1.Detection of Malignant Primary Hepatic Neoplasms with Gadobenate Dimeglumine (Gd-BOPTA) Enhanced T1-Weighted Hepatocyte Phase MR Imaging: Results of Off-site Blinded Review in a Phase-II Multicenter Trial.
Constantino S PENA ; Sanjay SAINI ; Richard L BARON ; Bernd A HAMM ; Giovanni MORANA ; Roberto CAUDANA ; Andrea GIOVAGNONI ; Andrea VILLA ; Alessandro CARRIERO ; Didier MATHIEU ; Michael W BOURNE ; Miles A KIRCHIN ; Gianpaolo PIROVANO ; Alberto SPINAZZI
Korean Journal of Radiology 2001;2(4):210-215
OBJECTIVE: To investigate the efficacy of gadobenate dimeglumine (Gd-BOPTA) enhanced MR imaging for the detection of liver lesions in patients with primary malignant hepatic neoplasms. MATERIALS AND METHODS: Thirty-one patients with histologically proven primary malignancy of the liver were evaluated before and after administration of Gd-BOPTA at dose 0.05 or 0.10 mmol/kg. T1-weighted spin echo (T1W-SE) and gradient echo (T1W-GRE) images were evaluated for lesion number, location, size and confidence by three off-site independent reviewers and the findings were compared to reference standard imaging (intraoperative ultrasound, computed tomography during arterial portography or lipiodol computed tomography). Results were analyzed for significance using a two-sided McNemar's test. RESULTS: More lesions were identified on Gd-BOPTA enhanced images than on unenhanced images and there was no significant difference in lesion detection between either concentration. The largest benefit was in detection of lesions under 1 cm in size (7 to 21, 9 to 15, 16 to 18 for reviewers A, B, C respectively). In 68% of the patients with more than one lesion, Gd-BOPTA increased the number of lesions detected. CONCLUSION: Liver MR imaging after Gd-BOPTA increases the detection of liver lesions in patients with primary malignant hepatic neoplasm.
Adenoma, Liver Cell/*diagnosis
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Adult
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Aged
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*Contrast Media
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Female
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Human
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Image Enhancement
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Liver Neoplasms/*diagnosis
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Magnetic Resonance Imaging/*methods
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Male
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Meglumine/*analogs & derivatives/*diagnostic use
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Middle Age
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Organometallic Compounds/*diagnostic use