The study was carried out on 18 healthy volunteers (9 men and 9 women), from 21 - 36 years old, all of them don’t be alcohol and smoke addiction. The result: in the experience condition, the plasma concentration of amoxcilin while using 1000mg tablet, 2 times/24 hours is higher than dose 500mg, 3 times/24 hours for both tablet and capsule. The treatment regimen based on 500mg tablet, 3 times/24 hours ensures more rapid absorption than on 500mg capsule, but it don’t change the bioavailable and the bioequivalence of drug
Biological Availability ; Amoxicillin ; Therapeutics

The bioavailability of amoxicilline for oral suspension was studied. The plasma concentrations of amoxicilline were measured by high pressure liquid chromatography (HPLC) using UV detector. The results of this study indicate that peak concentration (Cmax) of amoxicillin for oral suspension is 35.8 mcg/ml, time of peak concentration (tmax) is 1h and relative bioavailability is 137% and 169.5% comparing with capsules of Hamburg, pharmaceutical factory B, respectively.
Amoxicillin ; Pharmaceutical Preparations

The bioavailability of amoxiciline for oral suspension was determined using urinary excretion method. The average cumulative (mg) amoxiciline excreted after 24 hour for capsule (Hamburg), capsule (pharm.fac.B) and granule for suspension is 405.3mg, 341.2mg and 519.9mg, respectively.
Amoxicillin ; Pharmaceutical Preparations

No abstract available.
Amoxicillin ; Myasthenia Gravis

UV - spectrophotometric (UV) and high performance liquid chromatographic methods (HPLC) were described in determining amoxicillin and clavulanic acid in pharmaceutical preparations. Spectrophotometrically, amoxicillin was determined by measuring the absorbance values at 320 nm in buffer-CuS04 solution (pH 5.2) for amoxicillin and at 313 nm in imidazol solution (pH 6.8) for clavulanic acid. Beer's Law was obeyed in range 12 - 32mg. ml-1 for amoxicillin and 12 - 22 mg. ml-1 for clavulanic acid. The simultaneous HPLC method depended upon using a reserved phase RP18 column at ambient temperature with a mobile phase consisting of methanol - phosphate solution pH 4.4 (4:96) at a flow rate 1ml.min-1. Quantitation was achieved by UV detection at 220 nm. Calibration curve was linear over the concentration range 50-150 mg. ml-1 for amoxicillin and 15-35 mg. ml-1 for clavulanic acid. Both spectrophotometry and HPLC method showed good linear correlation, precision and accuracy. The obtained results from spectrophotometry and HPLC method showed no significant difference. Both methods were successfully applied to the assay of commercial tablets. The procedures were rapid, simple and suitable for quality control applications
Pharmaceutical Preparations ; Amoxicillin ; Clavulanic Acid

BACKGROUND: CLSI provides a guideline only for a agar dilution method of testing clarithromycin susceptibility for Helicobacter pylori. This study was to evaluate a disk diffusion method for clarithromycin and amoxicillin. METHODS: One hundred and forty clinical isolates of H. pylori isolated from May 2005 to May 2007 were tested by the CLSI agar dilution method and a disk diffusion method using 2microgram (2CLR) and 15microgram (15CLR) clarithromycin disks and 2microgram (2AMX) and 10microgram (10AMX) amoxicillin disks. The interpretation criteria used for the disk diffusion method were established by linear regression and error rate-bounded method for disk diffusion zone of inhibition (DDZ) compared to MIC. RESULTS: Resistance and intermediate rates to clarithromycin were 21.4% and 1.4%, respectively. A number of isolates with MIC 0.5, 1, and 2 (microgram/mL) to amoxicillin were 7, 2, and 1, respectively. For 2CLR and 15CLR, the coefficients of determination (R2) between MIC and DDZ were 0.931 and 0.923 (P< 0.001), respectively, and the criteria for resistance/ susceptibility were 12/28 mm for 2CLR and 23/39 mm for 15CLR. For 2AMX and 10AMX, the R2 between MIC and DDZ were 0.478 and 0.421 (P< 0.001), respectively, and the criteria for resistance with breakpoint of 2microgram/mL were 21 mm for 2AMX and 32 mm for 10AMX. All isolates had DDZ<60 mm with 2CLR and 2AMX, but 61.4% and 75.7% of the isolates had DDZ<60 mm with 15CLR and 10AMX, respectively. CONCLUSION: Excellent correlation and agreement between MIC and DDZ were found for clarithromycin and amoxicillin. With 2microgram disks, the susceptibility breakpoints were 28 mm or less; thus, two disks could be tested in one plate.
Agar ; Amoxicillin ; Clarithromycin ; Diffusion ; Helicobacter ; Helicobacter pylori ; Linear Models

