100 white mice were divided in two groups, 50 mice for each one. The experimental group was exposed to Bassa 50EC with dose of 30 mg/kg body weight orally during 60 days. The other one was taken distilled water with a similar dose and time. The results showed that SGOT and SGPT enzyme activities in blood of experimental mice increased after exposing to Bassa.
Aspartate Aminotransferases ; Alanine Transaminase ; blood

Alanine Transaminase ; blood ; Hepatitis B, Chronic ; blood ; pathology ; Humans

BACKGROUND/AIMS: Nonalcoholic fatty liver disease (NAFLD) comprises a large part of chronic liver diseases. Recently it was reported that adipokines are closely associated with the common risk factors for NAFLD, such as obesity, diabetes, dyslipidemia, and insulin resistance. We aimed to evaluate the changes in serum adiponectin, resistin and leptin concentrations related to alanine aminotransferase (ALT) elevations in Korean men with NAFLD. METHODS: We studies 38 men who were diagnosed with fatty liver by abdominal ultrasonography. None had a history of excessive alcohol consumption, autoimmune hepatitis, inherited or metabolic liver disease or viral hepatitis. The subjects were divided into two groups. One group had normal levels of ALT (n=28) and the other had increased ALT (n=10). We compared anthropometrical parameters, biochemical items and serum adipokine levels between these two groups. RESULTS: Serum adiponectin levels were lower in the increased ALT group than in the normal ALT group (3.89 +/- 1.77 vs 7.01 +/- 2.54 microgram/dL, P=0.001). But there were no significant differences in serum leptin and resistin levels between two groups (4.02 +/- 2.04 vs 3.26 +/- 1.41 ng/mL, p=0.245, 80.14 +/- 14.8 vs 80.5 +/- 11.34 ng/mL, P=0.937, respectively). Multiple linear regression analyses demonstrated that the serum adiponectin level is inversely correlated with serum ALT level and that the serum aspartate aminotransferase (AST) level is positively correlated with the serum ALT level. CONCLUSIONS: Our study shows that hypoadiponectinemia is associated with an ALT elevation in patients with NAFLD. Adiponectin may play an indirect role in the development of NAFLD.
Resistin/blood ; Middle Aged ; Male ; Leptin/blood ; Humans ; Fatty Liver/*blood ; Alanine Transaminase/*blood ; Aged ; Adiponectin/blood

Alanine Transaminase ; blood ; Aspartate Aminotransferases ; blood ; Female ; Humans ; Liver ; pathology ; Liver Diseases, Alcoholic ; blood ; diagnosis ; Male ; gamma-Glutamyltransferase ; blood

In order to ascertain the status of health damage among Korean farmers who spray pesticides regularly in summer, blood and urine samples were collected for 88 volunteers during July to Septembei in 1990. Serum cholinesterase activity, parent compounds of pesticides in blood and urine, SGOT, SGPT, blood pressure, pulse rate were measured. The results were as follows ; 1. Mean cholinesterase activity after spraying pesticides was significantly lower than that before splaying. While proportion of abnormal cholinesterase activity (<1900U/L) group was 2.3% before spraying pesticides, tHe proportion of the group after spraying was 22.8% 2. Cholinesterase activity were decreased over 50% in 14.7% of the suhjects who can be classified into poisoning group 3. While pulse rate and blood pressure were slightly increased in poisoning group, those were significantly decreased in non-poisoning group. 4. Consecutive splaying of pesticide caused further reduction of cholinesterase activity, 5. Five parent compounds of pesticides frequently used during summer farming were analyzed using 106 blood samples. IBP in one sample and Isoprothiolane in four samples were detected. No parent compounds were detected in urine samples.
Alanine Transaminase ; Aspartate Aminotransferases ; Blood Pressure ; Cholinesterases* ; Heart Rate ; Humans ; Parents ; Pesticides ; Poisoning ; Volunteers

The antihypertensive effects of tripamide was studied in 19 cases of essential hypertension. After 4 weeks treatment with daily dosage of Tripamide (Normonal(R)) 15mg, the dosage was adjusted to 30mg in 10 cases. Before and after treatment laboratory tests were performed in 11 cases. The obtained results were as follows: 1) After 4 weeks treatment with daily dosage of Tripamide 15mg, mean systolic and diastolic blood pressure was decreased by 25 mmHg (12.7%) and 9.7 mmHg (8.5%) respectively(p<0.01), and in 58% of the cases, good or fair control of blood pressure was resulted. 2) After final treatment, mean systolic and diastolic blood pressure was decreased by 29.7 mmHg(15.1%) and 15.0 mmHg(120.5%) respectively(p<0.005) and in 79% of the cases, good or fair control of blood pressure was resulted. 3) There was no significant changes in the values of sodium, potassium, BUN, creatinine, uric acid, cholesterol, SGOT, SGPT and calcium after treatment. 4) There was no significant side effect except one case of mild fatigue and tingling sense of extrmities which were subsided spontaneousely.
Alanine Transaminase ; Aspartate Aminotransferases ; Blood Pressure ; Calcium ; Cholesterol ; Creatinine ; Fatigue ; Hypertension ; Potassium ; Sodium ; Uric Acid

