Humans ; Occupational Health ; Stress, Psychological

Humans ; Occupational Exposure ; prevention & control ; Occupational Health Services ; standards

For the purpose of exploring the role of enterogenic infection in the pathogenesis of multiple system organ failure (MSOF), 40 dogs were subjected to partial occlusion of the superior mesenteric artery (SMA) for 1 hour. The results showed that ischemia and reperfusion of the intestine produced a breakdown of the intestinal mucosal barrier resulting in bacterial translocation. Subsequently, the liver, lung and cardiovascular system showed dysfunction of failure. Based on the experimental findings, it is suggested that the intestinal tract might be the target organ of reperfusion injury folowing hypovolemic shock, and it might pose as a "motor" of the development of MSOF.

Brain natriuretic peptide consists of 26 amino acids and has diuretic, natriuretic and hypotensive activities. We have synthesized BNP and its analog (BNP-A) (Mpr4, D-Ala613)-BNP(4-26)-NH2 using solid phase method and examined their biological activities. Our results showed that 1) BNP (10-7mol/L) dilated human basal cerebral artery which was pre-constricted with endothelin, 5-HT and noradrenaline in vitro; 2) both BNP (5 ?g/ rat) and BNP-A (5 ?g/ rat) increased regional cerebral blood flow following i.v. injection in rats; 3) intracerebroventricular injection of BNP (3 ?g/ rat) induced an obvious natriuretic effect when blood volume was extremely expanded with hypoosmotic glucose solution in rats; 4) BNP (5 ?g/ rat) infusion for 60 minutes caused a decline of plasma concentration of angiotensin II and aldosterone at the end of infusion in spontaneous hypertensive rats (SHR), and the bolus injection of BNP (10 ?g/ rat) led to a fall in blood pressure about 1.33kPa. We conclude that BNP is an important peptide in regulating water and sodium metabolism and plays an important role in regulating blood flow to various organs.

Burnout, Professional ; Humans

Objective To explore the feasibility and outcome of percutaneous transluminal angioplasty (PTA) as a primary treatment modality long femoro-popliteal arterial occlusions in critical limb ischemia.Methods Ten cases with 10 lesions in their femoro-popliteal arterial occlusions were treated with PTA, and the symptoms, intraoperative and postoperative DSA characteristics were retrospectively analyzed. Short-term follow-up were obtained in 8 cases. Results The technical success rate related to procedure was 90% and 12 stents were placed after PTA in femoro-popliteal arterial occlusions. One case was suffered fromamputa-lion due to development of compartment syndrome. The primary patency rate and recurrence rate of 12 months after procedure were 70% and 30% respectively. Conclusion Patients with critical limb ischemia could be beneficial from PTA in long femoro-popliteal arterial occlusions.

Objective To improve the content determination of eight-positive particles,and better control drug quality.Methods Gardenin, emodin and chrysophanol of eight-positive particles were determined by HPLC.Revised content determination standards and improved the standards of quality control. Results The revised content determinations of gardenin, emodin and chrysophanol were simple and feasible, and had high sensitivity.Conclusion Unification the quality standards of eight positive granules,the standards provide the basis for standardizing the market of eight-positive particles.

Nutritional therapy constitutes the basis for the integrated treatment of diabetes.It is essential for diabetic dietary management to be an individualized and balanced diet pattern based on total calorie control Carbohydrates is the main dietary ingredient to affect postprandial blood glucose levels.Dietary structure,way of eating,and physical exercise all contribute to the control of postprandial blood glucose levels.

Objective:To study the anatomic and CT features of the fourth and fifth tarsometatarsal joints.Methods:Thirty foot specimes taken from cadavers were randomly selected;the articular facets of the cuboid bone,fourth and fifth tarsometatarsal bones were observed and measured.As a control,thirty cases of normal adult foots underwent spiral CT(GE MEDICAL SYSTEMS Bright Speed CT16)scan with transverse and coronal and sagittal planes.With GE ADW4.2 workstations,the image data were reconstructed in 3-dimension.The structures of articular facets of the cuboid bone、fourth and fifth tarsometatarsal bones were 3D observed.After that the data were analyzed.Results:3-dimensional reconstruction spiral CT could clearly demonstrate the morphology and pattern of the articular facet of the fourth and fifth tarsometatarsal joint.Conclusion:3-dimensional reconstruction spiral CT can provide assist in diagnosis of the foot injury,especially to the guide restitution of the lateral longitudinal arcus during the operation.

Twenty-four rabbits' patellar ligaments were elongated 3 mm surgically, which decreased the pressure of the patellar articular cartilage. The pathological changes of cartilage and subchondral bone of the patellar were examined by light microscope and scanning electron microscope sequentially. 4 weeks after the surgery, proliferation of blood vessels in the subchondral bone and their invasion into the calcafied cartilage were seen, without abnormality in the patellar articular cartilage. After 8 weeks, irregularity of the tide mark and cartilage cells column, and peripheral part of the cartilage showed cluster formation. After 12 weeks, degeneration extended to the superficial layer of the cartilage, producing blister formation, fibrillation and a decrease in the thickness of the cartilage. These findings were similar to the histological changes of chondromalacia patellae. It was further suggested that decrease of pressure on the cartilage could be considered to be one of the causes for articular cartilage injury, and patella alta be correlated with chondromalacia of the patella.