BACKGROUND:Aerobic exercise has an anti-atherosclerosis effect and some Chinese herbal components have some interventional effects on the atherosclerosis vulnerable plaque. OBJECTIVE:To observe the effects on lipid metabolism and adhesion molecules of atherosclerotic elderly rats after the interventions of Poria compound and aerobics exercise, and explore the mechanism and prevention of hyperlipidemia-induced atherosclerosis. METHODS:Forty Spraque-Dawley elderly rats, of specific pathogen free level, were randomly divided into four groups: control group, model group, medication group, and intervention group, with 10 rats in each group. Rats in the control group were normaly fed, while rats in the other groups were intraperitonealy injected with vitamin D3 and high-fat forage for 16 weeks, to establish atherosclerosis model. During the model establishment, rats in the medication and intervention groups were given 20 g/kg Poria compound and Poria compound + 1-hour swimming, respectively. RESULTS AND CONCLUSION:Compared with the control group, total cholesterol, serum triglyceride, low-density lipoprotein expression, intercelular cel adhesion molecule-1 and lymphocyte function association antigen-1 concentrations were increased in the model group. Compared with the model group, these indexes were obviously increased in the medication and intervention groups. The serum triglyceride and low-density lipoprotein expression in the intervention group were lower than those in the medication group, while the serum high-density lipoprotein expression was higher than the medication group. Experimental findings indicate that, the combined interventions of Poria compound and aerobics exercise is better than Poria compound alone, and multi-factor treatment of atherosclerosis should be taken to enhance the efficacy of colaborative approach.

OBJECTIVE:To provide legal basis for purchasing drugs by centralized bidding.METHODS:On the basis of the relevant laws,to expound the process of purchasing drugs by centralized bidding and the standards that should be observed. RESULTS ＆ CONCLUSION:Purchasing drugs by centralized bidding should observe the public bidding law of the People's Republic of China,only by observing the law can it benefits the nation and the people.

0.05) .The expression of PTEN and p27 in gastric cancer correlated with each other(r=0.3043,P

OBJECTI VE:To arouse the attention of pri marylevel medical institutions to the pharmaceutical administrationwork.METHODS:Rational proposals and strategies ai med at the problems were put forward by investigation the status quo ofthe pharmaceutical administrationinthe pri marylevel medical institutions.RESULTS &CONCLUSIONS:Policies andlaws ®ulations should be strengthenedin the pri mary level medical institutions so as to i mprove their cognition on pharmaceuticaladministration ; hardware facilities should be i mproved so as to establish a favorable hospital i mage ; Supervision should bestrengthened to facilitate the launching of pharmaceutical administration extensively ;‘People -centered’approach should beemphasized and fully attention should be given to the culture of talents.

PTEN is a tumor suppressor with double specific phosphatase activity,and PTEN brings into its lipid and protein phosphatase activity through PIP3, FAK, MAPK pathway. PTEN also induces apoptosis, inhibits cell growth, and regulates cell migration and adhesiveness. PTEN expression is lower in gastric carcinoma. It may be valuable to evaluate that the abnormal expression of suppressor gene PTEN participates in the malignant conversion process of the gastric mucosa cell, and the expression levels of the PTEN protein can be used to evaluate the pathologic biology behavior of gastric carcinoma.

Endocardial myocardial biopsy is the gold standard in the diagnosis of viral myocarditis.However,the limitations of sampling to the low sensitivity,and invasive inspection methods limit its clinical application.The traditional diagnostic tool electrocardiography,laboratory values and echocardiography are lack of specificity.Thus,a non-invasive diagnostic approach with high sensitivity is in need.Cardiovascular magnetic resonance(CMR) can evaluate the function of the heart parameters,such as left ventricular function and regional wall motion,and various CMR imagings including T2-weighted imaging,and early- and late-contrast enhanced T1-weighted imaging can evaluate the hyperemia,oedema and necrosis of myocardial inflammation histological character.CMR provides a scientific basis for the diagnosis of viral myocarditis in clinical.

Enteral nutrition therapy is the first choice of clinical nutrition therapy method in children with disease.We should make full use of the gastrointestinal function and total nutritional therapy.The key is based on gastrointestinal function choose enteral nutrition infusion way,infusion pattern and prevention and treatment of refeeding syndrome.As following is introduction about a few problems.

Objective:The methods of hormone therapy prompt us to renewedly handle the perimenopausal dysfunctional uterine bleeding (DUB) and postmenopausal vaginal bleeding,search dangerous factors and optimize therapeutic schemes in order to reduce non-essential diagnostic curettage. Methods:45 perimenopausal women and 182 menopausal ones were choosed in our research and the following each index including the age of onset,body mass index,the course of diseases,excessive mentses,hypertension,diabetes, hormone replacement therapy,postoperative application of breast cancer,hypothyroidism,polycystic ovary syndrome or endometrial thickness was set as a variable to sdtudy the relationship between each variable and endometrial abnormity using Logistic regression analysis. Results:According to the Logistic regression analysis,there was a relevance between endometrial thickness and endometrial abnormity(endometrial hyperplasia & endometrial cancer)when the endometrial thickness was equal to or more than 7 mm during the perimenopause period (P=0.02),and so it was with the menopausal period when the endometrial thickness was equal to or more than 9 mm (P

OBJECTIVE To explore the condition of hand-washing compliance among clinic nurses,find the factors which influence the nurses hand-washing compliance,and discuss the countermeasures.METHODS Their behavior of hand-washing compliance among 119 clinic nurses was investigated randomly,78 clinic nurses were adopted hand-washing technical examination.RESULTS The hand-washing compliance rate before medical activities was 5.9%,but after medical activities was 29.4%.The hand-washing accurate rate was 56.0%.CONCLUSIONS Administrative personnel should adopt essential intervention,and enhance management and supervision of the hand-washing behavior to improve the hand-washing compliance and its quality.

Objective To investigate the feasibility and timing of laparoscopic cholecystectomy(LC) for the treatment of acute pancreatitis accompanying gallstones. Methods A retrospective analysis was made on clinical data of 21 patients with acute pancreatitis accompanying gallstones treated by LC between January 1999 and August 2003 in this hospital. Results The LC was performed 20~40 days after the onset of pancreatitis and 15 days after the recovery of serum and urinary amylase levels.An abdominal drainage tube was placed in 9 patients.Postoperative recovery was uneventful in 19 patients,who got out of bed on the surgery day or on the first postoperative day and began to take food 12 hours after operation,with the abdominal drainage tube removed 24~72 hours postoperatively and no complications encountered.Recurrence of acute pancreatitis happened in 2 patients on the 3 postoperative days and was relieved from symptoms with conservative treatment.The duration of postoperative hospital stay was 4~20 days(mean,7 days).Follow-up checkups in the 21 patients for 6 months ~ 5 years(mean,19 months) found no recurrence. Conclusions Laparoscopic cholecystectomy is feasible and safe for patients with acute pancreatitis accompanying gallstones in the period of 20~40 days after the onset of pancreatitis.Careful patient selection,proper peri-operative treatment,strict adherence to techniques,and use of postoperative drainage are considered essential.