OBJECTIVETo study the effect of the S-bioallethrin on human lymphocytes by microarray technique.

METHODSThe changes of normal human lymphocytes treated with S-bioallethrin were examined with light microscope, flow cytometry, electron microscope, DNA ladder and microarray techniques.

RESULTSMorphological study showed that the lymphocytes underwent apoptosis after S-bioallethrin exposure, which as further confirmed by the expression changes of 346 genes.

CONCLUSIONS-bioallethrin can induce apoptosis of normal human lymphocytes and changes in their gene expression profiles.

Allethrin ; pharmacology ; Apoptosis ; drug effects ; Flow Cytometry ; Gene Expression Profiling ; Humans ; Insecticides ; pharmacology ; Lymphocytes ; drug effects ; metabolism ; ultrastructure ; Microscopy, Electron ; Oligonucleotide Array Sequence Analysis ; Reverse Transcriptase Polymerase Chain Reaction