OBJECTIVES: This study aimed to determine the general predictive factors of change in drinking behavior and to provide materials for preventing drinking problems during early adulthood through examining genetic and psychosocial factors affecting the change of drinking behavior in college students. METHODS: The subjects were 101 male college students, a part of 534 students who had completed the previous study in 2000. In the present study as a 6-years follow up, we reassessed the drinking pattern and psychosocial variables and compared the results with previous data of the same subjects. To identify factors affecting the current drinking pattern, we used stepwise multiple regression and logistic regression analysis. RESULTS: D allele (ALDH2) was found to reduce the degree of drinking and suppress problematic drinking, and C allele (TPH) had a suppression effect on problematic drinking. Drinking motive had a direct effect on the degree of drinking and problematic drinking. Negative cognitive expectancy had a direct effect on problematic drinking. CONCLUSION: Authors found some factors affecting the change of alcohol drinking behavior in college students and confirmed that there were hierarchies of significance among these factors. These may be applicable as variables for predicting drinking behavior in early adulthood.
Alcohol Drinking ; Alleles ; Drinking Behavior* ; Drinking* ; Follow-Up Studies ; Humans ; Logistic Models ; Male* ; Psychology*

PURPOSE: This study aimed at exploring relationships among Internet addiction, smoking, and drinking and examining the effect factors on Internet addiction, smoking and drinking. METHODS: By using stratified sampling, 1,529 participants representing high school students in the Kangwon province were selected. Data was analyzed by SPSS 12.0. using chi-square, Pearson correlation coefficient and multiple regression. RESULTS: One-fifth of the total participants were at the mild or moderate stage of Internet addiction. Regarding smoking, 22.7% of male subjects and 4.5% of female subjects were current smokers. Regarding drinking, the percentages of subjects who drank alcohol once or twice per month were 53.5% of male students and 40.7% of female students. Internet addiction positively correlated with depression, novelty seeking, harm avoidance and reward dependence, Internet addiction negatively correlated with persistence, self-directness, cooperativeness, and self-transcendence. Significant factors affecting Internet addiction were depression, gender, novelty seeking, and self-transcendence. Important factors influencing smoking were drinking, gender, school type, satisfaction with school, novelty seeking, and reward dependence. Significant factors affecting drinking were smoking, novelty seeking, school type and ages. CONCLUSION: This study shows the necessity of developing and implementing effective intervention programs in order to prevent adolescents from experiencing Internet addiction and health risk behaviors.
Adolescent ; Adolescent Behavior/*psychology ; Alcohol Drinking/*psychology ; Behavior, Addictive/*psychology ; Depression/psychology ; Female ; Humans ; *Internet ; Male ; Multivariate Analysis ; Smoking/*psychology ; Students/psychology

BACKGROUND: Biochemical markers can provide objective evidence of heavy alcohol drinking. In this study, we investigated the diagnostic usefulness of carbohydrate-deficient transferrin (CDT), a relatively new marker of alcohol consumption. METHODS: We consecutively enrolled 81 participants aged between 28 and 69 years, consisting of 44 alcohol-dependent patients and 37 age-matched controls. Relative values (%) of CDT were determined in their sera with turbidimetric immunoassay (Bio-Rad %CDT assay, Axis-Shield ASA, Oslo, Norway), and were compared with two conventional markers of alcohol consumption, gammaglutamyl transferase (GGT) and mean corpuscular volume (MCV). RESULTS: The distribution patterns of %CDT among alcohol-dependent patients and controls were significantly different from each other (P=0.0000). Of the 44 alcohol-dependent patients, positive results of %CDT (> or =2.6%), GGT (>50 IU/L), and MCV (>98 fL) were observed in 43 (97.7%), 35 (79.5%), and 24 (54.5%) patients, respectively. The areas under the receiver operating characteristic (ROC) curves (95% confidence interval) for %CDT, GGT, and MCV were 0.995 (0.946-1.000), 0.894 (0.805-0.951), and 0.768 (0.661-0.855), respectively. Discrimination between alcohol-dependent patients and controls, as measured by the areas under the ROC curves, was significantly better for %CDT than for GGT and MCV (P=0.000 and P=0.006, respectively). CONCLUSIONS: CDT seems to be the most reliable of the three markers tested for chronic alcohol consumption, and it may provide a useful information to for the objective detection of alcohol-dependent patients.
Alcohol Drinking ; Alcoholism* ; Biomarkers ; Discrimination (Psychology) ; Erythrocyte Indices ; gamma-Glutamyltransferase ; Humans ; Immunoassay ; ROC Curve ; Transferases ; Transferrin*

