Studying on typhoid fever in 16417 people of Binh Thanh Trung commune and 16324 ones of Vinh Thanh commune (control commune) after 2 years with the intervention. The results showed that drinking water sterilized by chloramin B increased by 295.58%, drinking boiling water increased by 10.06%; drinking rainny water increased by 464.30%; vegetable washing by safety water increased by 2886.61%, good sanitary latrine increased by 292.30%, close fish pond latrine increased by 46.91%, sinking latrine increased by 195.995%, fish pond latrine open to river reduced by 17.68%, latrine on the river reduced by 29.24%. Typhoid fever reduced by 92% in comparison to before interventrion. Real effect in comparison to control commune was 5.04%
Typhoid Fever ; Therapeutics ; Epidemiology

Morbidity and mortality of typhoid fever in Dong Thap province had reduced gradually in the last 10 years. The number of typhoid fever between 1999 and 2003 was equal to a third cases occurred between 1994 and 1998. There had been 29 of dead cases resulting from typhoid fever for ten years. The highest number of dead cases in 1995 was 6. The death to incidence ratio was 0.076%
epidemiology ; Typhoid Fever ; Fever

There were 89 patients, no death in an outbreak of cholera in Dong Thap province, which happened on January 1st 1999 and lasted for 2 months. The morbidity was 5,61/100.000 inhabitants with all ages; the disease occurred at districts, towns along the Cuu Long river. Local authorities had conducted measures for cholera prevention and control.
Cholera ; Disease Outbreaks

Background: Gougerot-Sj\xf6gren syndrome is an autoimmune disorder with two remarkable symptoms such as dry eyes and dry mouth. Objective: To study the symptoms of dry mouth of Gougerot-Sj\xf6gren syndrome after rheumatoid arthritis; To evaluate clinical and subclinical manifestations of dry mouth. Subjects and method: A prospective, descriptive, cross-sectional study included 160 patients with rheumatoid arthritis, who treated at Department of Rheumatology of Bach Mai hospital, from 1998 to 2003. The patients were divided into 2 groups: 60 patients with Gougerot-Sj\xf6gren syndrome and 100 patients without Gougerot-Sj\xf6gren syndrome. Results: The average age of patients with Gougerot-Sj\xf6gren syndrome was 54.55 \xb1 10.91 years. The mean time of having dry mouth was 8.65 \xb1 8.39 months. Clinical manifestations of dry mouth were sensation of dry mouth (90%), lost of saliva (80%), drink a lot of water while eating (58.3%), enlargement of parotid glands (15%). Degrees of dry mouth were mild and moderate (36.7%), severe (53.3%). 93.3% of patients decreased total salivary flow.82% of patients had 3 and 4 anatomopathologic stages according to Chilsom classification. Conclusion: Incidence of symptoms of dry mouth was higher significantly in the rheumatoid arthritis patients with Gougerot-Sj\xf6gren syndrome than those without Gougerot-Sj\xf6gren syndrome.
Arthritis ; Rheumatoid/ pathology ; diagnosis ; Sjogren's Syndrome/ pathology ; diagnosis ; Xerostomia/ pathology ; diagnosis

Background: Tophi is an important symptom of chronic gout. Objective: To assess clinical characteristics of topbi and its relationships with other manifestations of chronic gout. Subjects and method: A study was conducted in 65 patients diagnosed chronic gout based on Bennett and Wood criteria 1968, with tophi, treated at Department of Rheumatology, Bach Mai hospital, from December 2003 to June 2004. This was a retrospective, prospective, cross-sectional study. Results and conclusions: All patients were males and the average age was 57.8 \xb1 11.71 years. 72.3% of patients aged from 30 to 59 years. The average time of occurrence of tophi in chronic gout was 7.73 years. The mean number of tophi was 24.8 \xb1 9.4 (ranged from 1 to 70). Erosion of tophi occurred 25%. 92.9% of patients had distribution in inferiors limbs and 80.4% had superior limbs. There were relationships between number of tophi and renal lesions, distribution of tophi and number of painful joints.
Gout/ pathology ; therapy

Effects of artesunate in the combination of other antimalarial drugs (primaquine, mefloquine or chloroquine) on activities of some murine plasma enzymes were studied: (1) The combination of artesunate with primaquine induced significantly plasma activities of GOT, GPT, LDH, - HBDH, CK and CK- MB in comparison with artesunate alone; (2) The combination of artesunate with mefloquine also induced significantly plasma activities of GOT, GPT, LDH, -HBDH, CK and CK- MB in comparison with artesunate alone; (3) The companation of artesunate with chloroquine reduced slightly plasma activities of GOT, GPT, LDH, -HBDH, CK and CK-MB. The results obtained in the study suggest that the combination of artesunate with primaquine or mefloquine on murine cellular damage is synergistic, while the combination of artesunate with chloroquine is probably antagonistic
Malaria ; artesunate ; drug therapy ; therapeutics ; Pharmaceutical Preparations

The streptozotocin - induced diabetic mice (STZ 300mg/kg/ip), either the methanol extract of rhizomes of Smilax glabra Roxb. - Smilacaceae (SG) or the tolbutamid did not effect the blood sugar, one of the model of insulin - dependent diabetes mellitus (IDDM) with hypoinsulinemia. However, while tolbutamid coundn't decrease epinephrine - induced hyperglycemia in mice. SG suppressed partially this one. The result, suggested that SG reduced the blood sugar by an extra - pancreas mechanism
Plants, Medicinal ; Hypoglycemic Agents

The methanol extract of rhizomes of smilax glabra Roxb. Smilacaceae reduced the blood glucose of normal mice. The maximal hypoglycemic effect was about 38% at the dose of 100mg/kg body weight per intraperitoneal route, and about 56% with 200 mg/kg/ip. The oral administration of 200 mg/kg body weight did not decrease yet the blood glucose. The LD50 per intraperitoneal route in mice was 2500 mg/kg body weight
Hypoglycemic Agents ; Mice

The methanol extract from rhizomes of Smilax glabra Roxb - Smilacaceae reduced the blood glucose of normal mice. The maximal hypoglycemic effect was about 36% with the dose of 100mg/kg-body weight per intraperitoneal route, and about 56% with 200 mg/kg/ip. The oral administration of 200 mg/kg body weight doesn't decrease yet the blood glucose. The LD50 per oral route in mice is 2500 mg/kg body weight
Hypoglycemic Agents ; Mice

The hypoglycemic effect of rhizomes of SG was investigated in the previous publication in normal mice. This study attempts to explain its mechanism of action. The streptozotocin-induced diabetic mice (STZ 300 mg/kg/ip) one of the model of insulin-dependent diabetes mellitus (IDDM) with hypoinsulinemia, either the methanol extract of rhizomes of SG Roxb - Smilacaceae or the tolbutamid did not affect the blood sugar. However, while tolbutamid couldn't decrease epinephrine - induced hyperglycemia in mice, SG partially suppressed this one. From these results, it is suggested that SG reduce the blood sugar by an extra - pancreas mechanism
Hypoglycemic Agents ; Mice