1.Cystic Struma Ovarii Mimicking Adenomatous Goiter of the Thyroid.
Korean Journal of Pathology 1997;31(7):692-694
Struma ovarii, the most common monodennal teratoma of the ovary, causes diverse problems in differential diagnosis. The literature on the pathology of struma ovarii has focused principally on the problem of formulating criteria of malignancy. In contrast, unusual gross and microscopic features of struma ovarii and its resultant problems in differential diagnosis have received relatively little attention. We report an ovarian teratoma which was almost entirely cystic, causing the diagnosis of struma to be overlooked. The removed ovarian tumor showed all the features of adenomatous goiter of the thyroid gland. The lining epithelium of the cysts was frequently flattened, and the follicles in the cyst wall were few and atrophic. The patient was a 58-year-old woman who was found to have an ovarian tumor by routine monographic examination
Diagnosis
;
Diagnosis, Differential
;
Epithelium
;
Female
;
Goiter*
;
Humans
;
Middle Aged
;
Ovary
;
Pathology
;
Struma Ovarii*
;
Teratoma
;
Thyroid Gland*
2.Allergic Contact Dermatits due to Cambison Ophthalmic Ointment.
Kyung Ae JANG ; Jee Ho CHOI ; Kee Chan MOON
Korean Journal of Dermatology 1997;35(2):358-361
Cambison ophthalmic ointment is an easily available topical medicament in Korea, However, the allergic contact dermatitis lo Cambison ophthalmic ointment has not been reported in Korean dermatology literature. We report, a case of allergic contact dermatitis in a 28-year-old female who suffered from itchy, erythematous patches on both periorbital areas. She wore contact lenses and for the last year, she hac applied Cambison ophthalmic ointment to both periorbital areas. The skin lesions were aggravated gradually. A patch test showed positive reactions to Cambison ophthalmic ointment, neomycin, mercury and thimerosal. We suspect neomycin contained in Cambison ophthalmic ointment to be the etiologic agent. When contact dermatitis occurs on periorbital areas, topical ophthalmic ointment or lens cleaner may be considered as a causative agent.
Adult
;
Contact Lenses
;
Dermatitis, Allergic Contact
;
Dermatitis, Contact
;
Dermatology
;
Female
;
Humans
;
Korea
;
Neomycin
;
Patch Tests
;
Skin
;
Thimerosal
3.A Case of Cutaneous Larva Migrans.
In Kang JANG ; Dong Won LEE ; Baik Kee CHO
Korean Journal of Dermatology 1995;33(2):396-400
A 58-year-old male presented with a pruritic, erythematous hread-like eruption on the right chest, which appeared as a small papule since 6 months prior to his visit. Histopathologic examination showed a burrow containing numerous eosinophiles and a few mononuclear cells in the epidermis. There was focal spongiosis unde the burrow. In the dermis, there was a diffuse and occasionally dense perivascular and periadnx 1 inflammatory cell infiltration consisting of eosinophiles and some lymphocytes. Multiple histologic sections were made without success in deizo strating parasitic tissue in the epidermis, however, the clinical and histopathologic features we onsistent with cutaneous larva migrans.
Dermis
;
Eosinophils
;
Epidermis
;
Humans
;
Larva Migrans*
;
Lymphocytes
;
Male
;
Middle Aged
;
Thorax
4.Multilocular Cystic Renal Cell Carcinoma.
Myoung Jin JU ; Kee Tac JANG ; Je Geun CHI
Korean Journal of Pathology 1997;31(11):1240-1243
Multilocular cystic renal cell carcinoma is a distinct subtype of renal cell carcinoma with its pathological characteristics and good prognosis. Multilocular renal cysts and renal cell carcinoma with cystic change are important differential diagnoses. We report a case of multilocular cystic renal cell carcinoma in a 37-year-old woman who came to the hospital because of the right renal mass. The removed right kidney showed a 6x4 cm well defined cystic mass in the lower pole. On cut section there were multiple cavities in the mass, filled with serosanguineous fluid and focal yellowish solid area. Microscopically, these cysts were lined by a single layer of flat or cuboidal cells consisted of clear cytoplasm with small central nuclei. In some portions of the tumor, the clear neoplastic cells formed sheets within the septa or walls of the cysts.
Adult
;
Carcinoma, Renal Cell*
;
Cytoplasm
;
Diagnosis, Differential
;
Female
;
Humans
;
Kidney
;
Multicystic Dysplastic Kidney
;
Prognosis
5.Sarcomatoid Renal Cell Carcinoma; Special Reference to its Distinction from Carcinosarcoma.