OBJECTIVE: To establish a model of long-term free drinking mouse by feeding mice with alcohol to simulate the state of human voluntary long-term drinking, and on this basis, to further discuss the evaluation criteria of long-term free drinking mice model in sports, anxiety and cognitive behavior. METHODS: Forty six-week-old SPF C57BL/6 male mouse were randomly divided into two groups: Long-term free drinking group (n=20) and normal control group (n=20). The two groups were given solid feed normally. The long-term free drinking group was free to take 10% alcohol and water every day, while the normal drinking group only took water every day. The mice were fed for 7 months, and were evaluated by a series of behavioral methods, including Rota-rod test, balance beam test, open filed test, the elevated plus maze, two-box social behavior, new object recognition, Y maze and water maze. RESULTS: With the increase of drinking days, the mice showed significant alcohol addiction in the alcohol preference test. With the increase of alcohol intake, the mice in the long-term free choice drinking group had slightly shiny fur and reduced diet. Compared with the control group, the weight gain began to slow down from the third month, and the weight decreased significantly by the sixth and seventh months (P=0.006, P < 0.001). The mice showed reduced balance locomotion ability (P=0.003, P=0.001) in the rotary bar and balance beam test. In the open field and elevated cross test, the mice had obvious anxiety-like behavior (P < 0.001). The mice showed decreased social ability in the two boxes of social behavior (P < 0.016). In the experiment of new object recognition and Y maze, the exploration of new object decreased (P=0.018, P=0.040). In the water maze, cognitive functions, such as learning and spatial memory were reduced (P < 0.001). CONCLUSION The successful establishment of the long-term free drinking mouse model is more convenient for us to carry out further research on the neural mechanism of alcohol addiction, and lays an experimental foundation for exploring the neural mechanism of alcohol addiction and related new targets.
Mice ; Male ; Humans ; Animals ; Alcoholism ; Mice, Inbred C57BL ; Alcohol Drinking/psychology* ; Anxiety ; Disease Models, Animal ; Ethanol

PURPOSE: This study examined the association between early initiation of problem behaviors (alcohol drinking, cigarette smoking, and sexual intercourse) and suicidal behaviors (suicidal ideation and suicide attempts), and explored the effect of concurrent participation in these problem behaviors on suicidal behaviors among Korean adolescent males and females. MATERIALS AND METHODS: Data were obtained from the 2006 Korean Youth Risk Behavior Survey, a nationally representative sample of middle and high school students (32,417 males and 31,467 females) in grades seven through twelve. Bivariate and multivariate logistic analyses were conducted. Several important covariates, such as age, family living structure, household economic status, academic performance, current alcohol drinking, current cigarette smoking, current butane gas or glue sniffing, perceived body weight, unhealthy weight control behaviors, subjective sleep evaluation, and depressed mood were included in the analyses. RESULTS: Both male and female preteen initiators of each problem behavior were at greater risk for suicidal behaviors than non-initiators, even after controlling for covariates. More numerous concurrent problematic behaviors were correlated with greater likelihood of seriously considering or attempting suicide among both males and females. This pattern was more clearly observed in preteen than in teen initiators although the former and latter were engaged in the same frequency of problem behavior. CONCLUSION: Early initiation of alcohol drinking, cigarette smoking, and sexual intercourse, particularly among preteens, represented an important predictor of later suicidal ideation and suicide attempts in both genders. Thus, early preventive intervention programs should be developed and may reduce the potential risks for subsequent suicidal behaviors.
Adolescent ; Adolescent Behavior/psychology ; Adult ; Alcohol Drinking/*psychology ; Female ; Humans ; Korea ; Male ; Sexual Behavior/*psychology ; Smoking/*psychology ; Suicide, Attempted/*psychology ; Time Factors ; Young Adult

PURPOSE: This study was to explore the prevalence of alcohol experiences and to identify the expectancy on the effects of alcohol and alcohol knowledge in early adolescents. METHOD: The cross-sectional survey of 1854 students from seven middle schools in one district of Seoul was conducted by convenience sampling. Alcohol experience and early onset of alcohol use were measured by the Youth Risk Behavior Survey. Alcohol expectancy was measured by an Alcohol Effects Questionnaire. RESULT: Over sixty five percent of adolescents reported that they had previous drinking experiences. The participants with no alcohol drinking experience had a lower level of alcohol knowledge than those with experience(t=2.73, p=.007). In expectancy on effects of alcohol, girls had a more positive alcohol expectation than boys(t=-2.54, p=.011). Alcohol knowledge negatively correlated with alcohol expectancy(r=-.40 p=.000). In regression of alcohol expectancy, gender and alcohol knowledge were significant predictors explaining 17%. CONCLUSION: The results support that alcohol expectancy is an important link with early drinking experiences and alcohol knowledge, focusing on the importance of gender differences. Therefore, an alcohol prevention program in early adolescence is needed and should be focused on multidimensionality of the alcohol expectancy with developmental and psychosocial factors for early adolescents.
Adolescent ; Adolescent Behavior/*psychology ; Alcohol Drinking/*epidemiology/psychology ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Questionnaires ; Regression Analysis ; Risk-Taking

OBJECTIVETo explore the relationships between alcohol expectancy,cultural orientation, self-efficacy and drinking behavior to provide theoretical support for the development of education programs aimed at preventing alcohol abuse among adolescents.

