Objective To explore the mutual relationship of cognitive behavioral intervention and negative emotion of leukaemia patients. Methods According to hospital dual order, 120 patients were divided into the treatment group and the control group with 60 cases in each group, the control adopted routine treatment and nursing, upon this basis, the treatment group received cognitive behavioral intervention.Anxiety and depression of two groups were compared with SAS and SDS scale. Results SAS and SDS score changed significantly in the treatment group before and after the treatment, while in the control group,the SAS, SDS score did not changed statistically. Conclusions cognitive behavioral intervention can effectively improve the anxiety and depression of leukaemia patients, and improve the quality of life and deserves further clinical promotion.

Although respiratory distress syndrome( RDS) ,one of the most common cause of respira-tory failure in the very or extremely preterm infant,has not been yet the major disorder of death with advances of respiratory support;In fact,RDS often complicated with BPD which developed with the maturation of de-pendence,the outcome of BPD and its development step into the focus of modern NICU. Powerful evidence-based consensus and suggestions have been stated in early respiratory support for very and extremely preterm infant:Early nasal CPAP( nCPAP) should be the best alternative to intubation for very or extremely preterm infant with high-risk of RDS and RDS; Early administration of Pulmonary surfactant ( PS ) with suitable methods( InSurE,Intubation Surfactant Extubation or LISA,Less invasive surfactant administration);Individ-ual threshould for nCPAP or other noninvasive ventilation failure should be established,but early PS adminis-tration and gentle ventilation will decrease the incidence of ventilator-induced injury on failuring noninvasive ventilation;Noninvasive ventilation with the use of caffeine will short the duration of ventilation and improve the success of weaning off. All the strategies in respiratory support to prevent BPD for very preterm infant still need more practice sustain improvement since multiple causes account for the development of BPD.

Objective To investigate the effect of rosuvastain on the lung function and quality of life in patients with stable chronic obstructive pulmonary disease(COPD).Methods 88 patients with COPD were selected, they were divided into the research group and the control group by digital table method,each group had 44 cases. Traditional treatment was used to treat patients in the control group,the research group was treated with rosuvastain 20mg,1 time one day on the basis of the traditional treatment,all patients were treated for 6 months.Before treatment, 1 month after therapy and 6 months after therapy,the first second forced expiratory volume(FEV1 ),forced expiratory volume in first second(FEV1 ),forced vital capacity(FVC%)value and the patients'lung function were determined, the patients'quality of life was evaluated by the COPD Assessment Test (CAT).Results After1 and 6 months of therapy,the FEV1 ,FEV1/FVC of the two groups were higher than before treatment,and after 6 months of therapy,the FEV1,FEV1/FVC of the research group were (1.49 ±0.40)L,(59.35 ±5.51)% respectively,which were significantly higher than (1.28 ±0.31)L,(53.02 ±5.60)% of the control group(t=2.753,5.345,all P<0.05). After 1 and 6 months of therapy,the CAT scores of the two groups were lower than before treatment,and after 6 months of therapy,the CAT score of the research group was (17.27 ±3.32)points,which was significantly lower than (21.25 ± 4.51)points of the control group(t=-4.714,P<0.05).Conclusion Rosuvastain can improve lung function and quality of life in patients with COPD,the clinical curative effect is distinct,and it is worthy of popularization and application.

There are more complicated pathological changes in the developing brain with invasive infection of central nervous system(CNS) which absolutely play predominant role in neurodevelopmental disability and mortality in spite of a lower prevalence during neonatal period.Bacterial meningitis demonstrated by cerebrospinal fluid(CSF) culture only remain difficult since poor positive findings,in the severe condition more complications could be often found such as vasculitis,ventriculitis,cerebritis and abscess.Cerebral abscess could be found independently without abnormal CSF examination;while the cerebritis is one of the primary pathological changes in viral invasive infection of CNS,Enterovirus/human parechovirus often involved not only grey matter,but also the periventricular and subcortical white matter that sound similar to the findings of periventricular leukomalacia on magnetic resonance imaging(MRI).Finding the complications of CNS infections early and accurately describe pathological changes by reasonable using MRI can enhance the therapy and predictive ability.

OBJECTIVE:To establish a method for the simultaneous determination of geniposide,paeoniflorin,berberine hy-drochloride,baicalin and paeonol in Qingwei huanglian pill. METHODS:HPLC was performed on the column of Diamonsil C18 with mobile phase of acetonitrile-0.3% phosphate(gradient elution)at flow rate of 1.0 ml/min,detection wavelength was 238 nm, column temperature was 30 ℃ and the injection volume was 10 μl. RESULTS:The linear range was 15.36-153.6 μg/ml for genipo-side, 6.56-65.6 μg/ml for paeoniflorin, 22.74-227.4 μg/ml for berberine hydrochloride, 26.06-260.6 μg/ml for baicalin and 5.57-55.7 μg/ml for paeonol(r≥0.999 8);RSDs of precision,stability and reproducibility tests were not higher than 1.0%;recov-eries were 96.28%-99.38%(RSD=1.1%,n=6),97.13%-99.48%(RSD=1.2%,n=6),98.14%-100.25(RSD=0.7%,n=6), 97.38%-100.05%(RSD=1.0%,n=6) and 96.30%-99.12%(RSD=1.2%,n=6),respectively. CONCLUSIONS:The method is simple and good reproducibility,and suitable for the contents determination of geniposide,paeoniflorin,berberine hydrochloride, baicalin and paeonol in Qingwei huanglian pill.

