We investigated the immunogenicity of recombinant rMSP1 (rPbMSP1) that was generated from Plasmodium berghei. The rPbMSP1 formulated in alum was found to be immunogenic which induced high levels of specific anti-rPbMSP1 antibody. The IgG2a response predominated over IgG1 during the challenge infection in the vaccinated mice. Mice vaccinated with rPbMSP1 in alum mounted significant protective immunity against challenge infection (P < 0.01). On day 121 after the booster, three out of ten mice immunized with rPbMSP1 in PBS survived parasite infection (P < 0.05) and eight out of ten mice vaccinated with r MSP1 in alum did (P < 0.01). Hence, immunization with MSP1 in alum obviously has conferred protective effects, which prevented death from P. berghei lethal infection in mice (P < 0.01). These observations provide an excellent model for clinical assessment of this formulation in human subjects.
aluminum sulfate ; Laboratory mice ; upper case pea ; Infection as complication of medical care ; protect

The ability of aluminum potassium sulfate, locally known as "tawas" to induce pleurodesis in rabbits was determined by comparing its effects to talc. Both substances were transformed into a slurry and injected into the pleural cavity in the right hemithorax. The left pleural cavity served as control. After seven days, all five rabbits from each treatment group were sacrificed and the thoraces removed en bloc. Gross examination showed comparable adhesions. Microscopically, both groups showed marked thickening of the pleural connective tissue overlying the visceral and parietal pleura with persistent collections of alum or talc particles. There were no mortalities.

Animal ; Rabbits ; Talc ; Pleurodesis ; Aluminum Sulfate ; Pleural Cavity ; Pleura ; Alum Compounds ; Thorax ; Tissue Adhesions ; Bronchi ; Connective Tissue