No abstract available.
Alzheimer Disease*

No abstract available.
Alzheimer Disease*

Objective To investigate the relationship between neurofilament light chain protein （NfL） and clinical features in patients with Alzheimer disease. Methods We included 58 patients with Alzheimer's disease admitted to Ningbo No. 2 Hospital from June 2020 to December 2021. NfL levels were measured for the 58 patients with Alzheimer's disease. Correlation analysis was performed to study the correlation between NfL and age， disease course， hippocampal grade， Activities of Daily Living（ADL） score， Mini-Mental State Examination （MMSE） score， and Hasegawa Dementia Scale （HDS） score. The Pearson correlation coefficient （r） represented the strength of correlation. Results Among the 58 patients， 33 were females， with a mean NfL level of（24.93±17.07）pg/mL， and 24 were males， with a mean NfL level of 28.14 ± 17.98 pg/mL， which were not significantly different. NfL levels for different educational attainments had no significant difference： illiteracy （7/58），（27.87 ± 14.75）pg/mL；primary school（7/58），（15.22±9.62）pg/mL；middle school （14/58）， （27.95±15.60）pg/mL； high school（4/58），（12.84±2.97）pg/mL； technical secondary school（7/58）， （37.35±26.63）pg/mL； junior college （5/58），（33.79±21.81）pg/mL； and university （7/58），（15.22±9.62）pg/mL. NfL was positively correlated with age （r=0.448） and hippocampal grade（r=0.345）， and not significantly correlated with the course of disease（r=0.045，P>0.05）， ADL score （r=0.242，P>0.05），MMSE score （r=‒0.099，P>0.05），and HDS score （r=‒0.096，P>0.05）. Conclusion Serum NfL levels in patients with Alzheimer disease are positively correlated with age and hippocampal grade on magnetic resonance imaging， but not associated with sex， education attainments， the course of disease，ADL score，MMSE score，and HDS score.
Alzheimer Disease

Enlarged perivascular spaces（EPVSs）are one of the imaging biomarkers of cerebral small vessel disease（CSVD），and associated with other pathological changes of CSVD，worse cognitive function，and aging. This review describes the imaging characteristics and visual rating of EPVSs using magnetic resonance imaging and summarizes the research progress of EPVSs in Alzheimer disease in recent years in order to promote the understanding of this field.
Alzheimer Disease

Alzheimer disease（AD）， a degenerative disease of the central nervous system characterized by progressive cognitive dysfunction and behavioral impairment， has gradually become one of the most burdensome diseases in this century. At present， the amyloid cascade hypothesis is a widely recognized theory on the pathogenesis of AD. However， recent studies have shown that the immune system can play an important role in the occurrence of AD. This article summarizes the relationship between the immune system and the development and progression of AD from the existing literature， with an emphasis on the role of peripheral immunity in both the innate and adaptive immune systems， aiming to provide novel ideas for future research on AD in the immunological direction.
Alzheimer Disease

No abstract available.
Alzheimer Disease* ; Brain Injuries*

No abstract available.
Alzheimer Disease* ; Dementia*

No abstract available.
Alzheimer Disease ; Autopsy

No abstract available.
Alzheimer Disease* ; Neurons* ; Neuropeptides*

Most of the research activities on dementias have been and are focused on Alzheimer's disease. With regard to the treatment possibility and the cause and pathogenesis of cognitive impairment, however, non-Alzheimer dementias are also very important. We should extend our efforts to other dementing diseases than Alzheimer's disease.
Alzheimer Disease ; Cognition ; Dementia*