1.Isolation of alliin from Allium slltivllm L. in pilot scale
Journal of Medicinal Materials - Hanoi 2005;10(1):17-19
S-allylcysteine sulfoxide (alliin), a colouless and odorless solid, existed in intact garlic (Allium sativum L.) cloves. Alliin itself possessed no antibacterial activity, but it quickly converts into allicin, an antibacterial component by the enzyme alliinase, which naturally occurs in garlic. This paper reported an isolation method for alliin from garlic that was in pilot scale
Cysteine
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Allium
2.A New Steroidal Glycoside from Allium macrostemon Bunge
Yun Sik KIM ; Joon Min CHA ; Dong Hyun KIM ; Tae Hyun LEE ; Kang Ro LEE
Natural Product Sciences 2018;24(1):54-58
A phytochemical investigation of Allium macrostemon Bunge (Liliaceae) afforded the new pregnane steroidal glycoside, named allimacroside F (1), along with three known glycosides, benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (2), phenylethyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (3), (Z)-3-hexenyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (4). The identification and structural elucidation of a new compound (1) was carried out based on spectral data analyses (¹H-NMR, ¹³C-NMR, ¹H-¹H COSY, HSQC, HMBC, and NOESY) and HR-FAB-MS.
Allium
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Glycosides
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Liliaceae
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Statistics as Topic
3.Flower Pink Rot of Allium Plants Caused by Fusarium proliferatum.
Mycobiology 2001;29(4):224-226
Inflorescence of Allium thunbergii was found to be severely infected with Fusarium sp. The flower was covered with the fungus and eventually failed to form seeds. The causal fungus was identified as F. proliferatum (Matsushima) Nirenberg based on the cultural and morphological characteristics. Pathogenicity of the fungus was proved by artificial inoculation onto the healthy plants. This is the first record of this disease from Korea.
Allium*
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Flowers*
;
Fungi
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Fusarium*
;
Inflorescence
;
Korea
;
Virulence
4.Effects of Soils Containing Arbuscular Mycorrhizas on Plant Growth and Their Colonization.
Ahn Heum EOM ; Yee KIM ; Sang Sun LEE
Mycobiology 2002;30(1):18-21
Four arbuscular mycorrhizal fungal (AMF) inocula collected from three arable sites in Korea were used to determine plant growth, mycorrhizal root colonization rate and spore production in three different host plant species; Sorghum bicolor, Allium fistulosum, Tagetes patula. Growth of plant treated with AMF differed from those without AMF. Different AMF inocula showed significantly different root colonization rates and spore production of AMF on the wild plants, A. fistulosum and T. patula, but did not on the cultivated plant, S. bicolor. Results suggested that indigenous mycorrhizal fungal community would be important factors in mycorrhizal symbiosis, and play important roles in the plant succession.
Allium
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Colon*
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Korea
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Mycorrhizae*
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Plants*
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Soil*
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Sorghum
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Spores
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Symbiosis
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Tagetes
5.Allium Sativum-mediated Therapy for Experimental Prostate Cancers with In Vivo Tumor Transduction: Effects on Tumor Growth and Development.
Won Joon BHANG ; Jun CHEON ; Soon Chan KIM
Korean Journal of Urology 2001;42(6):663-667
PURPOSE: Allium sativum (AS) has been known to have widespread benefits in reducing some human cancer risk by immune stimualtion and anticarcinogenic activity. In the present study, we evaluated the preventive and antitumor properties of AS as an effective anticancer modifier for human prostate cancer in vivo. MATERIALS AND METHODS: Subcutaneous prostate cancers were established in athymic nude mice with 5x10(5) PC-3 human androgen-indenpendent prostate cancer cells. AS was injected at the site of tumor transplantation on day 1 and one week intervals up to 5 weeks (Experiment I), and into the established tumors sized by 50-60mm(3) weekly for 5 weeks (Experiment II). Therapeutic responses and efficacies of AS for prostate cancers in vivo were determined in separate controlled experiments, and definite histopathological studies were also performed. RESULTS: In vivo studies indicated statistically significant reduction in the incidence of tumor formation with programmed and continuous AS intralesional treatment. For established prostate cancer, AS treatment also demonstrated an inhibitory effect of tumor growth compared with control. Histomorphological and immunohistochemical studies demonstrated marked apoptosis after 5 weeks-AS continuous treatment in Experiment II. CONCLUSIONS: AS had a definite antitumor activity to inhibit tumorigenesis and may modulate tumor growth of prostate cancer in vivo. It is non-toxic, readily avaliable and inexpensive. AS, in the future, may be developed as a novel and effective treatment in chemoprevention for human prostate cancer.
Allium*
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Animals
;
Apoptosis
;
Carcinogenesis
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Chemoprevention
;
Garlic
;
Growth and Development*
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Humans
;
Incidence
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Mice
;
Mice, Nude
;
Prostate*
;
Prostatic Neoplasms*
6.Two Cases of Poisoning with Veratrum Maackii.
Won Young SUNG ; Yong Hwan KIM ; Jang Young LEE ; Gyeong Nam PARK ; Won Suk LEE ; Young Mo YANG
Journal of the Korean Society of Emergency Medicine 2012;23(5):738-741
Veratrum alkaloids in Veratrum maackii may cause significant gastrointestinal symptoms, bradycardia, hypotension, and arrythmia. We experienced successful outcomes in two patients who were victims of poisoning due to ingestion of Veratrum maackii, which was mistaken for Allium victorialis var. platyphyllum. One patient developed hypotension and prolongation of QT interval in electronicardiogram (ECG) and was treated with administration of vasopressor and magnesium. The other patient developed bradycardia and was treated with administration of atropine. Both patients were kept under close observation, and received supportive care, and both patients were discharged without any symptoms or complications.
