NO is an important signal factor existing in expiratory air of normal person.Different kinds of airway inflammation can cause the increase of NO,especially eosinophilic inflammation.Fractional exhaled nitric oxide(FENO) can result in airway inflammation,which is noninvasive,repeatable and easily performed.It can be very helpful in the diagnosis and differential diagnosis of airway symptoms such as recurrent wheezing and chronic cough.It can also help determine the state of the disease and prognosis.It is a very useful tool in the assessment and management of airway diseases,especially asthma.

Zinc supplementation can reduce the mean duration,the recurrence rate and mortality of diarrhea.Nonetheless,it has no effect on stool frequency or stool output.Zinc supplementation results in different effort for the difference of the duration of diarrhea,pathogens,zinc type and doses of zinc,and shows no effect in infants younger than 6 months.Using iron as a co-intervention can reduce the effect of zinc,but vitamin A or ORS have a synergistic effect with the meeting.Average baseline zinc levels did not contribute to variations in the effect size.Zinc supplements are unlikely to improve compliance with the treatment for diarrheal disease.Longer course,zinc alone,malnutrition,diarrhea,breast-feeding children are prone to vomiting after oral administration of zinc.

In order to make the comprehensive evaluation work of intellectual property of TCM industry more scientific and reasonable in our country, promote the protection of intellectual property of TCM industry, based on the survey of the domestic and foreign literature about evaluation of intellectual property and TCM industry, this article built the evaluation index system of intellectual property of TCM industry from five aspects:the number of intellectual property, the quality of intellectual property, the development of intellectual property, the implementation of intellectual property, and the management of intellectual property, and elaborated each index in detail.

Objective　To research the anterior corneal stromal puncture therapeutic effect for bullous keratopathy.Methods　The causes of the bullous keratopathy of the 11 cases were analysed and the bullous keratopathy was cured by the anterior stromal puncture methods.Results　Eleven cases were followed up for three months.The symptoms were relieved in all cases. The corneal bullous disappeared.Conclusion　The cases of the bullous keratopathy caused by mechanical or physical factors can be cured more effectively by using anterior corneal stromal puncture therapeutics.

AIM: To analyse the main chemical constituents of Shuanghuanglian Injection Power(Flos lonicerae japanicae,Radix scutellariae and Fructus forsythiae) by high performance liquid chromatography-electrospray ionization-mass/mass spectrometry. METHODS: The sample solution was analysed by a Zorbax C_18 column with a gradient mobile phase comprised of acetonitrile and water.Electrospray ionization mass spectrometry detector was used,full-scan detection mode was evaluated for the identification of the liquid chromatography peaks. RESULTS: To analyse the mass spectrum of every liquid chromatography peaks,we identified 18 molecular mass from the ion chromatogram of Shuanghuanglian Injection Powder,9 compounds were identified,including quinic acid,caffeic acid,three monocaffeoylquinic acids,dicaffeoylquinic acid,forsythin,forsythoside and baicalin. CONCLUSION: Quinic acid is identified from Shuanghuanglian Injection Power for the first time.High performance liquid chromatography-mass/mass spectrometry is emerging as an important tool in traditional Chinese medicine.

Medicine, Chinese Traditional ; Terminology as Topic ; Translations

European Union (EU) medical device supervision system is more complete, has a lot of experiences and characteristics worth learning. This paper introduces a brief overview of the process of medical devices market in the EU, including three core medical device directives, process of obtaining CE mark, medical devices vigilance system and supervision after obtaining the CE mark, etc. Simultaneously, preliminary enlightenments of the EU medical devices supervision to our national medical devices' technical review process are discussed with the aim of providing reference for supervision, technical review unit and manufacturer.
Device Approval ; European Union ; Product Surveillance, Postmarketing

Objective To explore the clinical correlation of coronary heart disease with diabetes.Method From January 2005 to December 2008,268 patients were enrolled and randomly divided into the study group(Coronary Heart Disease combined with Diabetes)and the control group(Coronary Heart Disease).Blood pressure,hyperlipemia,degree of vasculopathy and chief heart incident was compared.Result The rate of blood pressure,hyperlipemia and chief heart incident in the control group were significantly lower than the study group(P＜0.05).The incidence rates of multi-branches lesions in the control group were significantly lower than the study group(P＜0.05).The incidence rates of single-branches lesions in the study group were significantly lower than the control group(P＜0.05).Conclusion Active measures should be taken to prevent diabetes and control the risk factors like blood sugar,blood fat,blood pressure,weight and so on in order to prevent the attack of coronary artery diseases.

