1.Pregnancy rate and live birth rate from in vitro fertilization treatment
Khadbaatar R ; Khukhii S ; Bayartsogt Z ; Amarzaya L
Mongolian Medical Sciences 2016;176(2):15-18
BackgroundConducting IVF treatment in laboratory environment by using ARTechnologies in idiopathic infertility,which cannot be treated by both drug treatment and surgical treatment in Mongolia, and preparinglegal environment are the crucial issues in treating infertility. The study is theoretically and practicallysignificant to properly determine pregnancy rate and live birth rate after embryo transfer treatmentin Mongolia.GoalAim of the study is to determine pregnancy rate and live birth rate after IVF treatment in coupleshaving infertility problem.Objectives1. To determine pregnancy rate in conjunction with age factor after conducting In vitro fertilizationin laboratory environment in couples with infertility problem.2. To determine live birth rate after pregnancy in conjunction with age factor.Materials and MethodsThe information of 180 couples aged 22-46 y.o., who received IVF treatment in “Unimed International”hospital’s IVF Center between March 2014 and June 2015, has been used in this study. Pregnancyrate as well as live birth rate after in vitro fertilization treatment has been determined. Statistic datawere calculated by SPSS-20 and Microsoft office excel 2013.ResultsThe average age of 180 women treated by In vitro fertilization treatment was 35.21±5.1 y.o. Sortedby age group: aged ≤30 y.o. was 34 (18.8%), aged between 31-34 y.o. was 41 (22.7%), agedbetween 35-39 y.o. was 80 (44.4%) and aged ≥40 y.o. was 25 (13.8%). 71 (39.44%) of womentreated by In vitro fertilization became pregnant. Sorted by their age: aged ≤30 y.o. was 18 (52.9%),aged between 31-34 y.o. was 20 (48.7%), aged between 35-39 y.o. was 28 (35.0%) and aged ≥40y.o. was 5 (20.0%). Resulted live birth from pregnancy is 56 (78.8%). Sorted by their age: aged≤30 y.o. was 16 (88.8%), aged between 31-34 y.o. was 18 (90.0 %), aged between 35-39 y.o. was22 (78.5%) and aged ≥40 y.o. was 2 (40.0%). Multiple births from total live birth is 16 (28.57%),amongst them 14 (25.0%) were twin births and 2 (3.51%) of them had triplet birth.Conclusions:1. IVF treatment in laboratory environment by using ARTechnologies in idiopathic infertility, whichcannot be treated by both drug treatment and surgical treatment, have good results (averagepregnancy rate was 39.44%).2. Live birth rate from total pregnancy was 56 (78.8%).3. Multiple birth from total live birth is 16 (28.57%). 14 (25.0%) were twins and 2 (3.51%) weretriplets.4. The IVF success rate depends on variable factors such as maternal age, cause of infertility,embryo status, reproductive history and lifestyle factors.
2.The attack rates of the pandemic influenza infection, Ulaanbaatar, November 2009
Amarzaya S ; Altanchimeg S ; Suvd B ; Oyun M ; Enkhjargal T ; Tuul TS ; Dolgorkhand A ; Surenkhand G ; Ambeselmaa A
Mongolian Medical Sciences 2010;152(2):47-52
BACKGROUND: In Ulaanbaatar, the first case of the pandemic influenza infection has been reported on 12 October 2010.By November 9, a total of 929 cases laboratory-confirmed had been reported to National Center for CommunicableDiseases (NCCD). Of these cases reported, 9 people died.METHODS: The objectives of the study were to describe patients who admitted and hospitalized at NCCD and to determineoverall attack rates among health workers, secondary attack rates among students of colleges and universities. Datawas analyzed using Epi-Info2000.RESULTS: Among 929 of laboratory-confirmed cases, 50.3% (95% CI 43.0-57.5) were males aged 23 (±14.9) in averagewith youngest – 7 months, oldest – 76 years old. Data analysis by districts among the hospitalized patients, showed32.8% (139) of total cases in Bayanzurkh district including the first case of the pandemic influenza infection. The majorityof patients who admitted and hospitalized to NCCD mostly experienced fever (288, 68.1%), dry cough (251, 59.3%),headache (203, 48.0%), sore throat (175, 41.6%). With 1020 physicians and health workers in total, 41.4% (422) ofthem work at NCCD, 35.4% (361) – at MCHRC. 11.1% of health workers out of total become ill with pandemic H1N12009 (overall attack rate 11.1%) with the most common symptom, 380C and higher fever (100.0%, 113), sore throat(83.2%, 94), cough (76.1%, 86) and runny nose (59.3%, 67). The higher attack rates of health workers by occupationwere doctor (18.0%) and auxiliary (13%). The secondary attack rates among university students for influenza-likeillness(ILI) were 12.9%. These secondary attack rates were higher among students of art’s college as compared withother universities (52.4%). For students, the main clinical symptoms were fever + sore throat (75.0%, 18), fever+ cough(70.8%, 17).DISCUSSION: In China, as of 27 September, 2009, from reported total 19981 cases infected with pandemic influenza,61.0% were males, mean age was 17, mainly affected with 83% school students that consistent with our study result.The similar results on clinical symptoms were obtained in Russia. Out of 130 patients, 28.6% had 380Ñ and higherfever, for 54.3% the body temperature reached 38.1-390Ñ where as 17.1% - higher 390Ñ and 96% had cough, 89%had muscle ache, 65% had headache, 14% had diarrhea.
3.Technological study for preparing granule formulation from the concen trated extract of Plantago Major.L
Amarzaya Ts ; Tsetsegmaa S ; Chimedlkham B ; Tserendolgor B
Mongolian Pharmacy and Pharmacology 2022;21(2):5-9
Introduction:
Nowadays, there is a growing trend to use natural medicines with low side effects, and research on medicinal raw materials used in traditional medicine has become more widespread. Therefore, it is important to obtain a suitable drug form from Plantago Major L and to conduct chemical and pharmaceutical technology research.
Material and method:
The research was conducted in the pharmaceutical industry and technology laboratory. A granule formulation with several variants consisting of a concentrated extract and excipients was obtained. The sum of flavonoids of Plantago Major L extracts and Granular Dosage Forms was detected by thin-layer chromatography in a suitable solvent system prepared in the ratio of ethyl acetate, formic acid, glacial acetic acid, and water (100: 11:11:26). The total flavonoid content of the drug forms was determined by spectrophotometry.
Result:
Technological researches were carried out with lactose and glucose fillers, gelatin 8%, polyvinyl chloride (PVP) 6%, starch 5% binders, talc 1%, magnesium stearate 1% sliding and lubricating agents and the wet granulation method was used to obtain granules in several variants and was determined by using parameters such as particle spill weight and flow quality. In this research, the flow rate of Plantago Major L grains with lactose as a filler and PVP as a binder was -2.8 ± 0.18 g / sec (p <0.001) and the spill weight was -0.54 ± 0.03 g /cm3 (p <0.001). Based on the results of the above research, lactose was added as a filler, PVP as a binder, 6% as a slide and lubricant, 3% as talc and 1% as magnesium stearate, and the granular drug technology was developed by wet granulation. Analysis of the total flavonoids by thin-layer chromatography revealed the same level of yellow-brown spots (Rf = 0.4) on the plate. The total flavonoid content of the granules from Plantago Major L was 3.8 ± 0.2% (p <0.002).
Conclusion
In this study, a simple and suitable drug formulation from Plantago Major L was successfully obtained and it was a basic research to make new drug formulations in further needs.