1.A Case of Spontaneous Bacterial Peritonitis Caused by Listeria monocytogenes.
Byung Sihk KIM ; Tae Yeob KIM ; Ji Yeoun KIM ; Kyo Sang YOO ; Yong Chul JEON ; Dong Soo HAN ; Joo Hyun SOHN ; Jieun KIM
The Korean Journal of Gastroenterology 2013;62(3):179-181
Spontaneous bacterial peritonitis (SBP) is a life-threatening complication in patients with ascites caused by advanced liver disease. While gram negative bacteria, such as Escherichia coli and Klebsiella pneumonia are the common pathogens, Listeria monocytogenes has been recognized as a very rare pathogen. Empirical treatment with third generation cephalosporins does not provide adequate antibiotics coverage against L. monocytogenes. Diagnosis is often delayed as it requires confirmation from ascitic fluid culture. Herein, we describe the first case of SBP caused by L. monocytogenes in a patient with advanced alcoholic liver cirrhosis in Korea. Clinicians should be aware of the atypical pathogens, especially in patients with inadequate response to empirical antibiotics.
Ampicillin/therapeutic use
;
Anti-Bacterial Agents/therapeutic use
;
Ascites/microbiology
;
Humans
;
Listeria monocytogenes/*physiology
;
Listeriosis/*diagnosis/drug therapy
;
Liver Cirrhosis, Alcoholic/*diagnosis
;
Male
;
Middle Aged
;
Peritonitis/*diagnosis/*microbiology
2.The neuroprotective effects and its mechanisms of qingkailing injection on bacterial meningitis induced by E. coli in rabbits.
Shao-jie YUE ; Qiao-jun LI ; Zi-qiang LUO ; Feige TANG ; Deyun FENG ; Shilin DENG ; Peilan YU
Chinese Journal of Integrated Traditional and Western Medicine 2005;25(7):633-636
OBJECTIVETo explore the neuro-protective effect and mechanism of qingkailing injection (QKL) against cerebral injury caused by E. coli-meningitis (CM).
METHODSThe CM model rabbits were treated by ampicillin with QKL as adjuvant. The leukocyte count and protein content in cerebral spinal fluid (CSF), the contents of water, sodium, potassium and calcium in cerebral tissues were measured before, 16 h and 26 h after Bacillus coli injection respectively. The expression of matrix metalloproteinase-9 (MMP-9) was determined at the same time.
RESULTSAdjunctive treatment with QKL can not only inhibit the increase of leukocyte cells, protein content in CSF, and water, sodium, calcium content in cerebral tissues, but also the decrease of potassium content revealed during simple antibiotic treatment. It also can decrease the expression of MMP-9 in cerebral tissues of rabbits with CM.
CONCLUSIONAs an adjunctive treatment, QKL can prevent transient inflammatory reaction and aggravation of brain injury in CM induced by simple antibiotic treatment, its mechanisms might relate with calcium antagonism and attenuation of MMP-9 expression in brain tissues.
Ampicillin ; therapeutic use ; Animals ; Anti-Bacterial Agents ; therapeutic use ; Brain ; metabolism ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Injections ; Male ; Matrix Metalloproteinase 9 ; biosynthesis ; Meningitis, Escherichia coli ; drug therapy ; Neuroprotective Agents ; therapeutic use ; Phytotherapy ; Rabbits
3.A Case of Liver Abscess Caused by Fusobacterium nucleatum in a Patient with Recurrent Periodontal Diseases.
Yong Hwan KIM ; Hee Jung YOON ; Chan Woong PARK ; Jung Ho KIM ; Min Kyung LEE ; Ki Bang KIM ; Dong Jib NA ; Ji Myung KIM
The Korean Journal of Gastroenterology 2011;57(1):42-46
Fusobacteria are anaerobic gram-negative, non-spore forming bacilli found in normal flora of the oral cavity, urogenital tract, and gastrointestinal tract. Fusobacterium nucleatum has been seldom reported as a cause of liver abscess, particularly in immunocompetent hosts. A 55-year-old man with frequent periodontal disease visited our hospital with intermittent fever and headache for 2 months. Abdominal CT scan revealed an 8.2x6 cm mass in the right hepatic lobe with central low density. Abscess culture revealed F. nucleatum as the causative organism. Percutaneous abscess drainage and intravenous administration of antibiotics for 4 weeks improved symptoms and decreased the abscess size. We report a rare case of liver abscess due to F. nucleatum in an immunocompetent man with periodontal disease.
