Introduction: According to the annual health report of Mongolia, non-communicable diseases are rising. Digestive system diseases, the second leading cause of morbidity in the population, account for an average of 15.5 percent of all morbidity over the last 10 years. In traditional Mongolian medicine, Plantago Major L has been widely used as a remedy for wound healing, cholangitis, gastric and duodenal ulcers. Material and method: The research was conducted in the pharmaceutical industry and technology laboratory. The leaves of Plantago Major L were chosen as the main raw materials and UV spectrophotometer, shaker, thin-layer chromatographic plates (Silica gel 60 F 254, Germany), and UV light were used in the experiment. The leaves of Plantago Major L were extracted with 40% ethyl alcohol in a soxlet apparatus and evaporated in a vacuum evaporator to obtain a thick extract. Result: Thin-layer chromatographic analysis of granule and ethyl alcohol extracts of Plantago Major L revealed yellow-brown spots (Rf = 0.4) at the same level as the standard substance rutin on the plate, indicating the presence of flavonoids. The highest light absorption was 250 nm when determining the sensitive wavelength of ethyl alcohol extract of Plantago Major L between 200 nm and 520 nm. The total flavonoids contained 3.95 ± 0.17% (p <0.001) in 40% ethyl alcohol extract of Plantago Major L. Conclusion It was detected that quantitative mass of total flavonoids in liquid extracts from was 3.95±0.17%.

Introduction: According to the annual health report of Mongolia, non-communicable diseases are rising. Digestive system diseases, the second leading cause of morbidity in the population, account for an average of 15.5 percent of all morbidity over the last 10 years. In traditional Mongolian medicine, Plantago Major L has been widely used as a remedy for wound healing, cholangitis, gastric and duodenal ulcers. Material and method: The research was conducted in the pharmaceutical industry and technology laboratory. The leaves of Plantago Major L were chosen as the main raw materials and UV spectrophotometer, shaker, thin-layer chromatographic plates (Silica gel 60 F 254, Germany), and UV light were used in the experiment. The leaves of Plantago Major L were extracted with 40% ethyl alcohol in a soxlet apparatus and evaporated in a vacuum evaporator to obtain a thick extract. Result: Thin-layer chromatographic analysis of granule and ethyl alcohol extracts of Plantago Major L revealed yellow-brown spots (Rf = 0.4) at the same level as the standard substance rutin on the plate, indicating the presence of flavonoids. The highest light absorption was 250 nm when determining the sensitive wavelength of ethyl alcohol extract of Plantago Major L between 200 nm and 520 nm. The total flavonoids contained 3.95 ± 0.17% (p <0.001) in 40% ethyl alcohol extract of Plantago Major L. Conclusion It was detected that quantitative mass of total flavonoids in liquid extracts from was 3.95±0.17%.

Introduction: Nowadays, there is a growing trend to use natural medicines with low side effects, and research on medicinal raw materials used in traditional medicine has become more widespread. Therefore, it is important to obtain a suitable drug form from Plantago Major L and to conduct chemical and pharmaceutical technology research. Material and method: The research was conducted in the pharmaceutical industry and technology laboratory. A granule formulation with several variants consisting of a concentrated extract and excipients was obtained. The sum of flavonoids of Plantago Major L extracts and Granular Dosage Forms was detected by thin-layer chromatography in a suitable solvent system prepared in the ratio of ethyl acetate, formic acid, glacial acetic acid, and water (100: 11:11:26). The total flavonoid content of the drug forms was determined by spectrophotometry. Result: Technological researches were carried out with lactose and glucose fillers, gelatin 8%, polyvinyl chloride (PVP) 6%, starch 5% binders, talc 1%, magnesium stearate 1% sliding and lubricating agents and the wet granulation method was used to obtain granules in several variants and was determined by using parameters such as particle spill weight and flow quality. In this research, the flow rate of Plantago Major L grains with lactose as a filler and PVP as a binder was -2.8 ± 0.18 g / sec (p <0.001) and the spill weight was -0.54 ± 0.03 g /cm3 (p <0.001). Based on the results of the above research, lactose was added as a filler, PVP as a binder, 6% as a slide and lubricant, 3% as talc and 1% as magnesium stearate, and the granular drug technology was developed by wet granulation. Analysis of the total flavonoids by thin-layer chromatography revealed the same level of yellow-brown spots (Rf = 0.4) on the plate. The total flavonoid content of the granules from Plantago Major L was 3.8 ± 0.2% (p <0.002). Conclusion In this study, a simple and suitable drug formulation from Plantago Major L was successfully obtained and it was a basic research to make new drug formulations in further needs.

BACKGROUND: In Ulaanbaatar, the first case of the pandemic influenza infection has been reported on 12 October 2010.By November 9, a total of 929 cases laboratory-confirmed had been reported to National Center for CommunicableDiseases (NCCD). Of these cases reported, 9 people died.METHODS: The objectives of the study were to describe patients who admitted and hospitalized at NCCD and to determineoverall attack rates among health workers, secondary attack rates among students of colleges and universities. Datawas analyzed using Epi-Info2000.RESULTS: Among 929 of laboratory-confirmed cases, 50.3% (95% CI 43.0-57.5) were males aged 23 (±14.9) in averagewith youngest – 7 months, oldest – 76 years old. Data analysis by districts among the hospitalized patients, showed32.8% (139) of total cases in Bayanzurkh district including the first case of the pandemic influenza infection. The majorityof patients who admitted and hospitalized to NCCD mostly experienced fever (288, 68.1%), dry cough (251, 59.3%),headache (203, 48.0%), sore throat (175, 41.6%). With 1020 physicians and health workers in total, 41.4% (422) ofthem work at NCCD, 35.4% (361) – at MCHRC. 11.1% of health workers out of total become ill with pandemic H1N12009 (overall attack rate 11.1%) with the most common symptom, 380C and higher fever (100.0%, 113), sore throat(83.2%, 94), cough (76.1%, 86) and runny nose (59.3%, 67). The higher attack rates of health workers by occupationwere doctor (18.0%) and auxiliary (13%). The secondary attack rates among university students for influenza-likeillness(ILI) were 12.9%. These secondary attack rates were higher among students of art’s college as compared withother universities (52.4%). For students, the main clinical symptoms were fever + sore throat (75.0%, 18), fever+ cough(70.8%, 17).DISCUSSION: In China, as of 27 September, 2009, from reported total 19981 cases infected with pandemic influenza,61.0% were males, mean age was 17, mainly affected with 83% school students that consistent with our study result.The similar results on clinical symptoms were obtained in Russia. Out of 130 patients, 28.6% had 380Ñ and higherfever, for 54.3% the body temperature reached 38.1-390Ñ where as 17.1% - higher 390Ñ and 96% had cough, 89%had muscle ache, 65% had headache, 14% had diarrhea.