1.Neural Stem Cells.
Journal of the Korean Medical Association 2002;45(6):695-710
Multipotent neural stem cells (NSCs) are operationally defined by their ability to self-renew, to differentiate into cells of all glial and neuronal lineages throughout the neuraxis, and to populate developing or degenerating CNS regions. Thus their use as a graft material can be considered analogous to hematopoietic stem cell-mediated reconstitution and gene transfer. The recognition that NSCs propagated in culture could be reimplanted into mammalian brain, where they might integrate appropriately throughout the mammalian CNS and stably express foreign genes, has unveiled a new role for neural transplantation and gene therapy and a possible strategy for addressing the CNS manifestations of diseases that heretofore has been refractory to intervention. We have tracked the response of host and transplanted NSCs to brain or spinal cord injury and explored the therapeutic potential of NSCs injected into the animal CNS subjected to focal hypoxic-ische-mic (HI) brain or spinal cord injury. Such cells integrated appropriately into the degenerating CNS, showed robust engraftment and foreign gene expression within the region of CNS injury, and appeared to have migrated preferentially to the site of injury, experienced limited proliferation, and differentiated into neural cells lost to injury, trying to repopulate the damaged CNS area. The transplantation of exogenous NSCs may, in fact, augment a natural self-repair process in which the damaged CNS "attempts" to mobilize its own pool of stem cells. Providing additional NSCs and trophic factors may optimize this response. Therefore, NSCs may provide a novel approach to reconstituting CNS damaged by HI brain or spinal cord injury. Preliminary data in animal models of hypoxic-ischemic brain injury or contusive spinal cord injury lend support to these hypotheses.
Animals
;
Brain
;
Brain Injuries
;
Gene Expression
;
Genetic Therapy
;
Models, Animal
;
Neural Stem Cells*
;
Neurons
;
Spinal Cord Injuries
;
Stem Cells
;
Transplants
2.Aplastic Anemia.
Korean Journal of Pediatrics 2004;47(Suppl 2):S242-S256
No abstract available.
Anemia, Aplastic*
3.Investigation of renal function test and urinalysis findings onhepatitis B surface antigen positive patients.
Korean Journal of Clinical Pathology 1992;12(1):19-24
No abstract available.
Antigens, Surface*
;
Humans
;
Urinalysis*
4.Mixed chimerism after hemopoietic stem cell transplantation.
Korean Journal of Medicine 2000;58(4):371-373
No abstract available.
Chimerism*
;
Stem Cell Transplantation*
;
Stem Cells*
5.A clinical and anatomical study on the alveolar foramine in Korean.
Korean Journal of Physical Anthropology 1993;6(2):191-200
No abstract available.
6.An Experimental Study on the Allergic Contact Dermatitis from Applied ingredients of the Vehicle.
Korean Journal of Dermatology 1977;15(2):155-163
A group of chemicals that have proved to be frequent causes of allergic contact dermatitis from applied ingredients of the vehicle. Fisher (1971) testing with a vehicle tray of 15 chemicals in 100 patients with allergic contact dermatitis due to topically administered medications found 30 positive patch test reactions of patients and reported that most important sensitiiing chemicals are Ethylenediamine, Lanolin, Farabens, Phenylmercuric acid, and. propylene glycol monostearate. These chemicals have been recognized as such common sensitizers that they are nonincluded. in the standard patch test series by many countries. From the standpoint of allergenicity of topical preparations including topical medicaments and cosmetics, prevention and diagnostic procedures of dermatitis should be investigated extensively through the patch test studies. But, in our country, there has only a few investigation conceming the dermatitis from vehicle, particularly the medicaments and cosmetics. Therefore, author has tried to establish the vehicle tray fitted to our country according to the basic consideration used with the vehicle patch test tray of Fisher. 100 patients suspected of having allergic contct dermatitis due to topical medication or cosmetics were patch tested with a group of chemicals composed of substances commonly found in vehicles of current topical medications or cosmetics. There were many significant reactions to Ethylenediamine, Paraben, Lanolin, Sodium lauryl sulfate, Polyethylene glycol and Turpentine which play a significant role as solubilzer, antioxidants, emulsifieis, exirpients, preservatives, stabilizers, and surfactants. Author proposed that a group of chemicals should be patch tested on patients of allergic contact dermatitis for the establishmc,nt and development of the hypoallergenic topical medicaments or cosmetics.
Antioxidants
;
Dermatitis
;
Dermatitis, Allergic Contact*
;
Humans
;
Lanolin
;
Patch Tests
;
Polyethylene Glycols
;
Propylene Glycol
;
Sodium Dodecyl Sulfate
;
Surface-Active Agents
;
Turpentine
7.Investigation of renal function test and urinalysis findings onhepatitis B surface antigen positive patients.
Korean Journal of Clinical Pathology 1993;13(1):19-24
No abstract available.
Antigens, Surface*
;
Humans
;
Urinalysis*
8.Investigation of renal function test and urinalysis findings onhepatitis B surface antigen positive patients.
Korean Journal of Clinical Pathology 1993;13(1):19-24
No abstract available.
Antigens, Surface*
;
Humans
;
Urinalysis*
9.Vectical Transmission of Hepatitis B.
Journal of the Korean Pediatric Society 1983;26(5):412-412
No abstract available.
Hepatitis B*
;
Hepatitis*
10.The Last Fifty Years of Western Medicine in Korea: Korean Society of Pharmacology.
Journal of the Korean Medical Association 1997;40(8):949-957
No abstract available.
Korea*
;
Pharmacology*