In this experimental study, Wistar rats were divided into 3 groups: Group A, 33 rats fed with diet purchased from endemic goitre area and iodine-free distilled water; Group B, 33 rats fed with the same diet of group A but 50% of casein was added and iodine-free distilled water; Group G, 33 rats fed with general rat's diet and ordinary tap water as control. After three and a half months, blood taken from ocular vein was measured for thyroid hormone and thyroid-stimulating hormone, and thyroid glands were taken for histologic examination.The results have proved that typical iodine deficient goitre and hypothyroid models have been successfully established in rats from group A and casein can prevent rats from iodine-deficient goitre and hypothyroidism. The mechanism might be that casein may enhance iodine transportation and utilization in thyroid.

Objective To analyze the pathogens and drug resistance of patients with chronic obstructive pulmonary disease and community-acquired pneumonia,in order to provide the evidence for rational drug use in the future.Methods The sputum specimens of 60 patients with chronic obstructive pulmonary disease and communityacquired pneumonia were detected for pathogens and drug sensitivity.Results 24 patients were infected with pathogens Streptococcus pneumoniae(40％).8 cases were infected with Haemophilus influenza(16.7％).10 patients were infected with Klebsiella pneumonia (13.3％).6 patients were infected with Mycoplasma lung (8.3％).5 patients were infected with alpha-hemolytic streptococcus (6.7％).4 patients were infected with Staphylococcus aureus (3.3％).Two patients were infected with Legionella pneumophila (3.3％).Unknown pathogen was one case (1.67％).Drug sensitive test showed that gram-negative bacteria had high resistance rate.Haemophilus influenzae,Streptococcus pneumonia and Legionella pneumophila had high resistance rate against penicillin.Mycoplasma lung and Klebsiella pneumoniae showed resistance to azithromycin.Staphylococcus aureus and hemolytic streptococcus showed resistance to Cefalotin.Conclusion The patients with chronic obstructive pulmonary disease and community-acquired pneumonia were mainly infected gram-negative bacteria,which had serious antibiotic-resistant.We should choose other drugs according to the results of drug sensitive test in the future,so as to improve the anti-bacteria effect and protect the health of patients.

The ability to construct knowledge from data is displayed more significantly in data literacy than that of traditional information literacy.The connotation of medical data education was summarized,the current situation of domestic and foreign medical data literacy education was reviewed,and the necessity of data literacy education in medical colleges and universities was analyzed,with suggestions put forward for the target of data literacy teaching,allocation of teaching resources,and design of teaching.

Biopsy, Needle ; Breast ; pathology ; Breast Neoplasms ; diagnosis ; pathology ; therapy ; Chemotherapy, Adjuvant ; Female ; Humans ; Mastectomy ; methods ; Neoadjuvant Therapy ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Risk Factors ; Sentinel Lymph Node Biopsy

Objective:To explore the chemical and biological assay pattern for the quality control and evaluation of Chinese mate-ria medica solid preparations ( CMMSP) . Methods:Compound berberine tablets were used as the model drug, the inhibition against sensitive strains of the dissolution solution at different time points was studied with water as the dissolution medium, and the cumulative dissolution of compound berberine tablets was obtained based on the bacterial inhibitory rate. The dissolution of hydrochloric acid ber-berine was also determined by HPLC, and a f2 similar factor method was used to evaluate the relevance of the two methods. Results:The antimicrobial test showed that berberine was sensitive to escherichia coli,staphylococcus aureus, bacillus subtilis, micrococcus luteus and candida albicans etc, and among them, the antibacterial circle edge of bacillus subtilis was clear with higher sensitivity. The disso-lution curve of compound berberine tablets determined by HPLC as the reference, the similarity factor f2 of bio-dissolution curve of com-pound berberine tablets from 7 different manufactures was greater than 50, which suggested that the dissolution determination method based on biological titer determination could comprehensively reflect the bioavailability of compound berberine tablets. Conclusion:The biological activity evaluation method for dissolution is expected to be one of the effective means for in vitro dissolution test of CMMSP.

