1.Effects of postoperative parenteral nutrition with different lipid emulsions in patients undergoing major abdominal surgery.
Seher DEMIRER ; Ali SAPMAZ ; Ahmet Serdar KARACA ; Ilknur KEPENEKCI ; Semih AYDINTUG ; Deniz BALCI ; Pinar SONYUREK ; Kenan KOSE
Annals of Surgical Treatment and Research 2016;91(6):309-315
PURPOSE: This study was designed to investigate the effects of total parenteral nutrition (PN) using different lipid emulsions in patients undergoing major abdominal surgery. METHODS: Fifty-two patients were randomized to receive soybean oil + medium chain triglycerides (MCT) (group I), soybean oil + olive oil (group II), soybean oil + olive oil + fish oil (group III) as a lipid source. PN was started on postoperative day 1 and patients were maintained on PN for a minimum period of 4 days. Laboratory variables (CRP, prealbumin, transferrin) were measured before surgery and on postoperative days. RESULTS: Three treatment groups were included in the study. Patients in group I received long chain triglycerides (LCT) + LCT/MCT emulsion (%75 LCT + %25 LCT/MCT); Patients in group II received olive oil based emulsion (80% olive oil + 20% soybean oil, ClinOleic); Patients in group III received fish oil in addition to olive oil based emulsion (%85 ClinOleic + %15 Omegaven; Fresenius Kabi). The following 14 parameters were assessed: body weight, CRP, prealbumin, transferrin, tumor necrosis factor-α, interleukin-6, total antioxidant status, thiobarbituric acid reactive substances, oxidized low density lipoprotein-2, complete blood cell, international normalized ratio, D-dimer, activated partially thromboplastin time, prothrombin time. All other parameters showed no differences among the groups. CONCLUSION: The results of our trial demonstrate a potential beneficial effect of soybean oil/olive oil based lipid emulsions for use in PN regarding inflammatory response and oxidant capacity in the treatment of patients.
Blood Cells
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Body Weight
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Emulsions*
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Fish Oils
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Humans
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Interleukin-6
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International Normalized Ratio
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Necrosis
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Olive Oil
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Parenteral Nutrition*
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Parenteral Nutrition, Total
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Prealbumin
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Prothrombin Time
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Soybean Oil
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Soybeans
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Thiobarbituric Acid Reactive Substances
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Thromboplastin
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Transferrin
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Triglycerides