ObjectiveTo explore the diagnosis value of color Doppler ultrasound of the carotid atherosclerosis plaques in diabetic patients. MethodsColor Doppler ultrasonic assessment of carotid was performed in 124 diabetic patients(test group)and 100 normal controls(control group).The intima-media thickness(IMT)and the carotid atherosclerosis plaques parameters were measured.The results were compared and analyzed between two groups. ResultsThe IMT and the incidence rate of carotid atherosclerosis plaques in the test group were higher than those in the control group(all P＜0.05).There was no statistical difference in the site of the plaques between test and control group(P＞0.05). ConclusionThe incidence rate of the carotid atherosclerosis of type 2 diabetes was higher.Carotid color Doppler ultrasonography was an optimal technique for screening and diagnosing atherosclerosis.

Objective To explore the clinical efficacy of percutaneous vertebroplasty technique(PVP) in the patients with senile osteoporotic thoracolumbar compression fractures (OVCFs) and to explore the main factors of PVP.Methods PVP treatment of OVCFs 46 cases,in the perspective of C-arm X-ray,bone cement as a filling material,transpedicular puncture and injection of 59 vertebrae.Results The pain in 35 cases(76.09％) OVCFs patients apparent ease or disappear,the remaining 11 cases of moderate relief;follow-up period(3 to 15)months(mean 8.6months).After X-ray review,the patient' s bone cement dispersion was good and has improved vertebral height has not been lost,activity and quality of life significantly inproved.Conclusion PVP is simple,less invasive,etc.,which can quickly reduce pain and improve their quality of life.

Frequently,there is a lack of safety data about diagnostic method and drug therapy of digestive diseases during pregnancy. It is profitable to understand the limited evidences of safety data about diagnosis and drug therapy of digestive diseases during pregnancy,which will allow the accurate evaluation and risk assessment on diagnostic method and treatment during pregnancy. High-quality clinical study on patients with pregnancy is helpful for the management of common digestive diseases among this special population.

Objective To explore the mutual relationship of cognitive behavioral intervention and negative emotion of leukaemia patients. Methods According to hospital dual order, 120 patients were divided into the treatment group and the control group with 60 cases in each group, the control adopted routine treatment and nursing, upon this basis, the treatment group received cognitive behavioral intervention.Anxiety and depression of two groups were compared with SAS and SDS scale. Results SAS and SDS score changed significantly in the treatment group before and after the treatment, while in the control group,the SAS, SDS score did not changed statistically. Conclusions cognitive behavioral intervention can effectively improve the anxiety and depression of leukaemia patients, and improve the quality of life and deserves further clinical promotion.

Ye Gui was praised in medical faculty for his knowledge and experience of nourishing fluid in stomach,however after reading his medical record all over,Ye Gui' academic idea of diffusing and obstruction-removing gastric yang in treating gastroenteropathy based on syndrome differentiation was more outstanding.The theory was based on "no vigorous gastric yang insulted easily gathered turbid yin".The concrete application features were in terms of "obstruction-removing and tonifying yangming meridians,and together treating liver and stomach","combination of diffusing and obstruction-removing gastric yang,warming spleen and removing obstruction in collaterals et al" and so on.Adopting the method of diffusing and obstruction-removing gastric yang at the right moment especially benefited the treatment of gastroenteropathy based on syndrome differentiation.

The present study describes the effects of carbamate anti-cholinesterase agents and other drugs on the binding sites and on the turnover of nicotinic acetylcholine receptors (N-AChR). The direct binding studies with 125I-?-Bungarotoxin have shown that the neostigmine, prostigmine, pyridostigmine, and ambenonium specifically blockada the N-AChR binding sites, but physostigmine has no directly effect on the N-AChR binding sites.Small dose of ambenomine increases degradation rate of surface N-AChR and it decreases the rate of new N-AChR incorporation into membrane. The bindings of sodium phenobabital to N-AChR sites are very similar to those of d-tubocurarine. The parathion(E605)has no direct bindes to N-AChR sites. The density of extrajunc-tional N-AChR sites is increased and the RBI is 1.46.

The dynamic changes of the transcriptional activities of the nuclei of the rat liver and skeletal muscle cells were observed in the 6th, 12th, 24th, 48th, and 72nd hours after the animals were inflicted with 30% TBSA third degree burns.It was found that the incorporation of [3H]-UTP into the liver cell nuclei in vitro increased significantly in the 6th and 12th postburn hours. The peak of elevation occurred in the 6th hour postburn (from 7408 ?690 cpm/50?g DNA of normal to 10175 ? 1227 cpm/50?g DNA, P

The present study reports direct effects of allosteric snake neurotoxin (MN-81) on the nicotinic acetylcholine receptor (N-AChR) and on the transmission of nuro-muscular junction. when one dose of MN-81 with 50 ?g/kg body weight was injected into the mice, the number of N-AChR binding sites was not changed. when one dose of MN-81 with 250 ng/kg body weight was injected, 23 per cent of total N-AChR were occupied by MN-81 molecules. But when repeated injection of MN-81 was carried out N-AChR binding sites were increased by about 34 percent. Assay of phrenic nerve-diaphragm showed that the low close of MN-81 increased contractile amplitude of isolated rat diaphragm and rabbit diaphragm in situ, while an increase in the concentration of MN-81 (10-4g/ml) led to blockade of nuromus-cular transmission.

OBJECTIVE:To establish the quality standard of Compound gaobo intranasal spray.METHODS: Rhizoma et Radix Ligustici,Mentha haplocalyx and Borneolum Syntheticum in the preparation were identified qualitatively by TLC,and the content of ferulic acid was determined by HPLC.RESULTS: Rhizoma et Radix Ligustici,Mentha haplocalyx and Borneolum Syntheticum were well-separated and distinctive in TLC.The linear range of ferulic acid was 0.292～0.876 ?g(r=0.999 9) and the average recovery was 97.97%(RSD=1.70%,n=6).CONCLUSION: The established standard is applicable for the quality control of Compound gaobo intranasal spray.

OBJECTIVE:To provide reference for clarifying the responsibility of hospital pharmacists to ensure the safety of intravenous infusion. METHODS: By combining personal experience,the author presented the ways for pharmacists to ensure safety of intravenous infusion such as by ensuring the rationality of prescriptions,guiding nurses to carry out medical order accurately and administer drugs correctly,guiding patients about drug use and offer guidance about the choice of infusion apparatus,etc. RESULTS & CONCLUSIONS: Pharmacists should apply the pharmaceutical knowledge gained to conduct an effective interference on the irrational use of intravenous drugs and cooperate with doctors and nurses to guarantee medication safety in intravenous infusion.