Abstract: Ngo mtshar dga’ ston gter mdzod” by gelong (Fully ordained monk, Tib. དགེ་སློང་) Choijamts is one of the important medical books of traditional medicine. From this book, we found the Srog dzin-5 prescription and the purpose of the study is to determine acute and chronic toxicity of the prescription, and to identify its effect on animal models of depressive disorders. Methods:
1. The study was conducted using quantitative research method by experimental research model.
2. Determination of acute and chronic toxicity.
3. Chronic Unpredictable Mild Stress (CUMS) Procedure. Conclusion
1. Srog dzin-5 prescription (LD₅₀ = 25.8 (24-29) g/kg) has been shown to be non-toxic according to the generally accepted classification of K.Sidorov and B.Berezovskaya. When conducting histological studies, it was found that the surface of the liver, kidneys and adrenals is smooth. Color, shape and size of organs are normal.
2. In the model of chronic stress-induced depression, the Srog dzin-5 prescription increases physical activity, reduce tears, prevent anxiety and weight loss.

Abstract: There is a growing need for a systematic study of the use of medicines prepared from herbal, animal, and mineral raw materials in traditional Mongolian medicine to a new level. Based on traditional medicine technology and use, the study identified the most suitable modern medicinal ingredients for the human body, namely a medicine that can be used for depression in the ancient scripture, “Ngo mtshar dga’ ston gter mdzod” by Gelen Choijamts and further practical application is imperative. Purpose: To study the effects of Srog dzin-5 prescription on pathogenesis model of acute stress and animal models of depressive disor- ders. Conclusion
1. In the pathogenesis model of acute stress disorder caused by restricted mobility, Srog dzin-5 prescription prevents stress-induced thymic involution and enlargement of adrenal glands.
2. In the pathogenesis model of ethanol-induced depression, Srog dzin-5 prescription increased physical activity, reduced despair, and prevented anxiety according to behavioral assessment.

BACKGROUND: Acute cholecystitis is defi ned mostly as bacteria from intestinal infl ammation to gallbladder. Sometimes the inflammation can occur when bacteria and viral can fl ow by blood and lymphus. Acute cholecystitis is leading the second place of acute abdomen. (1.2.3.7.8). The acute cholecystitis complication is not decreasing(4.5.6). The mortality is 0.5-0.8%(2.4.5.9). The acute cholecystitis is comparing with cholelith. Foreign scientists are recommending that fi rst 24-48 hours to treat by drugs, and after that if infl ammation is not healing to do cholecystectomy. In our country the acute cholecystitis is taking the place after acute abdomen and appendicitis. And also, acute cholecystitis morbidity is not decreasing and indication of cholecystectomy is not decided yet. OBJECTIVE: The main purpose of this survey is to study changing of acute cholecystitis depending on time Materials and Methods We studied 58 patients who had cholecystectomy in Surgical Department of The Central Clinical Hospital for State Special Clerks between 2005 and 2008. The result analyzed by SPSS-15.0 Program. RESULT AND DISCUSSION: The patients who was studied were 14 men (24.14%) and 44 women (75.86%). For the clinical symptoms of acute cholecystitis, the result has been occurred as following: the epigastria pain is 17 (29.31±5.9), around the right rib arch is 49 (84.48±4.7), the pain spread of the right shoulder blade is 20 (34.48±6.2), and the pain spread of the right shoulder is 33 (56.89±6.5), to have a fever 6 (10.34±3.0), vomit 10 (17.24±4.9), diarrhea 7 (12.06±4.2), thirsty 16 (27.58±5.8). The pain around right rib arch, pain spread right arm and shoulder, and thirsty are the clinical features that close to the features of scientist’s Alperovich B.I., Soloviev M.M., Saveliev V.S. Acute cholecystitis depending on time 0-24 hours catarrhal 5, phlegmonous 2, necrosis 1, 24-48 hours phlegmonous 4, necrosis 10, necrosis hole 2, 48-72 hours phlegmonous 10, necrosis 8, necrosis hole 3, above 72 hours phlegmonous 2, necrosis 5, necrosis hole 6. Acute cholecystitis starts above 24 hours. CONCLUSION: 1. The acute cholecystitis has been occurred 14 for men and 44 for women. Ate the age of 30-39. These cases were determined more then 31 percent. 2. For the clinical symptoms of acute cholesystitis, the result has been occurred as following: - the epigastria pain is 17, (29.31±5.9) - around the right rib arch is 49 (84.48±4.7) - the pain spread of the right shoulder blade is 20 (34.48±6.2), and - the pain spread of the right shoulder is 33 (56.89±6.5). 3. Under the period study of the acute cholecystitis, the pus, necrosis and perforation cases have been excessively occurred specially at 48-72 hours. 4. Under the comparison study between the acute cholecystitis and its period, the acute wall cholecystitis changes have been occurred specially at 24-48 hours.

Background: Congenital heart disease (CHD) is the most common congenital disorders in the newborn and about 25% of them are complex heart diseases which needs early intervention or open heart surgery in neonate period. The incidence of CHD is varies from 8-10 in 1000 live births and half of them are major heart diseases. Abnormal ductusvenosus blood flow at 110-136 weeks has also been described in association with fetal aneuploidy, cardiac defects and adverse perinatal outcome. In the last few years the clinicians are using the nuchal translucency, ductus-venosus regurgitation in fetus as a biomarker of congenital heart disease. Objective: To assess the method of combining fetal nuchal translucency and ductusvenosus blood flow measurements in the detection of major cardiac defects in the first-trimester scan. Methods: Prospective cohort study data was derived from first-trimester screening of pregnant women at National Center for Maternal and Child Health between March 2014 and May 2017.
A total of 318 patients at 110 to 136 weeks of gestation enrolled in the study. An ultrasonography scan was performed trans abdominally (using 3 to 7.5 MHz curvilinear transducers),first, to determine gestational age from the measurement of the fetal crown-rump length; second, to measure fetal nuchal translucency thickness; and third, to assess blood flow across in the ductus-venosus. Results: During the study period, we carried out an ultrasonographic examination at 110-136 weeks in 318 singleton pregnancies with a live fetus and crown-rump length of 45-84 mm. The median age of women was 34 (range, 19-46 years). In our study 9(2,8%) of all singleton pregnancies were diagnosed with major heart defects and increased NT, ductus-venosus regurgitation was shown to be strongly associated with the CHD. The sensitivity of nuchal translucency to CHD was 83% (p-0.0001), dustus-venosus regurgitation was 75% (p-0.007), ductus-venosus PI was 80% (p-0.001). Conclusions First trimester biomarkers for fetal CHD screening can detect major heart defects. Increased NT, abnormal DV flow can be important indicators for echocardiography, which is favorablefor early prenatal diagnosis of CHD.