In this experimental study, Wistar rats were divided into 3 groups: Group A, 33 rats fed with diet purchased from endemic goitre area and iodine-free distilled water; Group B, 33 rats fed with the same diet of group A but 50% of casein was added and iodine-free distilled water; Group G, 33 rats fed with general rat's diet and ordinary tap water as control. After three and a half months, blood taken from ocular vein was measured for thyroid hormone and thyroid-stimulating hormone, and thyroid glands were taken for histologic examination.The results have proved that typical iodine deficient goitre and hypothyroid models have been successfully established in rats from group A and casein can prevent rats from iodine-deficient goitre and hypothyroidism. The mechanism might be that casein may enhance iodine transportation and utilization in thyroid.

Biopsy, Needle ; Breast ; pathology ; Breast Neoplasms ; diagnosis ; pathology ; therapy ; Chemotherapy, Adjuvant ; Female ; Humans ; Mastectomy ; methods ; Neoadjuvant Therapy ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Risk Factors ; Sentinel Lymph Node Biopsy

OBJECTIVE:To explore the contents of synephrine in raw Fructus Aurantii Immaturus and its processed products.METHODS:HPLC was used for the quantitative analysis of raw Fructus Aurantii Immaturus and its processed products;C 18 was used as the Chromatographic column;methanol-water(43∶57)which contained0.1%phosphoric acid and0.1%soldium dodecyl sulfonate was used as the mobile phase with a detected wavelength at275nm,column temperature at40℃and a flow speed at1.0ml/min.RESULTS:Synephrine contents of the vinegar-fried product was the highest and that of the alcohol-fried product was the lowest.CONCLUSION:There is a significant difference in intrinsic quality among various processed products of Fructus Aurantii Immaturus.

Objective To investigate the clinical characteristics of severe cerebrovascular disease complicated with lung injury.Methods The clinical data of 46 cases of severe cerebrovascular disease were retrospectively analyzed.The cause,risk factors,clinical manifestations of lung injury were also analyzed.Results In 46 cases of severe cerebrovascular disease,33 cases [71.7％(33/46)] occured lung injury,including 28 cases of lung infection,3 cases of neurogenic lung edema,2 cases of lung embolism.Great age,disturbance of consciousness,swallowing disorders,bed time were the important risk factors for lung injury (P ＜ 0.05).Conclusions Lung injury is a common complication of severe cerebrovascular disease.Early assessment,early prevention and early diagnosis and treatment are the keys for reducing its incidence.

Fifty cases of HCC with 105 procedures of TAI/TAE performed by DSA system were analysed retrospectively.Improperly operative technique used in the procedure of TAI/TAE was found in sixteen cases of this series,included:unsuccessfully superselec- tive catheterization of the hepatic artery in 6 cases,resulting from the unskillful catheteriza- tion or the abnormality of target arteries,etc.Failure recatheterizations of the hepatic arter- ies in the initial or subsequent procedures of TAI/TAE were occurred in the other 6 cases. (because of the stenosis/obstruction of hepatic artery resulted from the intimal injury of the target artery by repeated catheterization,the infusion of anticancer drugs(MMC,5-Fu)and excessive embolization of hepatic artery with gelatine sponge,ete);In the remaining 4 cas- es,the tumor's parasitic vessels-inferior phrenic arterier were neglected due to no abdominal aortography was performed.The results of 16 cases with improperly operative technique of TAI/TAE showed that the decrease of tumor's size was frequently less than 50 per cent,or no change,and in few cases the size of tumor became larger than before.Comparing the de- crease rate of tumor in this 16 cases with the comparative group also confirmed the presence of the significant difference(P

Object To study the chemical constituents in Ligustrum sinense Lour.Methods One new and four known phenolic glycosides were isolated and identified by column chromatography, MS, IR and NMR data.Results Five phenolic and two lignan components were isolated from water soluble part in methanol extract of the stem and leaves of L.sinense.The obtained compounds were identified as sinenosides I, 8′-?-hydroxyl-lariciresinol-4′-O-?-L-glucopyranoside (Ⅰ), a new compound; liriodendrin (Ⅱ); kaempferol-3-O-?-D-glucopyranoside (Ⅲ); 7-O-?-L-rhamnopyransyl-kaempeferol-3-O-?-D-glucopyranoside (Ⅳ), 7-O-?-D-rhamnopyransyl-kaempeferol-3-O-?-D-rhamnopyranoside (Ⅴ).Conclusion All the compounds were isolated from this plant for the first time.

