 83 cases,4 cases were died,the total mortality is 5.0%.Rate of remnant stone is 15.0%.Ulcer was healed in 79.0%,significantly improved in 14.0%and poor in 9.0%of patients.Conclusion When conditions turned to be stable,operation should be done in time.The main Causes of death of senile ACST are the delay of operation,severe complications and old man.

For the purpose of exploring the role of enterogenic infection in the pathogenesis of multiple system organ failure (MSOF), 40 dogs were subjected to partial occlusion of the superior mesenteric artery (SMA) for 1 hour. The results showed that ischemia and reperfusion of the intestine produced a breakdown of the intestinal mucosal barrier resulting in bacterial translocation. Subsequently, the liver, lung and cardiovascular system showed dysfunction of failure. Based on the experimental findings, it is suggested that the intestinal tract might be the target organ of reperfusion injury folowing hypovolemic shock, and it might pose as a "motor" of the development of MSOF.

Brain natriuretic peptide consists of 26 amino acids and has diuretic, natriuretic and hypotensive activities. We have synthesized BNP and its analog (BNP-A) (Mpr4, D-Ala613)-BNP(4-26)-NH2 using solid phase method and examined their biological activities. Our results showed that 1) BNP (10-7mol/L) dilated human basal cerebral artery which was pre-constricted with endothelin, 5-HT and noradrenaline in vitro; 2) both BNP (5 ?g/ rat) and BNP-A (5 ?g/ rat) increased regional cerebral blood flow following i.v. injection in rats; 3) intracerebroventricular injection of BNP (3 ?g/ rat) induced an obvious natriuretic effect when blood volume was extremely expanded with hypoosmotic glucose solution in rats; 4) BNP (5 ?g/ rat) infusion for 60 minutes caused a decline of plasma concentration of angiotensin II and aldosterone at the end of infusion in spontaneous hypertensive rats (SHR), and the bolus injection of BNP (10 ?g/ rat) led to a fall in blood pressure about 1.33kPa. We conclude that BNP is an important peptide in regulating water and sodium metabolism and plays an important role in regulating blood flow to various organs.

A series of 30 cases of traumatic posterior fossa epidural hematomas is presented. All of them were treated surgically. The mortality of 27 patients treated after the introduction of computed tomgraphy scanning was 3.7% . In view of the undecided features clinically in the early stage of trauma, in case the carualties suffered from a occipital impact with progressive headache, vomitting and deteriorative consciousness (with or without fracture in plaec), the diagnosis of the posterior fossa epidural hematoma should be considered. The authors emphasize the importance of both early diagnosis and treatment in the paper.

OBJECTIVE:To promote the international drug registration for Chinese pharmaceutical enterprises.METHODS:Based on the requirements on drug registration in Europe and the USA,we expounded the validation on analytical procedures and put forward some concrete methods.RESULT & CONCLUSION:Validation of analytical procedures plays an important role both in quality control and international drug registrations,to which Chinese enterprises should given great attention.

OBJECTIVE:To investigate the demands of medical staff for relevant medication knowledge in order to provide more targeted pharmaceutical service.METHODS:The consultation records in 2006 were collected and reviewed for an analysis in respect of classification of drugs and contents of consultation.RESULTS:Antimicrobials were most frequently consulted(27.87%).The chief contents in the drug consultation included common name and price of drugs,therapeutic regimen,dosage and administration,adverse reactions etc.CONCLUSION:Retrospective analysis of drug consultation revealed that medical staff should have the knowledge about therapeutic regimen and individuation treatment.Clinical pharmacists are expected to improve their rational drug use level by carrying out the corresponding work.

OBJECTIVE:To evaluate the efficacy of Flupentixol Melitracen for functional dyspepsia (FD) of seamen. METHODS: A total of 139 seamen with FD were enrolled,of whom,59 who had no abnormality in abnormal psychologic test were assigned to Group C,another 80 with abnormality in abnormal psychologic test were randomized to Group A or Group C. All the 3 groups received Mosapride,but Group A received additional Flupentixol Melitracen for 8 weeks. Before and after treatment,scores of gastrointestinal symptom rating scale (GSRS),self-rating anxiety scale (SAS) and self-rating depressive scale(SDS) were compared. RESULTS: The standard scores of SAS and SDS in FD seamen were higher than the domestic norms(P