The process of unfolded or misfolded proteins accumulated in the endoplasmic reticulum lumen termed endoplasmic reticulum stress (ERS), which can result in a variety of prevalent disease, such as autoimmune diseases, neurodegenerative diseases, metabolic disorders and cancer.In order to alleviate the pressure of ERS, eukaryotic cells produce a kind of adaptive intracellular signaling pathway which we called unfolded protein response (UPR, which main role is to remove misfolded proteins and restore endoplasmic reticulum homeostasis.However, apoptosis will be trigger if ERS increases continuously.There are many endoplasmic reticulum in Liver cells, the development of liver cancer is closely related to ERS and apoptosis.Therefore, finding a new method for the treatment of liver cancer in theory from the ERS induced apoptosis pathway seems so meaningful.

The highly down-loaded 175 papers from 7 journals of ophthalmology covered in Scopus database in 2011 were analyzed,showing that the most concerned subjects were rintinopathy,macular edema,glaucoma, neovasculariza-tion,Ranibizumab, retinal blood vessel obstruction, OCT,cornea, artificial lens, diabetic retinopathy, nanometer medicine and technology,the research has extended to retro-ocular segment from anterior-ocular segment,the papers of multiple authors accounted for 92%, the reviews accounted for 51.42%and were highly down-loaded.

The source indexes for the coverage of Chinese biomedical journals in MEDLINE were analyzed and compared with the mean values of those for the journals in each subject,which showed that the number of MEDLINE-covered papers published in Chinese medical journals was small ( about 260 papers each year) , the number of au-thors in each paper was 5 and the number of references in each paper was 17 with a half-life of 6. 175 years. The MEDLINE-covered Chinese medical journals did not emphasize on the publication of papers from overseas. However, it seemed that they could attract more found-supported papers.

Quality education calls for high quality teachers. The solemn mission of teachers requires them to possessgeneral inner qualities that meet the needs of the development of the era and the society. This paper first analyses thequality of the teacher from four aspects:ideal, personality, doing scholarly research and sentiment. And then analysesthe powerful educational function of the teacher's personality charm,its potential profoundness and characteristics. Thispaper uses vivid personal educational experience to illustrate the argument.

Currently, some students place more emphasis on the pursuit of their individual values, but less on their social responsibilities. This can be attributed to the students themselves and the society as well. In order to develop their sense of social responsibilities, the article suggests that we should maintain proper guidance on their values,convert our concept of intellectual fostering and direct college students to participate in social practice.

Objective To explore the clinical study of surgical treatment of the senile acute cholangitis severe type in old person.Methods According to the relationship between the senile pathophysiologic characteristics and senile acute cholangitis severe type(ACST),83 patients were selected to the study.Results In operation group with which included 83 cases,4 cases were died,the total mortality is 5.0%.Rate of remnant stone is 15.0%.Ulcer was healed in 79.0%,significantly improved in 14.0%and poor in 9.0%of patients.Conclusion When conditions turned to be stable,operation should be done in time.The main Causes of death of senile ACST are the delay of operation,severe complications and old man.

Objective To explore the characteristics of treatment of gallstone ileus.Methods According to the relationship between the senile pathophysiologic characteristics and senile acute cholangitis severe type(ACST),83 patients were selected to analyze.Results In operation group,which included 83 cases,4 cases were died,the total mortality is 5%.Rate of remnant stone is 15%.Ulcer was healed in 79%.significantly improved in 14% and poor in 9% of patients.Conclusion When conditions turned to be stable.operation should be done in time.The main causes of death of senile ACST are the delay of operation,severe complications and old man.

Objective To explore the role of genistein (genistcin, GEN) on human breast cancer cell proliferation and its mecha-nism. Method GEN MTT method was used to detect the proliferation of GEN on estrogen-dependent breast cancer cells MCF-7 and non-es-trogen-dependent breast cancer cell proliferation of MDA-MB231. Estrogen receptor.antagonist IC1182780 was used to observe the effect of GEN. FACS was used to analyze the cell cycle of breast cancer cells. Results GEN promote MCF-7 cell proliferation, and make G1/S transition. Estrogen receptor antagonist can block the proliferation effect on MCF-7 cells but no effect on MDA MB231. Conclusion GEN has estrogen-like activity, which was mediated by estrogen receptor (ER).

The clinical data was collected from 26 orthodontics patients at our hospital .All of them received straight wire appliance .The observed teeth were randomly classified into experiment and comparison groups.After the mounting of orthodontic bracket , Duraphat was smeared on the surface of maxillary central incisor, maxillary lateral incisor, maxillary canine, maxillary first premolar and maxillary first premolar in the experiment group while no Duraphat was applied in the comparison group .After wearing orthodontic appliance for 1, 3, 6 and 9 months, enamel demineralization of each tooth was observed .And the enamel decalcification index ( EDI ) of different areas of each tooth at different timepoints was recorded .More demineralization areas existed in the comparison group than the experiment group (P<0.01).In addition, no Ⅲ degree enamel demineralization was observed in the experiment group after Duraphat applying for 1 month.EDI were 0.20, 0.24, 0.21 and 0.16 in the experiment group after Duraphat applying for 1, 3, 6 and 9 months versus 0.37, 0.44, 0.44 and 0.34 in the comparison group during the same time periods.Therefore EDI and demineralization areas were significantly smaller in the experiment group than those in the comparison group (P<0.01).

Objective To Prepare and prefer method for the determination Wan Tong Yan Kang dripping pills. Methods Based on the Orthogonal test,the roundness and dissolution time were regarded as the index,the proportion of PEG4000 and PEG6000,the ratio of drug and matrix and material temperature were investigated. The pill weight pass rate (%)was regarded as the index to prepare dropping pills,the distance,dropping speed and temperature were investigated.Established isofraxidin content assay by HPLC. Results The best preparation method for drugs is:PEG4000 PEG6000 is 72,rugs:standard is1:4;the material temperature is 90 ℃;the cooling liquid temperature is 5 ℃;dropping distance is 10cm,dropping speed is 30 d/min. Isofraxidin regression equation is Y=26842X-835,R2 =0.998. Isofraxidin has good linear relationship in the range of concentrations 0.852-4.26 μg/mL. Conclusion The dripping pill preparation method is simple and feasible. Determination method has high sensitivity and good repeatability. The experiment provides a basis for the preparation of dripping pills and establishment of quality standards.