A 12-year-old boy developed cholestatic hepatitis with Steven-Johnson syndrome following the use of amoxicillin. The skin lesion and general condition were improved over 2 weeks, but jaundice was gradually aggrevated. We performed liver biopsy, on 30th hospital day, which showed cholestatic hepatitis. The patient improved gradually and liver function was normalized 5 months later.
Amoxicillin ; Biopsy ; Child ; Hepatitis* ; Humans ; Jaundice ; Liver ; Male ; Skin

BACKGROUND/AIMS: To evaluate the adjuvant effects of N-acetylcysteine (NAC) on first-line sequential therapy (SQT) for Helicobacter pylori infection. METHODS: Patients with H. pylori infections were randomly assigned to receive sequential therapy with (SQT+NAC group, n=49) or without (SQT-only group, n=50) NAC. Sequential therapy consisted of rabeprazole 20 mg and amoxicillin 1 g for the first 5 days, followed by rabeprazole 20 mg, clarithromycin 500 mg and metronidazole 500 mg for the remaining 5 days; all drugs were administered twice daily. For the SQT+NAC group, NAC 400 mg bid was added for the first 5 days of sequential therapy. H. pylori eradication was evaluated 4 weeks after the completion of therapy. RESULTS: The eradication rates by intention-to-treat analysis were 58.0% in the SQT-only group and 67.3% in the SQT+NAC group (p=0.336). The eradication rates by per-protocol analysis were 70.0% in the SQT-only group and 80.5% in the SQT+NAC group (p=0.274). Compliance was very good in both groups (SQT only/SQT+NAC groups: 95.2%/100%, p=0.494). There was no significant difference in the adverse event rates between groups (SQT-only/SQT+NAC groups: 26.2%/26.8%, p=0.947). CONCLUSIONS: The H. pylori eradication rate was numerically higher in the SQT+NAC group than in the SQT-only group. As our data did not reach statistical significance, larger trials are warranted.
Acetylcysteine* ; Amoxicillin ; Clarithromycin ; Compliance ; Helicobacter pylori* ; Helicobacter* ; Humans ; Metronidazole ; Rabeprazole

Child; Amoxicillin; Pharmaceutical Preparations; risk factors; drugs; Phobic Disorders 90 children of 6-17 years old were divided into 3 groups: 30 children with phobia, 30 with phobia and general physical conditions, 30 in controlled group. The remarks are: physical illness, personality of children, family, school and social stress, overprotection of parents were various factors which increase the anxiety disorders and phobia
Child ; Amoxicillin ; Pharmaceutical Preparations ; risk factors ; drugs ; Phobic Disorders

BACKGROUND: Mutations in the p53 gene are the most frecjuent genetic alterations found in human cancers to date. Bvidense suggests that wild-type p53 is a tumor suppressor protein, crucial for the negative regulative of cell cycling, and requiring loss of function mutations for tumorigenesis. OBJECTIVE: Our purposr is to investigate the expression pattern of the p53 protein in the squamous cell carcinomas(SCCs) of the human skin. METHODS: We studied p53 protein expression, using DO7 mnoclonal antibody immunohi-stochemistry, in 29 SCCs of the skin. Also, we compared the p53 expression depending upon with or without a history of UV exposure. RESULTS: p53 immunoreactivity was observed in 48% (14 of 29) of SCCs and was not seen in normal skin. In 56% (16/29) SCCs the tumors were developed on UV-light exposure area. SCCs were divided on histopatal biological criteria in to three categories, well, moderately, or poorly differentiated. Although no significant differenie in the prevalence of p53 immunoreactivity was obierved between these groups, positive, strong staining was observed more frequently in poorly differentiated than in well-differe: treated tumors. CONCLUSION: Accumulat,i,on of p53 protein, suggestive in nessary cases of p53 gene mutation and hence loss of tumors upperesor function, may play a role in the tumorigenesis of SCCs.
Amoxicillin ; Carcinogenesis ; Carcinoma, Squamous Cell* ; Genes, p53 ; Humans* ; Prevalence ; Skin*