In this experimental study, Wistar rats were divided into 3 groups: Group A, 33 rats fed with diet purchased from endemic goitre area and iodine-free distilled water; Group B, 33 rats fed with the same diet of group A but 50% of casein was added and iodine-free distilled water; Group G, 33 rats fed with general rat's diet and ordinary tap water as control. After three and a half months, blood taken from ocular vein was measured for thyroid hormone and thyroid-stimulating hormone, and thyroid glands were taken for histologic examination.The results have proved that typical iodine deficient goitre and hypothyroid models have been successfully established in rats from group A and casein can prevent rats from iodine-deficient goitre and hypothyroidism. The mechanism might be that casein may enhance iodine transportation and utilization in thyroid.

Biopsy, Needle ; Breast ; pathology ; Breast Neoplasms ; diagnosis ; pathology ; therapy ; Chemotherapy, Adjuvant ; Female ; Humans ; Mastectomy ; methods ; Neoadjuvant Therapy ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Risk Factors ; Sentinel Lymph Node Biopsy

Transcatheter hepatic arterial chemoembolization (THACE)has been widely used in the treatment of advanced primary hepatic carcinoma (PHC)and metastatic hepatic carcinoma (MHC). Although the incidence of severe complications associated with THACE is unusual (0% ～ 5% ),its prognosis is generally worse and mortality is higher than that of postembolization syndrome.Therefore,to minimize the risk associated with THACE has to be achieved through the understanding of these severe complications related to the selection of indication,the use of chemoembolic agents and manipulation of a cathether or guide wire,etc. In this paper,according to the involved anatomic organs,these severe complications are divided into six categories as follows:(1)complications of the liver,including acute hepatic failure,liver infarction (necrosis),liver abcess and liver (or tumor)ruptrure;(2)complications of the celiac artery and its branches,included of iatrogenic dissection,stricture or occlusion,perforation or pseudoaneurysm and multiple intrahepatic aneurysms; (3)complications of intrahepatic biliary system,included of cholecystitis and gallbladder infarction,bile duct necrosis and intrahepatic biloma formation; (4)complications of extrahepatic structures,included of nontarget embolism or infarction of the brain,spinal cord,lung,spleen,gastroduodenum and pancreas; (5)bleeding of upper digestive tract; (6)the orthers. And the incidence,pathogenesis,predisposing factors,clinical and imaging manifestations of these complications are also discussed in detail,it may be of great advantage to its correct diagnosis promptly and appropriate management.

Current goals of ulcerative colitis treatment include rapid remission,steroid-sparing remission,endoscopic mucosal healing,reduction in hospitalization and surgery and improvement in quality of life.The treatment principle is rational medications according to the severity,activity and extent of the disease with individualized and comprehensive treatment.The medications conventionally used are 5-ASA,GCS and IS.Newly developed biological agents like Anti TNF-?(infliximab)are used in severe UC and refractory cases.Traditional Chinese Medicines have been used in more than 80% of UC cases and will play a great role in the future.The indications for surgery include acute perforation,massive hemorrhage,toxic megacolon,malignancy and refractory cases for medical therapy.

We find that K+-pNPPase from brain of rats is inhibited by the urine of patients with hepatitis, and of the control, desalted through a sephadex G-23 colum n.the percentage of inhibition showed as I%[I%=(1-Vi/Vo)?100%] was 59.9 ? 8.9 (n= 9) from patients with fulminant hepaticfailure (If), and was 84.1 ? 9.4 (n = 10) from chronic active hepatitic patients (Ic), The control (In) was 70.6?15,2 (n=13).It showed that the inhibition of FHF urine was less marked than that of CAH.P

Objective:To assess the feasibility of dilute sulfuric acid injected into the rabbit liver in vivo,and to provide experimental proof for the interventional therapy on hepatocellular carcinoma.Methods:10 big white rabbits were randomly divided into two groups.10% sulfuric acid was injected into liver at a dose of 1ml.In the first group,the biochemical changes in serum were examined before and immediately,3,7,and 15 days after the procedure.In the second group,histopathological findings of the liver were observed after 10% sulfuric acid injected into liver immediately,3,7,15 and 30days postoperatively.Results:The ALT and AST level in serum had transient elevation,but shortly returned to the same level as before the procedure.There was no significant elevation of ALB,ALP,?-GGT,TBIL,DBIL and BUN level after the procedure.Pathological changes indicated hepatocellular degeneration,coagulative necrosis,inflammatory cells infiltration and granulation tissue proliferation.Conclusion:Diluted sulfuric acid have strong power of cells inactivation,but without obvious toxicity and side-effect,which could be a new type of tumor cells inactivation material for the treatment of hepatocellular carcinoma local ablation.

The ability to construct knowledge from data is displayed more significantly in data literacy than that of traditional information literacy.The connotation of medical data education was summarized,the current situation of domestic and foreign medical data literacy education was reviewed,and the necessity of data literacy education in medical colleges and universities was analyzed,with suggestions put forward for the target of data literacy teaching,allocation of teaching resources,and design of teaching.

OBJECTIVE:To analyze the postoperative application of anti-infective agents in patients undergoing stem cell transplantation. METHODS:The application of anti-infective agents in 30 patients undergoing stem cell transplantation in the pretreatment period and after operation in our hospital from 2003 to 2008 were analyzed in respect of etiology inspection,the cost of anti-infective agents,utilization frequency(cases/times),duration of medication,DDDs,DUI,drug combination and its rationality. RESULTS:The infection was found in 26 cases after operation,accounting for 86.67%. Pathogens were found out in 11 cases. The total cost of anti-infective agents was 327 598.23 yuan. The DUI of 7 kinds of top 10 anti-infective agents in terms of DDDs were less than 1 and that of other 3 were more than 1. In terms of drug combination,two-drug consisted of 73.08%(38 cases/times), three-drug 25.00%(13 cases/times)and four-drug 1.92%(1 cases/times). CONCLUSION:The postoperative application of anti-infective agents in patients undergoing stem cell transplantation in our hospital is rational on the whole.

Blood viscosity, plasma viscosity, haematocrit and electrophoresis time of red blood cell and platelet were raeasured before and 24h after operation, in which 8 rabbits were AMI, and 8 with the coronary arteria not ligated as control. The AMI group had significantly higher adjusted viscosity and electrophoresis time of red cell and platelet than the control group (P

There were increasing studies on the association of periodontal diseases with coronary heat disease (CHD) in the recent 20 years. This article reviewed the evidence supporting the association between periodontal disease and CHD, the possible mechanisms explaining the association, and the possible effect of periodontal treatment on the risk of CHD. In general, it is suggested that periodontal disease especially periodontitis is modestly associated with CHD. Besides there are some common risk factors, such as smoking, stress, elder age, male gender and low socioeconomic status, between these two diseases, long chronic periodontal infections by periodontal pathogens, the systemic acute-phase response and host immuno-inflammatory response to the exposures of periodontal infection appear to be the important mechanisms for connecting the periodontal disease and CHD. Periodontal treatment can decrease the infection of periodontal pathogens and therefore, reduce the systemic inflammatory burden. It was observed in some studies that periodontal treatment could reduce the serum inflammatory biomarkers such as C-reactive protein and improve endothelial function. Even though the studies on effect of periodontal interfere on CHD are still limited now, it appears hopeful that periodontal treatment could reduce the risk of CHD and therefore become one of the preventing strategies for CHD.