The STAT3 protein is a key transcription factor that delivers extracellular signals into nuclei in which it binds to a specific recognition element on DNA sequences and thus regulates the transcription of its target genes.STAT3 is almost expressed in all tissues and cells, therefore, it is extensively involved in both normal and aberrant cellular activities.For example, STAT3 plays an essential role in inflammatory reaction and tumorigenesis.STAT3 has been established as a therapeutic target of various cancers including multiple myeloma,a hematological malignancy from plasma cells.Some STAT3 inhibitors have been developed and extensively studied.In this article, we review the roles of STAT3 in multiple myeloma.The advances and strategies in the development of STAT3 inhibitors are also being discussed.

The social demand for mental health and psychological treatment has increased,but the effective psychotherapy for contemporary people is not much.Naikan cognitive therapy proved to be a kind of adaptation to disease extensive,simple and normative operation,cura the therapy following development in practice and improvement more than 20 years.In this article Naikan cognitive therapy theory research,mechanism,treatment process,techniques,mode of operation and effect of application were focused.Naikan cognitive therapy theory and operation and related problems of system is introduced to provide basis and guidance for the study and application of Naikan cognitive therapy.

AIM: To investigate the clinical effect of carbomer eye gel combined with polyethylene glycol eye drops on the treatment of dry eye. ·METHODS:Totally 120 dry eye patients(240 eyes) were randomly divided into the observation group ( n = 60 cases) and the control group ( n=60 cases) . Two groups were given the polyethylene glycol eye drops. On the basis of this, the observation group were given the carbomer eye gel. The course of treatment was 1mo. The levels of IL-1β and TNF-α, eye symptom score [ ocular surface disease index ( OSDI ) , break-up time ( BUT ) , Schirmer Ⅰ test ( SⅠt ) , corneal fluorescein staining ( FL) ] , efficacy and adverse reactions in two groups were compared. ·RESULTS: After treatment, the levels of IL-1β and TNF-α, OSDI and FL in two groups were significantly lower than those before treatment and BUT and SⅠT were significantly higher than those before treatment, showing statistically significant differences ( P< 0. 05 ). Moreover, the levels of IL-1β and TNF-α, OSDI, BUT, SⅠT, FL in the observation group were improved better than those in the control group ( P<0. 05 ). The total effective rate of the control group was significantly lower than that of the observation group, indicating statistically significant difference (x2=5. 065, P=0. 024). There were no ocular symptoms and drug intolerance in two groups. · CONCLUSION: Carbomer eye gel combined with polyethylene glycol eye drops has obvious curative effect on dry eye, which is better than that treated by polyethylene glycol eye drops, and this combination does not increase the adverse reactions.

The American College of Gastroenterology( ACG)released the first clinical guideline for drug-induced liver injury( DILI)in June,2014:the diagnosis and management of idiosyncratic drug-induced liver injury( IDILI), which includes all aspects of IDILI,such as risk factors,diagnosis,differential diagnosis and treatment. The guideline discusses especially the issues on herbal and dietary supplements( HDS)induced liver injury and DILI in patients with chronic liver disease. The guideline is of great value for standardizing the clinical diagnosis and treatment,providing the best recommendations for management of the patients with DILI. Since the evidence of research in the field of DILI is relatively weak at this moment,the clinicians should consider the possible individual difference of the patients under the frame of guideline for making the best clinical decision.

Current definition of apnea of prematurity (AOP) with the time of breathing cease equal or more than 20 seconds,or less than 20 seconds accompanying with bradycardia and(or) cyanosis was absence of strong clinical evidence and arbitrary.We have no consensus on the treatment of AOP,but severe AOP will lead to the intermittent hypoxic episodes(IHE) and severe fluctuation of oxygen saturation associated with severe retinopathy of prematurity and bad neurodevelopmental outcome.IHE occurred not only due to AOP,but also in the processes of continuous positive airway pressure and invasive ventilation.Decreasing the IHE is one of key problems of preterm respiratory support.Optimal target oxygen saturation should be regulated dynamically,the target oxygen saturation of 90％ ～ 95％ lowers IHE and mortality,but likely increases retinopathy of prematurity.Caffeine,the first choice of AOP,may be no of effect in the mixed or obstructive AOP which may need more respiratory support to reduce the lung volume loss and airway resistance.