Kee Taek JANG ; Yeon Mee KIM ; Je Geun CHI
Korean Journal of Pathology 1998;32(5):378-381
Sarcomatoid renal cell carcinoma is an uncommon tumor that has to be distinguished from renal carcinosarcoma. We have described three cases of sarcomatoid renal cell carcinoma showing different clinical and light microscopic features. An ultrastructural study of the tumor cells from the sarcomatoid area revealed frequent desmosomal junction, confirming the epithelial nature of the neoplasm. All three cases showed an aggressive clinical course and tended to invade adjacent organs or tissues. We believe that an histological and immunohistochemical examination in conjunction with an electron microscopic examination are necessary to diagnose sarcomatoid renal cell carcinoma.
Carcinoma, Renal Cell*
;
Carcinosarcoma*
;
Desmosomes
;
Microscopy, Electron
6.Psychological Study of Leprosy Patients - II . Leprosy Patients Admitted to the Hospital -.
Young Pio KIM ; Kee Yul JANG ; Inn Ki CHUN
Korean Journal of Dermatology 1983;21(2):153-163
Many factors including social rejection, family problems, loss of educational opportunity, fear, prejudice and ignorance of leprosy compound the inherent psychological stress of leprosy. In light of these problems this present study was undertaken to evaluate the psychological status of leprosy patients. The subjects of the present study were 205 patients admitted to a hospital and 304 control people living in similar isolated areas to resettlement villages. A self report symptom inventory, SCL-90 (symptom check list-90) was used and the groups were analysed and compared by many factors. (countinued..)
Humans
;
Leprosy*
;
Prejudice
;
Self Report
;
Social Distance
;
Stress, Psychological
7.A Case of Erythropoietic Protoporphyria.
Kee Yul JANG ; Kee Suk HUH ; Inn Ki CHUN ; Young Pio KIM
Korean Journal of Dermatology 1982;20(5):745-751
A 26-year-old male has experienced repeated pruritic and burning erythema and edema over the exposed areas of the skin, especially on the face and hands, after sunlight exposure. He stated that his father, three aunts, and three sisters had similar sunlight sensitivity. The face showed tiny whitish scars. And also there were hypopigmented scars on the dorsum of the hands. Characteristic laboratory findings were as followa: RBC, plasma and stool fluoresced coral red color under the Woods light. 100ml of the RBC contained 245 pg of protoporphyrin. On photosensitive test using sunlight for 60 rninutes, there developed painful sensation at 4 minutes and 40 seconds after exposure, erythema at 12 minutes after, and edema at 20 minutes after. Pathological findings of the specimen obtained from erythematous lesion of the forehead revealed hypergranulosis and acanthosis in the epidermis and perivascular thickening and hyalin deposit around the capillaries in the upper dermis. For treatment, avoidance of exposure to sunlight was recomrnended and symptomatic therapy was tried.
Adult
;
Anthozoa
;
Burns
;
Capillaries
;
Cicatrix
;
Dermis
;
Edema
;
Epidermis
;
Erythema
;
Fathers
;
Forehead
;
Hand
;
Humans
;
Hyalin
;
Male
;
Plasma
;
Protoporphyria, Erythropoietic*
;
Sensation
;
Siblings
;
Skin
;
Sunlight
;
Wood
8.Problems of Pathologic T Staging in Ampullary Neoplasm.
Korean Journal of Pancreas and Biliary Tract 2014;19(3):117-120
Ampulla of Vater (AoV) is a small dilated duct less than 1.5 cm long, formed by the union of pancreatic duct and common bile duct. AoV has also anatomic layer of mucosa, sphincter of Oddi, perisphincteric or duodenal submucosa, and duodenal proper muscle, which corresponds to mucosa, muscularis mucosa, submucosa, and proper muscle layer of other gastrointestinal tract organs, respectively. Because of its small compact size and variation of anatomic structure, it is sometimes difficult to identify layering architecture of AoV. This anatomic difficulty may cause some problem in T classification of ampullary carcinoma (AC). The most confusing point in T classification is the vague definition of T2, "Tumor invades duodenal wall". It seems that duodenal wall includes duodenal mucosa, submucosa, and proper muscle layer. However there is no precise description or definition about duodenal wall that might lead personal variation in T classification of AC staging. We found that clinical course of AC with perisphincteric and/or duodenal submucosal invasion is more close to AC with T2 than T1. Although it is described as T1b according to T classification scheme of ordinary gastrointestinal tract cancer, we thought AC with T1b may have more high-grade malignant potential than those of other gastrointestinal (GI) tract malignancy. AC showed various clinicopatholgic findings that represent heterogeneous tumor groups within category of AC. Recently site-specific classification of AC was introduced, and it showed relatively well-categorized clinical prognosis. It may be reasonable to understand site-specific tumorigenesis in AC. The standard gross protocol is needed to evaluate pathologic T classification of AC. In conclusion, ampullary neoplasm is composed of various subtypes, which require a separate approach according to anatomic epicenter of ampullary neoplasm. Although submucosal invasion in AC was classified into pT1b, its' biologic behavior is more close to pT2.
