The sex cord tumor with annular tubules is a rare ovarian neoplasm the predominant component of which has morphologic features intermediate between those of the granulosa cell tumor and those of the Sertoli cell tumor; focal differentiation into either granulosa cell or Sertoli cell tumor may occur. It is microscopically characterized by the formation of simple and complex annular tubules with hyaline bodies and it occurs often in patients with Peutz-Jeghers syndrome. Recently author experienced a case of ovarian sex cord tumor with annular tubules in a 49 year old female without Peutz-Jeghers syndrome. Clinical data and histopathological findings of the case were discussed and a brief review of the literature on this entity, especially the relationship to Peutz-Jeghers syndrome and the pathological differences between the tumor associated with and without Peutz-Jeghers syndrome.
Female ; Humans

No abstract available.
Korea* ; Peritoneal Dialysis, Continuous Ambulatory*

No abstract available.
Peritoneal Dialysis*

No abstract available.
Humans* ; Insulin* ; Receptor, Insulin*

No abstract available.
Diabetes Insipidus*

BACKGROUND: The use of anesthesia during assisted reproductive technology (ART) such as TEST (Tubal Embryo Stage Transfer) may expose early embryo to anesthetics in tubal fluid. The effects of anesthetic agents on the development of early embryo in ART are yet unclear. The purpose of this study was to evaluate the effects of narcotics on mouse two-cell embryo development using in vitro growth model of mouse embryo. METHODS: Mouse two-cell embryos were exposed to narcotics, fentanyl (6.0 nM; 30.0 nM) and meperidine (1.0 M; 3.6 M) respectively. Mouse two-cell embryos unexposed to any drugs were served as controls. In vitro developmental patterns were observed on the third and fifth day of culture. RESULTS: There were no significant differences in the rates of embryos arrested at 2~8 cell stage on the third day after culture and blastocysts development and their hatching on the fifth day after culture among three groups. CONCLUSION: We conclude that fentanyl and meperidine in clinical therapeutic concentration have no detrimental effects on the in vitro two-cell mouse embryo development. But further investigations are required to determine whether narcotics have any adverse toxic effects in human reproductive medicine.
Anesthesia ; Anesthetics ; Animals ; Blastocyst ; Embryonic Development* ; Embryonic Structures* ; Female ; Fentanyl ; Humans ; Meperidine ; Mice* ; Narcotics* ; Pregnancy ; Reproductive Medicine ; Reproductive Techniques, Assisted

No abstract available.
Ovotesticular Disorders of Sex Development*

No abstract available.
Estradiol ; Growth Hormone* ; Testosterone

The effects of Cryosurgery of the ciliary body on the aqueous humor dynamics of ten albino rabbits were studied by perfusion experiments. The cryo-probe (tip diameter, 3 mm) was frozen by dry ice and alcohol mixture and applied over the full circumference of the eye 2 mm from the limbus for 30 seconds. Eight applications were made in each eye. Intraocular pressure fell during the first 10 days after surgery, the amount of fall averaged 2.5 mmHg (12.6% of the pre-treatment level). Thereafter the intraocular pressure rose gradually in all eyes and reached almost to the original level 3 weeks after surgery. Facility of outflow changed inconsistently, showing no definite pattern. Aqueous flow showed significant reductions during the 2 to 3 weeks after treatment, then gradually recovered. There was no significant reduction in flow after the end of 3 weeks. No complications were encountered except mild iridocyclitis during the first week. The unsatisfactory outcome of this cryotherapy is considered to be due to the insufficient freezing of the ciliary body, and more applications is recommended in order to produce more sustained reduction of intraocular pressure.
Aqueous Humor ; Ciliary Body ; Cryosurgery ; Cryotherapy ; Dry Ice ; Freezing ; Intraocular Pressure ; Iridocyclitis ; Perfusion ; Rabbits*

Hepatic blood flow was studied by the determination of the fractional clearance of intravenously administered colloid 198Au in 35 cases of normal subjects, 36 cases of liver cirrhosis, 18 cases of primary cancer of the liver, seven cases of liver abscess, five cases of hepatitis and 10 cases of hepato-biliary diseases. There was no appreciable difference in the mean values of the fractional clerance between the normal subjects and biliary tract diseases. On the contrary, it was diminshed in liver cirrrhosis, primary cancer of the liver, hepatitis and liver abscess compared with that in the normal subjects, and the diminution in liver cirrhosis and primary cancer of the liver was significant, and also the fractional clearance in the former was significant, and also the fractional clearance in the former was significantly smaller than that in the latter. However, the individual datum both in the normal control and diseased groups showed a marked overlapping among them except that in the normal subjects and biliary tract diseases the fractional clearance was above 0.10 in almost all cases. In cirrhosis of the liver there was no relationship between the fractional clearance and liver functions.
Biliary Tract Diseases ; Colloids ; Fibrosis ; Hepatitis ; Liver ; Liver Abscess ; Liver Cirrhosis ; Liver Neoplasms