Ampicillin/therapeutic use
;
Anti-Bacterial Agents/therapeutic use
;
Fusobacterium Infections/complications/*diagnosis/drug therapy
;
Fusobacterium nucleatum/*isolation & purification
;
Humans
;
Injections, Intravenous
;
Liver Abscess/*diagnosis/etiology/microbiology
;
Male
;
Middle Aged
;
Periodontal Diseases/*diagnosis
;
Sulbactam/therapeutic use
4.Actinomycosis in Pancreas and Psoas Muscle.
Yoon Jung LEE ; Min Ji LEE ; Jong Kyun LEE
The Korean Journal of Gastroenterology 2012;60(1):61-63
No abstract available.
Actinomycosis/*diagnosis/drug therapy/microbiology
;
Adult
;
Amoxicillin/therapeutic use
;
Ampicillin/therapeutic use
;
Anti-Bacterial Agents/therapeutic use
;
Endosonography
;
Female
;
Gram-Positive Bacteria/isolation & purification
;
Humans
;
Pancreas/ultrasonography
;
Psoas Muscles/ultrasonography
;
Tomography, X-Ray Computed
5.Antimicrobial susceptibility of Enterobacteriaceae causing urinary tract infections: a central military hospital study.
Chinese Medical Journal 2014;127(23):4150-4151
Ampicillin
;
therapeutic use
;
Anti-Infective Agents
;
therapeutic use
;
Enterobacteriaceae
;
drug effects
;
pathogenicity
;
Enterobacteriaceae Infections
;
drug therapy
;
microbiology
;
Female
;
Hospitals, Military
;
Humans
;
Male
;
Sulbactam
;
therapeutic use
;
Urinary Tract Infections
;
drug therapy
;
microbiology
6.Study on molecular epidemiology of major pathogenic Streptococcus suis serotypes in middle part of Jiangsu province.
Ai-Ping JU ; Chang-Jun WANG ; Feng ZHENG ; Xiu-Zhen PAN ; Ya-Qing DONG ; Jun-Chao GE ; Cheng-Ping LU ; Jia-Qi TANG
Chinese Journal of Epidemiology 2008;29(2):151-154
OBJECTIVETo determine the prevalence of Streptococcus suis and major pathogenic serotypes in middle part of Jiangsu province.
METHODSTonsillar specimens from 303 slaughtered pigs aged 6 to 8 months were investigated for the presence of Streptococcus suis and major pathogenic serotypes by polymerase chain reaction (PCR) method. Bacteriological examination compared with molecular genetics identification for three Streptococcus suis isolates were also done.
RESULTSThe overall carrier rate of Streptococcus suis was up to 88.0%, with the percentages of serotype 1(14), 2(1/2), 7 and 9 were 9.6%, 8.5%, 11.3% and 29.5% respectively in 2005. While in 2006, the prevalence of Streptococcus suis was 82.5%, with capsular types 1 (14), 2 (1/2), 7 and 9 were accounted for 17.6%, 2.4%, 25.8% and 20.0% of all the specimens. All the three isolates belonged to Streptococcus suis serotype 2,named 2a, 2f and 14e, which exhibiting the virulent phenotype cps2+/gdh+/mrp-/lepf-/sly-/fbps+/orf2+/89k-, cps2+/lgdh+/mrp-/epf-/sly-/fbps-/orf2-/89k- and cps2+/gdh+/mrp-/epf-/sly-/fbps/orf2-/ respectively. These isolates were all susceptible to amoxicillin, ampicillin, penicillin and resistant to amikacin and tetraycline. Clinical signs were not noted in BALB/c mice and rabbit.
CONCLUSIONPrevalence of the Streptococcus suis among the healthy herds in the areas was very high, with various capsule types of Streptococcus suis involved in the same herds, and the virulent phenotype of these 3 isolates were very different from those prevalent Streptococcus suis serotype 2 virulent isolates frequently discovered from the epidemic areas.
