Objective To analyze the clinical effect of acupuncture combined with speech rehabilitation training in the treatment of dysarthria after stroke.Methods 88 patients with dysarthria after stroke were selected as study subjects,and they were randomly divided into the control group and the treatment group,44 cases in each group. The control group was treated with speech rehabilitation training,and the treatment group was treated with acupuncture combined with speech rehabilitation training.At the end of treatment,the dysarthria efficacy,a number of aand the incidence of adverse reactions were observed and compared between the two groups.Results The cure rate(9.09%) and total effective rate (77.27%)in the control group were significantly lower than those in the treatment group (25.00%,97.73%),and the differences were statistically significant(χ2 =3.94,8.42,all P <0.05).Before treat-ment,there was no significant difference between the two groups in the number of a(P >0.05),after treatment,the number of ain the control group was (7.39 ±3.67),which was significantly lower than (16.32 ±7.83)in the treatment group(t =4.20,P <0.05).The incidence rate of adverse reaction between two groups had no statistically significant difference(χ2 =3.11,P >0.05).Conclusion For post -stroke patients with dysarthria,acupuncture combined with speech rehabilitation training has good treatment effect,and the method can increase the number of aof patients,and has high security,it is worthy of widely application in clinic.

No abstract available.
Positive-Pressure Respiration, Intrinsic ; Airway Resistance ; Bronchitis, Chronic ; Lung Compliance ; Vena Cava, Inferior ; Work of Breathing ; Heart Ventricles ; Blood Pressure ; Pulmonary Disease, Chronic Obstructive ; Lung ; Respiratory Muscles ; Pulmonary Emphysema ; Emphysema ; Pneumonia ; Cardiac Output ; Lung Transplantation ; Intensive Care Units ; Positive-Pressure Respiration ; Barotrauma ; Hypotension ; Korea

BACKGROUND: Over the past several years, Clostridium difficile has become a major healthcare-associated pathogen. Fecal bacteriotherapy has been reported as an effective intervention for treating recurrent C. difficile infection by restoring the normal intestinal microbiota. METHODS: Articles on fecal bacteriotherapy were collected through PubMed, CINAHL, Cochrane Library, and Web of Science databases using the keywords "Clostridium difficile," "feces," "fecal transplantation," "fecal microbiota transplantation," and "fecal bacteriotherapy." Using a systematic literature review, variables of interest from articles that met the inclusion criteria were extracted and summarized. RESULTS: Among 141 articles that were published in English from January 1, 2000 to August 31, 2012, 8 studies were selected for analysis after assessing the titles, abstracts, and full contents. Fecal bacteriotherapy procedures varied with respect to donor selection, screening, infusion route, and preparation of the suspension. Donors were mostly family members or relatives, and donor screening included tests for blood borne and stool pathogens. Selected infusion routes were colonoscopy (62.5%), nasogastric tube (25%), and enema (12.5%). The success rate was reported to be 73-100%. There was a lack of a standard procedure for fecal bacteriotherapy in all of the selected studies. CONCLUSION: Fecal bacteriotherapy is an effective intervention for combating C. difficile infection that has a high success rate and no adverse effects. This therapy would be helpful for infection control in hospital settings by facilitating early eradication of C. difficile infection.
Clostridium ; Clostridium difficile ; Colonoscopy ; Donor Selection ; Enema ; Feces ; Humans ; Infection Control ; Mass Screening ; Metagenome ; Tissue Donors

No abstract available.
Animals ; Antibodies* ; Antibodies, Anticardiolipin ; beta 2-Glycoprotein I* ; Mice* ; T-Lymphocytes, Helper-Inducer*

Currently the highly active anti-retroviral therapy (HAART) is the most effective and practical approach for AIDS treatment. However, as the public health strategy for HIV/AIDS prevention and control, governmental involvement is highly needed. Since 2004 Chinese govemment actively responded to the United Nations' proposition and promised, "Four Free and One Care" policy, to promote HAART for AIDS patients in whole country, which was free of charge for all the AIDS patients. HIV related testing technologies are important assurance for effective implementation of HAART and replacement of anti-HIV drugs, including screening and confirmation of HIV/AIDS patients, screening of patients for HAART, evaluation of treatment effcacy and side effects, monitoring HIV-1 drug resistance and molecular evolution. In this issue, there are 6 papers describing the research on HAABT and relevant HIV testing technologies. The studies clearly demonstrated that great development was made in HIV testing technologies, which played significant supportive roles for HAART implementation in China.

