1.Doxorubicin Cardiotoxicity: Response of Left Ventricular Ejection Fraction to Exercise and Incidence of Regional Wall Motion Abnormalities.
Jong Hoa BAE ; Markus SCHWAIGER ; Alexander LIN ; Mark MANDELKERN ; Heinrich R SCHELBERT
Korean Circulation Journal 1985;15(1):13-26
No abstract available.
Doxorubicin*
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Incidence*
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Stroke Volume*
2.Mechanism and cLinicaL characteristics in diagnosis and treatment of amniotic fluid emboLism
Alexander LIN ; Ye FENG ; Yun LU ; Huixia YANG ; Lingqun HU
Chinese Journal of Perinatal Medicine 2019;22(4):220-222
Amniotic fluid embolism(AFE) is a fatal intrapartum complication. Typical AFE is characterized by respiratory and circulatory failure, followed by disseminated intravascular coagulation(DIC), while atypical AFE, which had a higher survival possibility, presents with unexplained DIC only. Recent findings support an anaphylactoid inflammatory mechanism underlying the pathophysiology of AFE. Milrinone is currently the first choice for AFE due to its several functions, such as reducing pulmonary artery pressure, and improving right ventricular function through lowering heart rate and positive inotropic action. A multidisciplinary team is required in the rescue of AFE and medical staff who are skilled in critical medicine (such as anesthesiologists) often play a pivotal role.
3.Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity
Po-Han CHOU ; Yen-Feng LIN ; Ming-Kuei LU ; Hsin-An CHANG ; Che-Sheng CHU ; Wei Hung CHANG ; Taishiro KISHIMOTO ; Alexander T. SACK ; Kuan-Pin SU
Clinical Psychopharmacology and Neuroscience 2021;19(2):190-205
Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. However, although various TMS protocols have been proven to be clinically effective, the response rate varies across clinical applications due to the heterogeneity of real-world psychiatric comorbidities, such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or substance use disorder, which are often observed in patients with MDD. Therefore, individualized treatment approaches are important to increase treatment response by assigning a given patient to the most optimal TMS treatment protocol based on his or her individual profile. This literature review summarizes different rTMS or TBS protocols that have been applied in researches investigating MDD patients with certain psychiatric comorbidities and discusses biomarkers that may be used to predict rTMS treatment response. Furthermore, we highlight the need for the validation of neuroimaging and electrophysiological biomarkers associated with rTMS treatment responses. Finally, we discuss on which directions future efforts should focus for developing the personalization of the treatment of depression with rTMS or iTBS.
4.Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity
Po-Han CHOU ; Yen-Feng LIN ; Ming-Kuei LU ; Hsin-An CHANG ; Che-Sheng CHU ; Wei Hung CHANG ; Taishiro KISHIMOTO ; Alexander T. SACK ; Kuan-Pin SU
Clinical Psychopharmacology and Neuroscience 2021;19(2):190-205
Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) are evidenced-based treatments for patients with major depressive disorder (MDD) who fail to respond to standard first-line therapies. However, although various TMS protocols have been proven to be clinically effective, the response rate varies across clinical applications due to the heterogeneity of real-world psychiatric comorbidities, such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, or substance use disorder, which are often observed in patients with MDD. Therefore, individualized treatment approaches are important to increase treatment response by assigning a given patient to the most optimal TMS treatment protocol based on his or her individual profile. This literature review summarizes different rTMS or TBS protocols that have been applied in researches investigating MDD patients with certain psychiatric comorbidities and discusses biomarkers that may be used to predict rTMS treatment response. Furthermore, we highlight the need for the validation of neuroimaging and electrophysiological biomarkers associated with rTMS treatment responses. Finally, we discuss on which directions future efforts should focus for developing the personalization of the treatment of depression with rTMS or iTBS.
5.Pandemic of the aging society - sporadic cerebral small vessel disease.
Alexander Yuk Lun LAU ; Bonaventure Yiu Ming IP ; Ho KO ; Bonnie Yin Ka LAM ; Lin SHI ; Karen Ka Yan MA ; Lisa Wing Chi AU ; Yannie Oi Yan SOO ; Thomas Wai Hong LEUNG ; Adrian WONG ; Vincent Chung Tong MOK
Chinese Medical Journal 2021;134(2):143-150
Age-related sporadic cerebral small vessel disease (CSVD) has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population. The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers' understanding in the in vivo evolution of CSVD, its impact upon the brain, its risk factors, and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD. In this review, we aimed to provide an update on the pathophysiology, risk factors, biomarkers, and the determinants and spectrum of the clinical manifestation of sporadic CSVD.
Aged
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Aging
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Brain/diagnostic imaging*
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Cerebral Small Vessel Diseases/epidemiology*
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Humans
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Magnetic Resonance Imaging
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Pandemics