Ampulla of Vater
;
Carcinogenesis
;
Classification
;
Common Bile Duct
;
Duodenum
;
Gastrointestinal Neoplasms
;
Gastrointestinal Tract
;
Humans
;
Mucous Membrane
;
Neoplasm Staging
;
Pancreatic Ducts
;
Prognosis
;
Sphincter of Oddi
9.Telomerase Activity in Cervical Cancer.
Kyung Ah LEE ; Tae Kee JANG ; Young Jin JANG ; Young Gi LEE ; Doo Jin LEE ; Sung Ho LEE
Korean Journal of Obstetrics and Gynecology 2000;43(2):260-267
OBJECTIVE: Telomerase is a ribonucleoprotein that synthesizes TTAGGG repeats onto chromosome ends. The expression of telomerase is thought to be required for cellular immortality and carcinogenesis. This study was conducted to examine the telomerase activation occurs in cervical carcinogenesis. METHODS: The standard telomeric repeat amplification protocol(TRAP) was used to examine telomerase activity in tissues of 10 normal cervix, 10 carcinoma in situ, and 21 invasive cervical carcinoma. RESULTS: Telomerase activity was detected in tissues of 16/21(76.2%) invasive carcinoma, in 5/10(50.0%) carcinoma in situ, and in 3/10(30.0%) normal cervix. But the degree of telomerase activity in normal cervix was weak. There was significant difference in 3 groups(p<0.05). The results of neoadjuvant chemotherapy in 10 invasive cervical carcinoma were as follows. In 8 cases of which tumor size decreased more than 50%, 5 were positive for telomerase. In 2 cases that didn't respond to chemotherapy by tumor size, 1 was positive for telomerase. There was no significant difference between 2 groups. All of the 5 cases that had pelvic lymph node metastasis revealed positive telomerase activity, and the 11 cases of 16 cases that didn't have pelvic lymph node metastasis were positive for telomerase, but there was no significant difference in 2 groups. The positivity of telomerase activity in clinical stage of invasive cervical carcinoma was 73.3% in stage I(11/15), 75.0% in stage II(3/4), 100% in stage III(1/1), and 100% in stage IV(1/1), but there was no significant difference in each stages. CONCLUSION: Telomerase seems to be uniquely associated with malignant transformation of cervix and can be used as a tumor marker. Additional studies are needed to better clarify the biological significance of telomerase expression in cervical tumorigenesis.
Carcinogenesis
;
Carcinoma in Situ
;
Cervix Uteri
;
Drug Therapy
;
Female
;
Lymph Nodes
;
Neoplasm Metastasis
;
Ribonucleoproteins
;
Telomerase*
;
Uterine Cervical Neoplasms*
10.Pathological Classification of Panaeatic Cancer and Precancerous Casion.
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2004;8(3):127-132
The ductal system of the pancreas, which is responsible for carrying acinar secretion to the duodenum, is perhaps the smallest epithelial component of the pancreas. However, most pancreatic tumors are of ductal origin, and a majority of these are ductal adenocarcinomas. Pancreatic carcinomas of ductal type can be separated into several categories: 1. Conventional ductal adenocarcinoma (tumors that form small tubular glands with luminal and intracellular mucin and are associated with marked stromal desmoplasia). 2. Unusual histological patterns of conventional ductal adenocarcinoma (e.g., foamy gland pattern, large duct pattern, vacuolated pattern, lobular carcinoma-like pattern). 3. Other carcinomas of ductal origin (e.g., colloid carcinoma, adenosquamous carinoma, squamous cell carcinoma, and undifferentiated carcioma). Most tumors in this last category usually have an associated component of conventional ductal adenocarcinoma, which provides evidence of their ductal origin. Precursors of pancreatic ductal adenocarcinoma have been recognized as proliferative epithelium of the ducts. Some lesions with minimal cytologic atypia were not regarded to be neoplastic and were designated hyperplasia or metaplasia, but molecular study revealed most ductal proliferative lesions as neoplastic. Thus the entire spectrum of ductal proliferative lesion is referred to as pancreatic intraepithelial neoplasia (PanIN).
Adenocarcinoma
;
Adenocarcinoma, Mucinous
;
Carcinoma, Pancreatic Ductal
;
Carcinoma, Squamous Cell
;
Classification*
;
Duodenum
;
Epithelium
;
Hyperplasia
;
Metaplasia
;
Mucins
;
Pancreas
;
Pancreatic Ducts
;
Pancreatic Neoplasms
;
Phenobarbital
;
Precancerous Conditions