The activation of CD40-CD40L costimulatory signal channel plays a necessary role in T cellmediated immune response. Activation of CD40 on antigen presenting cells by CD40L which expressed on Tlymphocytes, while contributing to the pro-in? ammatory response necessary for eradication of infection, accounts for the pathology in autoimmunity. Meanwhile, there is evidence that CD40 is also expressed on T-lymphocytes and can act as a costimulatory molecule. Further dissection of the exact nature and role of CD40 in T cell activation could lead the way to novel therapeutics for diseases which include organ-graft refection, autoimmune diseases,tumor, and inflammation.

Viruses including baculoviruses are obligatory parasites, as their genomes do not encode all the proteins required for replication. Therefore, viruses have evolved to exploit the behavior and the physiology of their hosts and often eoevolved with their hosts over millions of years. Recent comparative analyses of complete genome sequences of baculoviruses revealed the patterns of gene acquisitions and losses that have occurred during baculovirus evolution. In addition, knowledge of virus genes has also provided understanding of the mechanism of baculovirus infection including replication, species-specific virulence and host range. The Bm8 gene of Bombyx mori nucleopolyhedrovirus (NPV) and its homologues are found only in group I NPV genomes. The Autographa californica NPV Acl6 gene is a homologue of Bm8 and, encodes a viral structural protein. It has been shown that Bm8/Ac 16 interacts with baculoviral and cellular proteins. Bm8/Ac 16 interacts with baculoviral IE1 that is facilitated by coiled coil domains, and the interaction with IE1 is important for Bin8 function. Ac16 also forms a complex with viral FP25 and cellular actin and associates with membranes via palmitoylation. These data suggested that this gene family encodes a multifunctional protein that accomplishes specific needs of group INPVs.

Objective To observe the efficacy of the combined treatment of Reduning,budesonide and erythromycin sequential therapy in the treatment of children with mycoplasma pneumonia and investigate its mechanism.Methods 78 children with mycoplasma pneumonia were randomly divided into two groups,each group 39 cases.The control group were given budesonide and erythromycin sequential therapy,and the observation group were given Reduning injection on the basis of the control group.Both groups were treated for 2 weeks.The clinical efficacy was observed,and before and after treatment,the pulmonary function was tested in the both groups.Results The total effective rate of the observation group was 94.87％,which was higher than that of the control group(86.62％)(x2=6.683,P＜0.05);The fever,cough improved,pulmonary rales disappeared,wheeze disappeared and hospital stay time of the observation group were significantly shorter than the control group(all P＜0.01);The FVC,FEV1 and PEF of the observation group were higher than those of the control group(all P＜0.05).Conclusion On the basis of the combined treatment of budesonide and erythromycin,the addition of Reduning injection can improve clinical effect and shorten the symptoms and signs improve time,improve lung function,chich may in association with regulating humoral immunity and reducing the levels of inflammatory cytokines.

Objective According to the analyses of adverse drug reactions (ADR) in clinic, we supply reasonable drug information for clinical usage to reduce recurrence of adverse reactions. Methods Analyze the ADR reports of our hospital from April, 2007 to December, 2008 and make statistical analysis by terms of age of patients, kinds of drugs, route of administration, clinical manifestation, and recovery, etc. Result The incidence rate of ADR in the female is more than the male. ADR mainly involves with the skin, nervous system, respiratory system, and digestive system. Clinical manifestations mainly show as rash, local swelling, erythema, irritations, dizziness, headache, fever, sweating, shiver, chest tightness, short breath, heart palpitation, dyspnea, sickness, vomiting, abdominal pain and distension etc. Conclusion Antibiotics should be reasonably used; Traditional Chinese medicinal injection should be used according to syndrome differentiation and be avoided used with the combination with other medicines. Dosage and injecting speed should also be strictly controlled to reduce and avoid ADR happening again.

0.05). The results showed that Guar-facine did not bring about any genetic damage.