1.Registry of infl ammatory demyelinating diseases of the central nervous system in the Asia-Pacifi c region
Qi Cheng ; Allan G. Kermode ; Bhim Singhal ; Kwang Ho Lee ; Victor HT Chong ; Nguyen Thanh Binh ; Ching-Piao Tsai ; Jusuf Misbach ; Guo-Xin Jiang ; Sten Fredrikson
Neurology Asia 2012;17(1):49-54
Background and Objective: Comparable data are sparse for infl ammatory demyelinating diseases of
the central nervous system (CNS) in the Asia-Pacifi c region, and we aimed to establish a registry
of patients with such diseases in the region. Methods: A network of neurologists in the Asia-Pacifi c
Region was established to register patients with the targeted diseases. A standardized register form and
relevant instructions in English, translated into the local language when needed, were prepared before
the study start and used for data collection. Results: Eight study centres from different countries/areas
participated in the study. In total, 857 patients with a validated diagnosis of different infl ammatory
demyelinating diseases of the CNS were registered, 591 females and 266 males with a female-to-male
ratio 2.2. The mean age at onset for all patients was 35.9 (SD: 12.9) years, signifi cantly younger (p =
0.010) for females (35.1 years, SD: 12.6 years) than for males (37.6 years, SD: 13.4 years).
Conclusion: Patients with different infl ammatory demyelinating diseases of the CNS were in the fi rst
time registered in a multi-centre study from eight countries/areas in the Asia-Pacifi c region. A platform
and basis has been established for further study in the fi eld.
2.Magnetic resonance imaging manifestations of cerebral small vessel disease: automated quantification and clinical application.
Lei ZHAO ; Allan LEE ; Yu-Hua FAN ; Vincent C T MOK ; Lin SHI
Chinese Medical Journal 2020;134(2):151-160
The common cerebral small vessel disease (CSVD) neuroimaging features visible on conventional structural magnetic resonance imaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. The CSVD neuroimaging features have shared and distinct clinical consequences, and the automatic quantification methods for these features are increasingly used in research and clinical settings. This review article explores the recent progress in CSVD neuroimaging feature quantification and provides an overview of the clinical consequences of these CSVD features as well as the possibilities of using these features as endpoints in clinical trials. The added value of CSVD neuroimaging quantification is also discussed for researches focused on the mechanism of CSVD and the prognosis in subjects with CSVD.
Cerebral Small Vessel Diseases/diagnostic imaging*
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Humans
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Magnetic Resonance Imaging
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Neuroimaging
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Prognosis