Allium
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Arrhythmias, Cardiac
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Atropine
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Bradycardia
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Eating
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Humans
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Hypotension
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Magnesium
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Veratrum
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Veratrum Alkaloids
7.Advances in study of anticancer properties of Allii Macrostemonis Bulbus.
Quan-kui LAI ; Rui-lin TAO ; Yu-jia ZHAO ; Rui-fei ZI ; Quan HE
China Journal of Chinese Materia Medica 2015;40(24):4811-4816
A commonly used Chinese crude drug Allii Macrostemonis Bulbus has been shown to possess good anticancer activities and related properties such as antioxidation, nitrite scavenging, nitrosamine synthesis blocking and immune enhancement, and has been widely used as an effective auxiliary drug in the treatment of some malignant tumors. This paper systematically reviews the advances in the study of anticancer-related activities of Allii Macrostemonis Bulbus's various components such as raw juice, extracts, saponins, volatile oil, polysaccharides, nitrogen compounds, etc.
Allium
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chemistry
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Animals
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Antineoplastic Agents, Phytogenic
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pharmacology
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Antioxidants
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pharmacology
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Humans
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Oils, Volatile
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pharmacology
;
Plant Extracts
;
pharmacology
8.Characterization and Pathogenicity of Alternaria vanuatuensis, a New Record from Allium Plants in Korea and China.
Mei Jia LI ; Jian Xin DENG ; Narayan Chandra PAUL ; Hyang Burm LEE ; Seung Hun YU
Mycobiology 2014;42(4):412-415
Alternaria from different Allium plants was characterized by multilocus sequence analysis. Based on sequences of the beta-tubulin (BT2b), the Alternaria allergen a1 (Alt a1), and the RNA polymerase II second largest subunit (RPB2) genes and phylogenetic data analysis, isolates were divided into two groups. The two groups were identical to representative isolates of A. porri (EGS48-147) and A. vanuatuensis (EGS45-018). The conidial characteristics and pathogenicity of A. vanuatuensis also well supported the molecular characteristics. This is the first record of A. vanuatuensis E. G. Simmons & C. F. Hill from Korea and China.
Allium*
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Alternaria*
;
China*
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Korea
;
Multilocus Sequence Typing
;
Phylogeny
;
RNA Polymerase II
;
Statistics as Topic
;
Tubulin
;
Virulence*
9.Occurrence of Sclerotium Rot in Allium tuberosum Caused by Sclerotium rolfsii in Korea.
Jin Hyeuk KWON ; Dong Wan KANG ; Won Doo SONG ; Okhee CHOI
Mycobiology 2011;39(3):230-232
In this study, we characterized sporadically occurring sclerotium rot caused by Sclerotium rolfsii in Chinese chive (Allium tuberosum Roth.) in farm fields in Sacheon, Korea. The initial symptom of the disease was water-soaked, which progressed to rotting, wilting, blighting, and eventually death. Further, mycelial mats spread over the lesions near the soil line, and sclerotia formed on the scaly stem and leaves. The sclerotia were globoid, 1~3 mm, and white to brown. The optimum temperature for growth and sclerotia formation on potato dextrose agar (PDA) was 30degrees C. The diameter of the hypae ranged from 4 to 8 microm. Clamp connection was observed on PDA medium after 5 days of incubation. Based on the mycological characteristics, internal transcribed spacer sequence analysis, and pathogenicity test, the causal agent was identified as Sclerotium rolfsii Saccardo. This is the first report of sclerotium rot in Chinese chive caused by S. rolfsii in Korea.
Agar
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Allium
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Allyl Compounds
;
Chive
;
Glucose
;
Humans
;
Korea
;
Sequence Analysis
;
Soil
;
Solanum tuberosum
;
Sulfides
10.Phytochemistry and pharmacology of Allii Macrostemonis Bulbus, a traditional Chinese medicine.
Zhi-Hong YAO ; Zi-Fei QIN ; Yi DAI ; Xin-Sheng YAO
Chinese Journal of Natural Medicines (English Ed.) 2016;14(7):481-498
Allii Macrostemonis Bulbus (Xiebai in Chinese), as a famous traditional Chinese medicine, has great medicinal and dietary values since ancient times. In China, the dry bulbs of Allium macrostemon and Allium chinense are both used as its original plants. Pharmacological studies have revealed that both of them could increase plasminogen activator activity and prolong the effect of coagulation to achieve antiplatelet aggregation which validates their traditional uses for the treatment of thoracic obstruction and cardialgia in clinics. Besides, several other significant activities, including lipid-lowering, anti-atherosclerosis, antitumor, antispasmodic, antibacterial, antioxidant, and insecticidal activities, have already been reported. The volatile oils, nitrogenous compounds, and steroidal saponins are the major beneficial compounds. Among them, steroidal saponins are considered as the characteristic constituents. In this review, the current information concerning the phytochemistry and pharmacology of Allii Macrostemonis Bulbus is summarized comprehensively. In addition, several research future perspectives are presented, especially the mechanism of bioactive components and fraction from the bulbs of Allium macrostemon and Allium chinense.
Allium
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chemistry
;
Animals
;
Drugs, Chinese Herbal
;
chemistry
;
pharmacology
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Humans
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Plant Roots
;
chemistry
;
Structure-Activity Relationship