No abstract available.
Aldosterone* ; Humans* ; Prolactin*

No abstract available.
Aldosterone* ; Humans ; Hyperaldosteronism*

Discoveries of somatic mutations permit the recognition of subtypes of aldosterone-producing adenomas (APAs) with distinct clinical presentations and pathological features. Catenin β1 (CTNNB1) mutation in APAs has been recently described and discussed in the literature. However, significant knowledge gaps still remain regarding the prevalence, clinical characteristics, pathophysiology, and outcomes in APA patients harboring CTNNB1 mutations. Aberrant activation of the Wnt/β-catenin signaling pathway will further modulate tumorigenesis. We also discuss the recent knowledge of CTNNB1 mutation in adrenal adenomas.
Adenoma* ; Aldosterone* ; Carcinogenesis ; Humans ; Prevalence

No abstract available.
Aldosterone* ; Child* ; Humans ; Nephrosis, Lipoid*

Humans ; Hyperaldosteronism/therapy* ; Aldosterone ; Hypertension

Humans ; Hyperaldosteronism/therapy* ; Aldosterone ; Hypertension

In most cases, primary aldosteronism is due to a unilateral adrenal adenoma or bilateral hyperplasia of the adrenal cortex. However, a few bilateral adrenal tumors have also been reported in primary aldosteronism. In such cases, it is important to differentiate bilateral aldosterone-producing adenomas from bilateral adrenal hyperplasia so as to develop the optimal treatment plan. We report a case of idiopathic hyperaldosteronism due to bilateral adrenal hyperplasia that could have been misdiagnosed as a bilateral aldosterone-producing adenoma. An adrenal CT scan revealed bilateral adrenal tumors (1.5 cm [right] and 3.6 cm [left] in diameter). Idiopathic hyperaldosteronism was properly diagnosed using a posture test and selective adrenal venous sampling.
Adenoma ; Adrenal Cortex ; Aldosterone ; Hyperaldosteronism ; Hyperplasia ; Posture

BACKGROUND/AIMS: Transtubular potassium gradient(TTKG) is known as the most accurate indicator of aldosterone activity. TTKG may be used to monitor the effectiveness of aldosterone antagonist which is prescribed generally for the management of cirrhotic ascites. Spot urine [Na]/[K] ratio may also be used for the same purpose. METHODS: After measuring TTKG, spot urine [Na]/[K] ratio, and plasma aldosterone concentration in each of the 23 patients all who had cirrhotic ascites, 100 mg of spiron-olactone was prescribed to be taken daily for 5 days. When no diuretic response occurred and TTKG was more than 3.5 at the end of 5 days, the dose of spironolactone was increased by 100 mg/day at the interval of 5 days until TTKG decreased to below 3.5. Furosemide was added to the non-responders if their TTKG had dropped to below 3.5. RESULTS: Basal plasma concentration of aldosterone was higher than upper normal limit in 13(57%) patients, and correlated with TTKG significantly(r=0.60, p=0.002). TTKG was calculated to be 3.5+/-0.67 when assuming the aldosterone activity has been completely blocked. Spot urine [Na]/[K] ratio had significant negative correlation with TTKG before and after the administration of spironolactone. In most patients, diuretic response appeared with the fall of TTKG (especially below 3.5) and with the rise of spot urine [Na]/[K] ratio. In patients who did not respond to a low dose spironolactone, further treatment plan (to increase dose of spironolactone or to add furosemide) was guided by TTKG, and all were successful. CONCLUSIONS: TTKG and spot urine [Na]/[K] ratio are good indicators of aldosterone activity, and might be used as useful guidelines in the diuretic management of cirrhotic ascites.
Aldosterone ; Ascites* ; Furosemide ; Humans ; Plasma ; Potassium* ; Spironolactone

This study was performed to investigate the effects of nitrous oxide-narcotic anesthesia (Nitrous oxide-pethidine HCI-muscle relaxant) and surgery on plasma aldosterons level in surgical patients and the aldosterone level in plasma was measured by the Abbott Laboratorie's Aldosterone RIA Kit. Average body weights and ages of subjects were 58.1+/-6.45(kg) and 43.8+/-11.55(yrs) respectively. Mean control aldosterone level in plasma was 121.3+/-58.66I(pg/ml) (mean +/- SE) but it gradually rose during anesthesia and surgery. The mean plasma aldosterone level rose to 232.7+/-40.06(pg/ml) (p<0.005) at 90 minutes after the start of surgery, and therefore, it was a significantly higher value than that of the control.
Aldosterone* ; Anesthesia* ; Body Weight ; Humans ; Plasma*

No abstract available.
Aldosterone ; Insulin Resistance ; Insulin ; Negotiating ; Obesity