Amikacin ; therapeutic use ; Amoxicillin ; therapeutic use ; Ampicillin ; therapeutic use ; Animals ; China ; epidemiology ; Mice ; Mice, Inbred BALB C ; Molecular Epidemiology ; methods ; Penicillins ; therapeutic use ; Polymerase Chain Reaction ; Streptococcal Infections ; drug therapy ; epidemiology ; microbiology ; Streptococcus suis ; classification ; drug effects ; genetics ; pathogenicity ; Tetracycline ; therapeutic use ; Virulence
7.Clinical features and antimicrobial resistance of invasive non-typhoid Salmonella infection in children at Xiamen.
Cai Hong WANG ; Mei Lian HUANG ; Zhi Qiang ZHUO ; Zi Xuan WANG ; Lei CHEN ; Yi Qing SONG ; Hui YU
Chinese Journal of Pediatrics 2023;61(8):685-689
Objective: To investigate the clinical characteristics, serogroups and antimicrobial resistance of invasive non-typhoid Salmonella infection in children at Xiamen. Methods: Retrospective cohort study. The clinical manifestations, treatment, prognosis, serogroups and antimicrobial resistance of 29 hospitalized children with invasive non-typhoid Salmonella infection confirmed by blood, cerebrospinal fluid, bone marrow and other sterile body fluids or deep pus culture at the Department of Infectious Diseases, the Department of Orthopedics and the Department of General Surgery in Xiamen Children's Hospital from January 2016 to December 2021 were analyzed. According to the clinical diagnosis criteria, the patients were divided into sepsis group and non-sepsis group (bacteremia and local suppurative infection). The inflammatory markers, serogroups distribution and drug resistance were compared between the two groups. Comparison between groups using Mann-Whitney U test and χ2 test. Results: Among the 29 cases, there were 17 males and 12 females, with an onset age of 14 (9, 25) months, and 10 cases (34%) of patients were younger than 1 year old, 15 cases (52%) under 1 to 3 years old, and 4 cases (14%) greater than or equal 3 years old. The onset time of 25 cases (86%) was from April to September. The diseases included 19 cases (66%) septicemia (2 of which were combined with suppurative meningitis), 10 cases (34%) non-sepsis group, including 7 cases bacteremia and 3 cases local suppurative infection (2 cases of osteomyelitis, 1 case of appendicitis with peritonitis). The clinical manifestations were fever in 29 cases (100%), diarrhea and abdominal pain in 18 cases (62%), cough and runny nose in 10 cases (34%). Eighteen cases (62%) were cured and 11 cases (38%) were improved by effective antibiotics treatment. C-reactive protein in sepsis group was significantly higher than that in non-sepsis group (25.2 (16.1, 56.4) vs. 3.4 (0.5, 7.5) mg/L, Z=-3.81, P<0.001).The serogroups of C, B and E were the most prevalent among non-typhoid Salmonella isolates, accounting for 10 cases (34%), 9 cases (31%) and 7 cases (24%) respectively. Antibacterial drug sensitivity test showed that the sensitivity rates of imipenem, ertapenem and piperaciratazobactam were all 100% (31/31), those of ceftazidime, ceftriaxone, and cefepime were 94% (29/31), 94% (29/31) and 97% (30/31) respectively. The drug resistance rates of ampicillin, ampicillin-sulbactam and trimethoprim-sulfamethoxazole were 51% (16/31), 48% (15/31) and 48% (15/31) respectively, those of cefazolin, cefotetan, tobramycin, gentamicin and amikacinwere all 100% (31/31). There were no significant differences in the drug resistance rates of ceftazidime, ceftriaxone, aztreonam, ampicillin-sulbactam, ampicillin, trimethoprim-sulfamethoxazole and ciprofloxacin between the sepsis group and the non-sepsis group (χ2=0.31,0.31,0.00,0.02,0.02,0.02,0.26, all P>0.05). Conclusions: Invasive non-typhoid Salmonella infection in children at Xiamen mainly occurred in infants younger than 3 years old.The main clinical manifestations are fever, abdominal pain and diarrhea. C-reactive protein can be served as the laboratory indicators for indicating sepsis. The third generation of cephalosporins is recommended as the first choice for treatment.
