OBJECTIVE: To research the relation between blood alcohol concentration (BAC) and neurobehavioral function after drinking. METHODS: The neurobehavioral ability index (NAI) of 233 volunteers were measured with computer-administered neurobehavioral evaluation system-Chinese3 (NES-C3). RESULTS: The NAI of simple visual reaction time and mental arithmetic declined when BAC was more than 0.157 mg/mL, the NAI of benton visual retention, length discrimination and digit cancel declined significantly when BAC was more than 0.204 mg/mL. CONCLUSION The neurobehavioral function declined significantly when BAC increased and recovered gradually when BAC declined due to the elimination of alcohol in blood.
Adult ; Alcohol Drinking/adverse effects* ; Alcohol-Induced Disorders, Nervous System/blood* ; Ethanol/blood* ; Female ; Forensic Toxicology ; Humans ; Male ; Middle Aged ; Young Adult

Recent studies showed that pathology of alcoholic encephalopathy was associated with cerebral vascular damage. TMP (tetramethyl- pyrazine) is widely used in the treatment of cerebrovascular diseases, however, it has not been reported whether TMP can relieve alcohol-induced cerebral vascular damages. The study was performed to investigate the learning and memory, cerebrovascular pathological changes and the expressions of vascular endothelial growth factor (VEGF) and serum levelsofendothelin-1 (ET-1) in the rat model of chronic alcoholic encephalopathy, and explore the effects of TMP intervention on alcoholic encephalopathy. In the present study, the rat model of chronic alcoholic encephalopathy was established by the gavage administration of alcohol; the learning and memory ability was tested by Morris water maze; the expression of VEGF was measured by RT-PCR and Western blot; and the serum levels of ET-1 was measured by radioimmunoassay. We found that alcohol intoxication impaired learning and memory, induced VEGF overexpression and increased ET 1 concentrations. TMP intervention improved learning abilities, increased the VEGF expression and reduced ET-1 level. These results indicate that TMP exhibits therapeutic effects on chronic alcoholic encephalopathy.
Alcohol-Induced Disorders, Nervous System ; complications ; drug therapy ; physiopathology ; Animals ; Cerebrovascular Circulation ; drug effects ; Disease Models, Animal ; Endothelin-1 ; blood ; Learning ; drug effects ; Male ; Memory ; drug effects ; Pyrazines ; pharmacology ; therapeutic use ; Random Allocation ; Rats ; Rats, Wistar ; Vascular Endothelial Growth Factor A ; analysis ; Vasodilator Agents ; pharmacology ; therapeutic use