【Objective】 To compare the safety, efficacy, and patient satisfaction of conventional percutaneous nephrolithotomy (PCNL) and PCNL with integrated ureteric renal catheter in the treatment of kidney stones, so as to provide reference for the clinical application of this method. 【Methods】 A retrospective analysis were conducted on 154 patients with kidney stones (stone diameter 1.5—3.5 cm) admitted to our hospital during Apr.2022 and May 2023.Based on the method of placing the double-J stent and nephrostomy tube after stone fragmentation, the patients were divided into the integrated group (using PCNL with integrated ureteric renal catheter,n=77) and the standard group (conventional PCNL technique,n=77).The general characteristics, preoperative, postoperative, and follow-up data were compared between the two groups. 【Results】 There were no significant differences in postoperative hospital stay \[ (5.78±2.50) d vs. (5.29±2.18) d, P=0.193] , postoperative pain score \[ (2.22±0.42) vs. (2.30±0.46) , P=0.273\], preoperative-postoperative change in hemoglobin \[ (-4.13±10.11) g/L vs. (-2.96±9.39) g/L, P=0.459\], hospitalization costs \[ (17 088.14±2 876.94) yuan vs. (16 389.74±2 427.37) yuan, P=0.105\], and stone clearance rate \[65 (84.4.6%) vs.66 (85.7%) , P=0.821\] between the two groups (P>0.05).The integrated group had significantly lower incidence of post-discharge discomfort symptoms than the standard group \[36.4% (28/77) vs. 90.9% (70/77), P=0.001\].The integrated group reported higher satisfaction (77 satisfied vs. 64 satisfied plus 13 basically satisfied).No postoperative sepsis, septic shock, or transfer to the intensive care unit occurred. 【Conclusion】 PCNL with integrated ureteric renal catheter and conventional PCNL demonstrate comparable safety and efficacy, but the integrated method yields higher satisfaction, suggesting its worthiness for clinical promotion and application under appropriate indications.