BACKGROUND: The mental health of primary school teachers who have been working in remote mountain areas for a long time can be affected by the environment and conditions there.OBJECTIVE: To analyze the present mental health of mountain-area teachers to seek countermeasures of raising their mental health level.DESIGN: An investigation of random sampling questionnaires was carried out with the primary school teachers in remote mountain areas as observational subjects.SETTING: Department of Education, Xinzhou Teachers' Training Institute.PARTICIPANTS: From December 2003 to February 2004, 182 teachers who were randomly sampled from the 28 most remote mountain schools selected from seven counties and cities such as Wutai, Shenchi and Hequ in Shanxi Province, were selected as investigation subjects.METHODS: The self-assessed/measured symptom scale was used to assess the mental health of mountain area teachers. The scale was made up of 90 items, including 9 factors such as somatic disorder, obsessive disorder, interpersonal sensitivity, anxiety, depression, hostility, horror, paranoia,and psychoticism. There were 5 scaling levels: 1 shows 'never', 2 shows'mild', 3 shows 'moderate', 4 shows 'rather serious' and 5 shows 'severe'. Evaluation standard: If the factor score ≥ 2, they had mild symptoms; if any factor score ≥ 3, they were regarded as probably having mental problems above moderate degree. The major statistical indexes were the 9 factor scores, detection rate of moderate pain (factor score ≥ 3) and positive item number (factor score ≥ 2), all of which were compared with the national normal norm.MAIN OUTCOME MEASURES: The mental health of male/female teachers and teachers of different ages in mountain areas.RESULTS: Totally 182 copies of questionnaire were distributed, and 146of them were collected, with an effective rate of 80.2%. ① The total detection rate of psychological problems was 51.7%, in which male teachers made up 48.8% while female teachers 53.3%. Those with psychological problems above moderate level constituted 6.1%, of which male teachers held 1.4% and female teachers held 4.8%. The detection rate of each psychological problem among teachers of mountain areas ranged from2.1% to 12.3%. The symptoms ranked in detection rate from high to low were obsessive disorder, anxiety, interpersonal sensitivity, depression, somatic symptom, psychoticism, paranoia, horror and hostility. ② The total score and total average score of self-assessed/measured symptom inventory of mountain area teachers were obviously higher than those of the normal norm. The number of positive items was smaller than that of the normal norm, but the average score of positive items was obviously higher than that of the normal norm. It showed that the level of mental health of mountain area teachers was generally lower than that of normal population in the nation. ③ All the factor scores on the self-assessed/measured symptom inventory of mountain area teachers were obviously higher than the level of national normal population (P ≤ 0.01). ④The number and average score of positive items of mountain area female teachers were higher than those of the male teachers. The factor scores on interpersonal sensitivity, depression and anxiety of the female teachers were higher than those of the male teachers with significant difference (P ≤ 0.05). ⑤The average score of positive items and the score of the factors such as somatic symptom and horror of the teachers aged ≥ 30 years old were significantly higher than those of the teachers aged under 30 years old (P≤ 0.01).CONCLUSION: The detection rate of psychological problems of mountain area teachers was relatively higher, which were mainly presented as obsessive disorder, interpersonal sensitivity, anxiety, depression, and somatic symptom. On the self-assessed/measured symptom inventory of the mountain area teachers, the total score, the total average score, the average score of positive items and the score of each factor were obviously higher than those of the national normal population. The incidence rate of psychological problems of the female teachers was higherthan that of the male teachers. The mental health leve1 of teachers aged 30 years old or above was relatively lower.

Both innate and adaptive immunity contribute to the pathogenesis of ischemia-reperfusion injury (IRI).During acute phase of kidney IRI,kidney endothelial cells promote inflammation after IRI by increasing adhesion molecule expression and vascular permeability,and tubular epithelial cells increase complement C3 binding and Toll-like receptor 2 and Toll-like receptor 4 expression.Early activation of kidney dendritic cells initiates a cascade of events leading to accumulation of neutrophils,macrophage,natural killer cells,CD4 + T cells and B cells in the early phase of renal IRI.Soluble components of the immune system,such as complement activation production,cytokines and chemokines,also are implicated in the injury and repair of post-ischemic kidneys.Foxp3 + regulatory T cells and alternatively activated macrophage participate in attenuating the inflammation and initiating the repair of kidney IRI,while B lymphocytes limit repair of kidney IRI.