Blood viscosity, plasma viscosity, haematocrit and electrophoresis time of red blood cell and platelet were raeasured before and 24h after operation, in which 8 rabbits were AMI, and 8 with the coronary arteria not ligated as control. The AMI group had significantly higher adjusted viscosity and electrophoresis time of red cell and platelet than the control group (P

Objective To investigate the clinical characteristics of severe cerebrovascular disease complicated with lung injury.Methods The clinical data of 46 cases of severe cerebrovascular disease were retrospectively analyzed.The cause,risk factors,clinical manifestations of lung injury were also analyzed.Results In 46 cases of severe cerebrovascular disease,33 cases [71.7％(33/46)] occured lung injury,including 28 cases of lung infection,3 cases of neurogenic lung edema,2 cases of lung embolism.Great age,disturbance of consciousness,swallowing disorders,bed time were the important risk factors for lung injury (P ＜ 0.05).Conclusions Lung injury is a common complication of severe cerebrovascular disease.Early assessment,early prevention and early diagnosis and treatment are the keys for reducing its incidence.

Germinal center is a site of B cell maturation and development, in which B cell activation and differentiation was regulated by inherent complexity signal and transcription factors networks. Under the normal condition, the interaction between these transcription factors maintain dynamic stability of B cell in germinal center. When cytogenetic abnormalities or viral infection appear, a variety of.abnormal expression of transcription factors induced the imbalance of B cell signal networks regulation. manifested as abnormal B cell proliferation, apoptosis, and differentiation was blocked. B cell malignancies were often associated with genetic change of B cell and abnormal expression of transcription factors.

The diagnosis of the rupture of the fibular collateral ligament of the ankle following varus injury can be made by inversion test film and anterior drawer test which s similar to the examination of the instability of the anterior cruciate ligament at at the knee.In order to evaluate the value of the anterior drawer test for the diagnosis of this lesion, the radiological evidences of the anterior and varus stress viewa were observed by dividing different fasciulus of the lateral ligament in 21 fresh cadaveric and amputated ankles.The effects of the applied weight and plantar flexion and the muscular tension of the lower leg on the antrior Subluxation of the talus i.e. positve anterior drawer sign were investigated.The clinical assessments were then made in 20 injuried ankles of 20 patients who were suffered from varus sprains.All injuried ankles of these patients were treated by surgery and the ligmentous injuries were verified. Then a comparision was made between the two stress views obtained before operation. The positive anterior drawer sign was demonstrated to be more common than varus tilt of the talus.Therefore, it is suggested that the antrior drawer test is very valuble in the diagnosis of the rupture of the anterior talofibular ligament.In this article the various factors which influenced the measured value of the anterior drawer test were discussed and the method of the examination and the diagnostic criteria were proposed.

Microbiological assay of the essential amino acids was carried out on a 10% protein diet containing 80% rice and 6% soybean meal. The most limitng essential amino acid according to the value recommended by Rose was found to be methionine(0.09%), the second was lysine(0.29%), and the third histidine(0.23%).The animal experiment consisted of 2 parts. In the first the effect of adding 0.3, 0.6, 0.9 and 1.8g% of DL-methionine to the basal diet was observed upon the growth of weanling albino rats for a two-week period.Results revealed that supplementation of methionine at all level tended to dep- ress growth of rats, especially at the 1.8% level, i.e. an average of 7g gain per two weeks compared with 29g of control group when no methionine was added.In the second part the effect of supplementing lysine or histidine to the level recommended by Rose, or adding pyridoxine was studied on the growth depression, caused by methionine excess in the diet of rats. Lysine improved food consumption and weight gain, showing an average of 23.5g for the two-week period, while it was 17.5g on the methionine excess diet. However, it did not reach the 35g of the basal diet group Both histidine and pyridoxine did not have any effect, the liver weight changes of rats were related to their body weight changes. No significant differences in liver nitrogen, liver water content and concentration of hemoglobin among the different groups were found.