Infant
;
Male
;
Female
;
Child
;
Humans
;
Child, Preschool
;
Anti-Bacterial Agents/therapeutic use*
;
Ceftriaxone/therapeutic use*
;
Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use*
;
Ceftazidime/therapeutic use*
;
Retrospective Studies
;
C-Reactive Protein
;
Drug Resistance, Bacterial
;
Salmonella Infections/microbiology*
;
Ampicillin/therapeutic use*
;
Salmonella
;
Diarrhea/drug therapy*
;
Bacteremia
;
Abdominal Pain
;
Microbial Sensitivity Tests
8.Spontaneous Bacterial Peritonitis with Sepsis Caused by Enterococcus hirae.
Jong Seop SIM ; Hyoung Su KIM ; Ki Jong OH ; Myung Soo PARK ; Eun Ju JUNG ; Youn Joo JUNG ; Dae Gil KANG ; Seung In SEO ; Won Jin KIM ; Myoung Kuk JANG
Journal of Korean Medical Science 2012;27(12):1598-1600
Selective intestinal decontamination (SID) with norfloxacin has been widely used for the prophylaxis of spontaneous bacterial peritonitis (SBP) because of a high recurrence rate and preventive effect of SID for SBP. However, it does select resistant gut flora and may lead to SBP caused by unusual pathogens such as quinolone-resistant gram-negative bacilli or gram-positive cocci. Enterococcus hirae is known to cause infections mainly in animals, but is rarely encountered in humans. We report the first case of SBP by E. hirae in a cirrhotic patient who have previously received an oral administration of norfloxacin against SBP caused by Klebsiella pneumoniae and presented in septic shock.
Administration, Oral
;
Ampicillin/therapeutic use
;
Anti-Bacterial Agents/therapeutic use
;
Ascitic Fluid/microbiology
;
Enterococcus/*isolation & purification
;
Gram-Positive Bacterial Infections/complications/drug therapy/*microbiology
;
Humans
;
Male
;
Microbial Sensitivity Tests
;
Middle Aged
;
Peritonitis/*diagnosis/drug therapy/microbiology
;
Sepsis/*etiology
9.The First Korean Case of Moraxella osloensis Bacteremia in a Patient with Acute Myeloid Leukemia.
Ji Yeon SUNG ; Sung Kuk HONG ; Eui Chong KIM
Annals of Laboratory Medicine 2014;34(3):256-258
No abstract available.
Aged
;
Ampicillin/therapeutic use
;
Anti-Bacterial Agents/therapeutic use
;
Antimetabolites, Antineoplastic/therapeutic use
;
Asian Continental Ancestry Group
;
Cytarabine/therapeutic use
;
Drug Therapy, Combination
;
Humans
;
Idarubicin/therapeutic use
;
Leukemia, Myeloid, Acute/complications/*diagnosis/drug therapy
;
Male
;
Moraxella/genetics/*isolation & purification
;
Moraxellaceae Infections/*diagnosis/drug therapy/microbiology
;
RNA, Ribosomal, 16S/chemistry/genetics
;
Republic of Korea
;
Respiratory Tract Infections/diagnosis/microbiology
;
Sequence Analysis, RNA
;
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
;
Sulbactam/therapeutic use
10.Recurrent group B streptococcal septicemia in a very low birth weight infant with infective endocarditis and submandibular cellulitis.
Annals of the Academy of Medicine, Singapore 2010;39(12):936-932
Ampicillin
;
pharmacology
;
therapeutic use
;
Cellulitis
;
drug therapy
;
prevention & control
;
Comorbidity
;
Endocarditis
;
drug therapy
;
prevention & control
;
Female
;
Humans
;
Infant
;
Infant, Low Birth Weight
;
Infant, Newborn
;
Recurrence
;
Sepsis
;
drug therapy
;
prevention & control
;
Streptococcal Infections
;
drug therapy
;
physiopathology
;
Streptococcus agalactiae
;
pathogenicity