Objective:To assess the feasibility of dilute sulfuric acid injected into the rabbit liver in vivo,and to provide experimental proof for the interventional therapy on hepatocellular carcinoma.Methods:10 big white rabbits were randomly divided into two groups.10% sulfuric acid was injected into liver at a dose of 1ml.In the first group,the biochemical changes in serum were examined before and immediately,3,7,and 15 days after the procedure.In the second group,histopathological findings of the liver were observed after 10% sulfuric acid injected into liver immediately,3,7,15 and 30days postoperatively.Results:The ALT and AST level in serum had transient elevation,but shortly returned to the same level as before the procedure.There was no significant elevation of ALB,ALP,?-GGT,TBIL,DBIL and BUN level after the procedure.Pathological changes indicated hepatocellular degeneration,coagulative necrosis,inflammatory cells infiltration and granulation tissue proliferation.Conclusion:Diluted sulfuric acid have strong power of cells inactivation,but without obvious toxicity and side-effect,which could be a new type of tumor cells inactivation material for the treatment of hepatocellular carcinoma local ablation.

Germinal center is a site of B cell maturation and development, in which B cell activation and differentiation was regulated by inherent complexity signal and transcription factors networks. Under the normal condition, the interaction between these transcription factors maintain dynamic stability of B cell in germinal center. When cytogenetic abnormalities or viral infection appear, a variety of.abnormal expression of transcription factors induced the imbalance of B cell signal networks regulation. manifested as abnormal B cell proliferation, apoptosis, and differentiation was blocked. B cell malignancies were often associated with genetic change of B cell and abnormal expression of transcription factors.

Objective To analyze the pathogens and drug resistance of patients with chronic obstructive pulmonary disease and community-acquired pneumonia,in order to provide the evidence for rational drug use in the future.Methods The sputum specimens of 60 patients with chronic obstructive pulmonary disease and communityacquired pneumonia were detected for pathogens and drug sensitivity.Results 24 patients were infected with pathogens Streptococcus pneumoniae(40％).8 cases were infected with Haemophilus influenza(16.7％).10 patients were infected with Klebsiella pneumonia (13.3％).6 patients were infected with Mycoplasma lung (8.3％).5 patients were infected with alpha-hemolytic streptococcus (6.7％).4 patients were infected with Staphylococcus aureus (3.3％).Two patients were infected with Legionella pneumophila (3.3％).Unknown pathogen was one case (1.67％).Drug sensitive test showed that gram-negative bacteria had high resistance rate.Haemophilus influenzae,Streptococcus pneumonia and Legionella pneumophila had high resistance rate against penicillin.Mycoplasma lung and Klebsiella pneumoniae showed resistance to azithromycin.Staphylococcus aureus and hemolytic streptococcus showed resistance to Cefalotin.Conclusion The patients with chronic obstructive pulmonary disease and community-acquired pneumonia were mainly infected gram-negative bacteria,which had serious antibiotic-resistant.We should choose other drugs according to the results of drug sensitive test in the future,so as to improve the anti-bacteria effect and protect the health of patients.

Blood viscosity, plasma viscosity, haematocrit and electrophoresis time of red blood cell and platelet were raeasured before and 24h after operation, in which 8 rabbits were AMI, and 8 with the coronary arteria not ligated as control. The AMI group had significantly higher adjusted viscosity and electrophoresis time of red cell and platelet than the control group (P