The effect of three anesthetics on the plasma lipid and enzyme were compared in patients with hypertension who required surgery. Thirty patients were divided into three groups of ten; Group l : normal blood pressure with normal plasma cholesterol, Group ll : high blood pressure with normal plasma cholesterol, Group lll : high blood pressure with high plasma cholesterol. The patients in each group randomly received one of these three anesthetics, halothane, enflurane and Innovar. Measurement of SGOT, SGPT, serum cholesterol, r-GT and triglyceride were made on the preoperative day, immediate postoperative period, 24 th and 48 th postoperative hour with the following conclusions. 1) Effects of the three anesthetics on the plasma lipid and enzyme in the three groups were similar in the postoperative period (P>0.05) . 2) The trend of SGOT, SGPT and trig1yceride showed cubic equational changes(P<0.001).
Alanine Transaminase ; Anesthetics* ; Aspartate Aminotransferases ; Blood Pressure ; Cholesterol ; Enflurane ; Halothane ; Humans ; Hypertension ; Plasma* ; Postoperative Period ; Triglycerides

Subjective symptoms, counts of blood cells and liver function test were conducted on 198 male workers who were exposed to toluene in Kyungin area from September to November, 1986. According to level of urinary hippuric acid concentration, the total sample was classified into the high exposure group (concentration > or = 3g/l) and the low exposure group(concentration < 3g/l). The following findings were obtained by comparing the two group: 1) Contrary to the previous findings, the urinary hippuric acid concentration of toluene exposed workers showed bimodal distribution. It meant that the toluene exposed workers were mixed with the non-exposed or minimal exposed workers. 2) The high exposure group showed a lower level of leucocccytes counts (6,630+/-1,860/microliter) than the low exposure group (6,340+/-1,960/microliter). 3) The high exposure group showed a higher level of SGOT, SGPT and r-GTP than the low exposure group(P<0.05). 4) The high exposure group complained much more subjective symptoms (e.g. skin rash, loss of appetite, palpitation) than the low exposure group.
Alanine Transaminase ; Appetite ; Aspartate Aminotransferases ; Blood Cells ; Exanthema ; Humans ; Liver Function Tests ; Male ; Toluene*

BACKGROUND: In Korea, since 1990, in an effort to reduce the transmission of non-A, non-B hepatitis, all blood donations with alanine aminotransferase (ALT) levels above 65 IU/L are discarded. In 2012, 64.8% of the disposed blood units at the Korean Red Cross blood centers were due to high ALT levels. Pre-donation ALT testing might prevent unnecessary blood donation and save related expenses. We evaluated performance of point-of-care test (POCT) devices for pre-donation ALT screening. METHODS: ALT levels by four ALT POCT devices (Mission C100, Acon; Reflotron Plus, Roche; Labgeo PT10, Samsung; and FDC NX500, Fujifilm) were compared with venous blood results using laboratory chemistry analyzers (AU series, Beckman Coulter Inc.). Intraclass correlation coefficients (ICCs), sensitivity (ability to detect ALT > or =65 IU/L), and specificity (ability to detect <65 IU/L) for each method were calculated. RESULTS: Compared with the laboratory analyzers, the ICCs of ALT measurements by Mission C-100, Reflotron Plus, Labgeo PT10, and FDC NX500 were 0.96 (95% confidence interval (CI): 0.95~0.97), 0.99 (95% CI: 0.99~0.99), 0.98 (95% CI: 0.98~0.98), and 0.94 (95% CI: 0.91~0.96), respectively. The sensitivity was 80.95% for Mission C-100, 83.33% for Reflotron Plus, 78.57% for Labgeo PT10, and 97.62% for FDC NX500. The specificity was 99.13% for Mission C-100, 100.00% for Reflotron Plus, 99.78% for Labgeo PT10, and 98.26% for FDC NX500. CONCLUSION: The ALT POCT devices showed almost perfect agreement with the laboratory analyzers and could be useful for pre-donation ALT screening. However, before implementing ALT POCT devices, cost-effectiveness analyses should be performed.
Alanine Transaminase* ; Blood Donors ; Chemistry ; Hepatitis ; Humans ; Korea ; Mass Screening ; Missions and Missionaries ; Red Cross ; Sensitivity and Specificity

Induced hypotension is a well established adjunct to anesthesia which provides improved operating conditions for a wide variety of surgical procedures without significantly increasing the risk to the patient. Since introduction of hypotensive anesthesia in 1964 by Gardner, there has been a wide choice of methods for inducing hypotension during anesthesia, most of which are based on the concept of arteriolar dilatation. Hypotensive anesthesia was attempted on ten patients for total hip replacements which were done at Gospel Hospital, from Feb. to Oct. in 1979. The patients selected did not have a liver problem, and this was determined by SGOT and SGPT, and without a limit of age or sex. The hypotension was induced with 2~3% halothane, 50% N2O and 50%, O2and the blood pressure averaged for systolic pressure 71. 22 mmHg and for diastolic pressure 50. 09 mmHg, The average duration of the induced hypotension was 57. 0 minutes and the blood loss during operation was 300 ml on average. During the hypotensive anesthesia, the urine output decreased by 27. 0% and during the recovery period from hypotension urine output increased by 20%. On our experience, we can conclude that hypotensive anesthesia provides good operative conditions and can be performed without damage to vital organs and can reduce blood loss during operation.
Alanine Transaminase ; Anesthesia* ; Arthroplasty, Replacement, Hip* ; Aspartate Aminotransferases ; Blood Pressure ; Dilatation ; Halothane ; Humans ; Hypotension ; Liver