METHODSAn anonymous quantitative survey of 2756 tenth and eleventh grade students in six senior high schools in Zhengzhou and Xinyang city of Henan province was conducted in November 2005 and data was analyzed by SPSS 13.0 software.

RESULTSThe overall rate of drinking alcohol among participants was 56.5%. The median score of cultural orientation was 3.25 (3.09, 3.42); of alcohol expectancy was 3.02 (2.81, 3.23); and 79.64 (60.36, 93.21) of alcohol self-efficacy. Direct or indirect relationships were found between Chinese traditional cultural orientation, western cultural orientation, alcohol positive expectancy, alcohol negative expectancy, alcohol self-efficacy and alcohol drinking behavior. Lower monthly drinking habit was directly associated with higher self-efficacy and higher negative expectancies,lower positive expectancies and lower western cultural orientation (coefficients = -0.346, -0.282, 0.234 and 0.162 respectively), but not with Chinese cultural orientation variables.

CONCLUSIONThe current situation of alcohol drinking among the participants was critical. Drinking behavior seemed most affected by drinking beliefs and cultural orientation, suggesting that the development of education programs should focus on students' beliefs.

Adolescent ; Alcohol Drinking ; psychology ; Alcoholism ; prevention & control ; China ; Culture ; Female ; Health Education ; Humans ; Male ; Self Efficacy ; Students ; psychology

OBJECTIVETo evaluate the health-related quality of life (HRQOL) in chronic hepatitis C (CHC) female patients, and to identify factors associated with impairment in HRQOL.

METHODSWe enrolled 41 women cases with hepatitis C for 10 to 15 years and 51 health women in Guan area of Hebei province, China. HRQOL was assessed by the SF-36 by an interview.

RESULTSCHC female patients had significantly lower SF-36 scors in all subscales when compared to those of the non-HCV infected female population.

CONCLUSIONCHC female patients have a reduced HRQOL. CHC alone is associated with significant impairment in HRQOL.

Adult ; Aged ; Alcohol Drinking ; psychology ; Female ; Hepatitis C, Chronic ; psychology ; Humans ; Middle Aged ; Quality of Life ; RNA, Viral ; analysis

PURPOSE: This study aimed to examine the most prominent health-related behaviors impacting the academic performance of Korean adolescents. METHODS: The 2012 Korea Youth Risk Behavior Web-Based Survey data were analyzed using an ordinal regression analysis after adjusting for general and other health behaviors. RESULTS: Before adjustment, all health behaviors were significantly associated with academic performance. After adjustment for other health behaviors and confounding factors, only smoking [odds ratio (OR) = 2.07, 95% confidence interval (CI) (1.98, 2.16), p < .001], alcohol consumption [OR = 1.22, 95% CI (1.18, 1.27), p < .001], and physical activity [OR = 1.09, 95% CI (1.06, 1.13), p < .001] were associated with lower academic performance, and engaging in a regular diet [OR = 0.65, 95% CI (0.65, 0.62), p < .001] was associated with higher academic performance. CONCLUSIONS: Regular diet, reducing smoking and alcohol drinking, and physical activity should be the target when designing health interventions for improving academic performance in Korean adolescents.
*Achievement ; Adolescent ; Alcohol Drinking/psychology ; Diet/psychology ; Educational Status ; Exercise/psychology ; Female ; *Health Behavior ; Health Status ; Humans ; Male ; Republic of Korea ; Smoking/psychology ; Social Class

In recent years, the traffic accidents increased gradually, especially those caused by the drivers daily emotional abnormality and in which the drivers were liable. This article reviewed the traffic accidents caused by divorced driver's emotional abnormality, illustrated the features of those accidents from the gender, age, occupation and mileage of drivers. It was considered that the major cause of those accidents was excessive drinking due to drivers' emotional stress. Suggestions about preventing the traffic accidents caused by emotional abnormality were put forward so as to make the corresponding rules and finally decrease the emotional abnormality traffic accidents.
Accidents, Traffic/prevention & control* ; Alcohol Drinking/psychology* ; Automobile Driving/psychology* ; Divorce/psychology* ; Female ; Forensic Medicine ; Humans ; Male ; Middle Aged ; Stress, Psychological/psychology*