No abstract available.
Acidosis, Respiratory* ; Alkalosis, Respiratory*

No abstract available.
Alkalosis ; Humans ; Hypokalemia

No abstract available.
Alkalosis ; Gastrostomy ; Renal Dialysis

This cross-sectional study involved 339 students aged 12-15 at Sapa and Yen Binh regions. It measured and compared indexes such as vital capacity (VC), forced expiratory volume 1 (FEV1), and Tiffeneau index. Results: there weren’t significant differences between VC, FEV1 and Tiffeneau indexes of students in both sexes of 2 regions (p<0.05). There is a close correlation between VC and height of student (r>0.9), and between FEV1 and height (r>0.9)
Preventive Medicine ; Public Health ; Alkalosis, Respiratory

BACKGROUND: Rapid and accurate diagnosis of multiple acid-base disorders is not so easy. The authors evaluated a need of a computer-aided diagnosis program for acid-base disorders through the questions of 25 cases with acid-base disorders in 105 physicians. METHODS: For 39 college graduated students and 66 housestaffs, we asked them to diagnose 25 sample cases of acid-base disorders, which were selected from the published 36 cases (Horn et. al. 1992, Halperin and Goldstein 1994, Walmsley and White 1988). The 25 questions consisted of 15 cases with single disorder, 8 cases with double disorder and 2 cases with triple disorder. RESULTS: The 39 college graduated students diagnosed correctly in 55.4%; 79.6% in single disorders, 23.7% in double disorders and 0.0% in triple disorders. The 36 housestaffs (answer rate: 55.4%) diagnosed correctly in 61.7%; 82.4% in single disorders, 38.2% in double disorders and 0.0% in triple disorders. CONCLUSIONS: The data suggest that the physicians can't diagnose acid-base disorders well and that they needs a computer-aided expert system to diagnose the acid-base disorders and to ensure uniform quality of patient care.
Acidosis ; Alkalosis ; Diagnosis* ; Expert Systems* ; Humans ; Patient Care

The objective was to compare the two procedures of treatment for hypocalcemia in acute respiratory alkalosis performed by rebreathing into a small paper bag with that of the IV calcium replacement therapy. 25 patients with clinical manifestations of hypocalcemia admitted to the Department of Emergency, Cho Ray Hospital were prospectively included in this study. Patients were divided into two groups according to the time of day they visited the emergency department. Group I was treated by IV calcium replacement. Group II was treated rebreathing into a small paper bag without drug. In conclusion, group I had 3.80.8 minute and group II had 4.41.17 minute to disappear the manifestations of hypocalcemia. The average statistical test between these two groups in this study has shown that the two procedures were not different statistical significance
Alkalosis, Respiratory ; Respiratory Distress Syndrome, Adult ; Hypocalcemia ; Therapeutics

Primary Aldosteronism is characterized by hypertension, hypokalemic alkalosis and increased aldosterone secretion. It is important to distinguish between adenoma and hyperplasia for the treatment of primary aldosteronism because the hypertension associated with the adenomatous form is more likely to respond to operative removal. We report a case of aldosterone producing adrenal adenoma which was diagnosed by postural stimulation test of aldosterone and abdominal computed tomography, and was treated by adrenalectomy. A week after surgery, the blood pressure and laboratory data returned to normal.
Adenoma ; Adrenalectomy ; Aldosterone ; Alkalosis ; Blood Pressure ; Hyperaldosteronism ; Hyperplasia ; Hypertension

Renal ammonia metabolism is the predominant component of net acid excretion and new bicarbonate generation. Renal ammonia metabolism is regulated by acid-base balance. Both acute and chronic acid loads enhance ammonia production in the proximal tubule and secretion into the urine. In contrast, alkalosis reduces ammoniagenesis. Hypokalemia is a common electrolyte disorder that significantly increases renal ammonia production and excretion, despite causing metabolic alkalosis. Although the net effects of hypokalemia are similar to metabolic acidosis, molecular mechanisms of renal ammonia production and transport have not been well understood. This mini review summarizes recent findings regarding renal ammonia metabolism in response to chronic hypokalemia.
Acid-Base Equilibrium ; Acidosis ; Alkalosis ; Ammonia ; Hypokalemia ; Kidney

Action of neuromuscular blocking agents are known to be largely affected by acid-base imbalance. In general, acidosis potentiates and alkalosis antagonizes the action of the neuromuscular blockers. To evaJuate the effects of acid-base imbalance on the neuromuscular actions of atracurium or vecuronium in 24 cats, we induced respiratory and metabolic acid-base imbalance and performed cumulative dose response studies. The results are as follows; 1) ED(50) and ED(95) of the atracurium was smaller in metabolic acidosis than those of respiratory and metabolic alkalosis. 2) ED(50) of vecuronium was not affected by acid-base imbalance in either agent. 3) Duration and recovery index were not affected by acid-base imbalance in either agent. 4) In atracurium group, serum potassium and calcium values during respiratory or metabolic alkalosis were smaller than those of control, but did not influence the neuromuscular action of atracurium. 5) Dose-response curve of the atracurium shifted to the right with metabolic acidosis, respiratory acidosis, metabolic alkalosis and respiratory alkalosis in order, but acid-base imbalance did not influence the dose-response curve of the vecuronium. In conclusion, the potency might be increased in respiratory and metabolic acidosis with atracurium, but not with vecuronium. However, action and recovery were not influenced by a experimental imbalance in either agent.
Acid-Base Imbalance ; Acidosis ; Acidosis, Respiratory ; Alkalosis ; Alkalosis, Respiratory ; Animals ; Atracurium* ; Calcium ; Cats ; Neuromuscular Blockade* ; Neuromuscular Blocking Agents ; Potassium ; Vecuronium Bromide*

Pendrin (SLC26A4) is a Na+-independent Cl-/HCO3- exchanger which is expressed in the apical membranes of type B and non-A, non-B intercalated cells within the distal convoluted tubule, the connecting tubule, and the cortical collecting duct. In those segments it mediates HCO3- secretion and chloride (Cl-) absorption. In mice, no renal abnormalities are observed under basal conditions, and individuals with genetic disruption of the pendrin (SLC26A4) gene (Pendred syndrome) have normal acid-base balance. In contrast, there are definite differences under conditions wherein the transporter is stimulated. In animal studies, pendrin (SLC26A4) is upregulated with aldosterone analogues, Cl- restriction, and metabolic alkalosis, and is down-regulated with Cl loading and metabolic acidosis, independently. However, the exact role of pendrin in humans has not been established to date, and further examinations are necessary.
Absorption ; Acid-Base Equilibrium ; Acidosis ; Acidosis, Renal Tubular ; Aldosterone ; Alkalosis ; Animals ; Humans ; Membranes ; Mice