Breast Neoplasms ; etiology ; genetics ; pathology ; Chromosome Aberrations ; Comparative Genomic Hybridization ; Epithelial Cells ; pathology ; Female ; Fibroadenoma ; genetics ; Humans ; Loss of Heterozygosity ; Phyllodes Tumor ; etiology ; genetics ; pathology ; Stromal Cells ; pathology

Animals ; Humans ; Learning ; drug effects ; Memory ; drug effects ; Metals ; toxicity ; Nervous System ; drug effects

A drill protector which can lock the drilling depth was designed, which is easy and safe.
Equipment Design ; Fracture Fixation ; instrumentation ; Surgical Instruments

Objective To check the change of endothlins-1(ET-1) and CGRP in the patients with asthma bronchitis.Methods 45 cases of the treatment group and 15 cases of the routine group were detected by radioimmunossay(RIA).Results The contents of ET-1 and CGRP before treatment with dopamine(DP),dobutamine(DOB) and hentolamine(PTL) group were (117.6?7.5)ng/L,(102.1?12.3)ng/L;(112.4?6.5)ng/L,(104.1?10.3)ng/L;(120.6?6.5)ng/L,(99.1?9.3)ng/L,respectively;It was obviously higher than after treatment (69.9?8.6)ng/L,(72.8?17.1)ng/L;(56.9?8.0)ng/L,(68.8?16.1)ng/L;(72.0?9.0)ng/L,(67.8?15.3)ng/L(P

Objective:To investigate the feasibility,safety and superiority of transvagina endo- scopic cholecystectomy used in clinical application.Methods:31 patients with gall-bladder diseases were treated in transvagina endoscopic cholecystectomy.Through a 5mm cut below the umbilicus, inserted laparoscopic guide gastroscope and NOTES manipulator enter abdominal cavity through posterior fornix 15mm cut.After the gastroscope can capture stable vision,withdraw the laparoscope and insert normal laparoscopic manipulator.With the gastroscope monitoring,accomplish cholecystectomy using umbilical and pudendum manipulator.Results:All of patients were accepted this new type operation.The operation time was 60～150 minutes,and the average time was 85 minutes.No postoperative draining,bleeding and biliary fistula occurred in those patients. There was no obvious scar in belly,and all of patients felt no pains after operation.The average inpatient time was shorten,the medical cost decreased.Conclusion:Transvagina endoscopic cholecystectomy is feasible and safety.Comparing to traditional laparoscopic operation,it has obviously superiority.Transvagina endoscopic cholecystectomy should be widely applied in good condition hospitals.

Objective:To study the protective effect of self-designed Shanghai multi-organ preservation solution(SMO) on mitochondria function in canine kidney cortex during cold storage.Methods: Canine kidneys were perfused and stored with cold(0-4℃) SMO,HC-A and UW solution (the later 2 as control) separately.Ultrastructure alteration of mitochondria was observed by electron microscopy.Mitochondria were isolated from cortex homogenization by differential centrifugation and their respiratory function was measured polarographically with Clark oxygen electrode.The four-state curve of mitochondria respiration was drawn and the state Ⅲ and Ⅳ oxygen consumption rate,the respiration control proportion(RCR) and phosphatasel/oxygen ratio(P/O) were calculated.Results: We found that the mitochondria swelling and membrane disruption in HC-A group were more severe than those in SMO and UW group.The rate of oxygen consumption in state Ⅲ,RCR and P/O were obviously decreased in all groups with the prolongation of cold storage time.The rate of oxygen consumption in state Ⅲ in HC-A group was lower compared to that in SMO group during 1-3 d cold storage(P

Currently, the widespread use of new media challenges ideological and political education among the medical students. The study explores the effects on medical students' values by new media on the basis of analyzing its characteristics, including communication space, information, subject and route. In addition, the study analyzes the mode's theoretical construction and practical op-eration from these aspects:the mode's connotation, operation mechanism, the characteristics and prac-tical application.

Natural killer (NK) cells,a major cell type of the innate immunity,have a central role in infections,immunizations and tumors.The relationship between NK cells and hematological malignancies is increasingly pursued by domestic and foreign researchers.Exploring the relationship between function and activity of NK cells and malignant hematological disease is of great importance.

Mantal cell lymphoma (MCL) is a rare and special type of non-Hodgkin lymphoma.MCL is classified as an aggressive variety of lymphoma and yet it sometimes behaves as an indolent lymphoma.Although the first-line therapy of MCL is highly effective,but it is incurable through conventional chemotherapy.Patients with MCL have a poor prognosis.This review focus on a new therapeutic approach,mammalian target of rapamycin (mTOR) inhibitor.Temsirolimus,a derivation of rapamycin,in MCL cell lines inhibited mTOR.Temsirolimus could inhibits tumor cell proliferation through cell cycle arrest and able to down-regulation of cyclin D1 and Ki-67 in lymphomacell.Clinical trials showed that temsirolimus induced patients with MCL response rate and a prolong progression-free survival.In addition,preclinical studies demonstrated the use of a combination of temsirolimus with monoclonal antibodies or conventional chemotherapy to improve the efficacy of single agent use.Altogether,temsirolimus shows promising results in the therapy of patients with heavily MCL,and especially responses in chemotherapy refractory patients,providing a novel approaches to treatment of MCL.

Objective To investigate the clinical features of uterine empyema complicated with perforation of the uterus,the causes of misdiagnosis and measures of reducing misdiagnosis.Methods Twenty clinical cases from 2008 to 2013 in the First People's Hospiptal of Shangqiu were treated postmenopausal,uterine empyema and uterine perforation,and 16 cases of whose first diagnosed leak or misdiagnosed patients were retrospectively analyzed.Summarize the clinical characteristics,misdiagnosis and experiences in order to reduce the misdiagnosis of the disease.Results Among 20 cases of uterine perforation and Uterine empyema,16 cases first diagnosed misdiagnosed,and the incidence was 80％ (16/20).One case was diagnosed tumor torsion,1 case of diagnosis of pelvic abscess,14 cases first diagnosed of surgery (8 cases of acute peritonitis,gastrointestinal perforation in 4 cases and 2 cases of perforated appendicitis).It all occurred in postmenopausal women,and the main clinical features were that:high fever,lower abdominal pain,feel bloated in the rectal,mass pelvic cavity,weakened movement of intestine and cervical disturbance pain.results of emoyemic bacteria culture were mainly colon bacillus (E.coli).The main causes of misdiagnosis were atypical clinical manifestations,clinicians lack of comprehensive analysis and dynamic observation of the disease,over-reliance on laboratory examinations;their performance was often the first diagnosis of acute abdomen surgery,the surgeon only undergraduate examination,as well as undergraduate diagnosis of inertia thinking,neglect gynecological examination.All patients had a one-time cure after surgery.Conclusion Uterine empyema complicated with uterine perforation occurs mainly in postmenopausal women,which had a higher rate of misdiagnosis.Correctly diagnosis and timely treatments make benefits to the prognosis.