Effects of hot bathing on blood coagulation and fibrinolysis were studied in 35 patients with various diseases by measuring pulse rate and blood pressure and performing peripheral blood and hemostatic examinations before and after a 10-minute hot bath at 40 to 42°C.
Pluse rate increased significantly during the hot bath (p<0.001) However, no changes were observed in the results of blood pressure and perpheral blood examinations.
APTT, PT, fibrinogen, factor II, V, VII, VIII, IX, X, XI, XII, von Willebrand factor, prekallikrein, and antithrombin III were measured during coagulation examinations, but no significant changes were observed between those factors before and after hot bathing.
Although no significant changes were shown in plasminogen and antiplasmin during hot bathing, euglobulin lysis time (ELT) was significantly (p<0.001) reduced during the hot bath. It remains to be determined whether the reduction in ELT is due to the release of a tissue-type plasminogen activator from the vascular endothelial cells.
The reduction rate of ELT was studied in patients with each type of disease. The reduction rate of ELT in the patients with hypertension (HT) was larger than that in the patients without HT, and that in the patients with cerebral vascular accident (CVA) was also larger than that in the patients without CVA. However, the reduction rate of ELT in the patients with diabetes mellitus (DM) was smaller than that in the patients without DM. The patients with CVA, HT or DM are considered to have vascular damages. In the effect of hot bathing on fibrinolysis, however, there is a difference in reduction rate of ELT between patients with HT or CVA and those with DM.
This study indicates that pulse rate is increased during hot bathing and fibrinolysis is accelerated.

OBJECTIVES: There is increasing evidence that systemic inflammatory response (SIR) markers are prognostic factors for various types of cancers. This is the first study to evaluate the usefulness of SIR markers for the prognosis of early-stage ovarian clear-cell carcinoma (OCCC). METHODS: We retrospectively investigated 83 patients diagnosed with stage I–II OCCC who underwent surgery between 2005 and 2017. Initially, receiver operating characteristic curve analysis for overall survival (OS) was used to determine optimal cut-off values for neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Patients were stratified into 2 groups by the cut-off values (NLR=3.26, PLR=160). Univariate and multivariate analyses were performed to elucidate the significance of SIR markers as prognostic factors. RESULTS: In the median follow-up period of 64.1 months, 16 patients experienced recurrence, and nine patients died. The Kaplan-Meier curve showed that OS of the NLR-low group was significantly longer than the NLR-high group (p=0.021). There was no significant difference in progression-free survival between the 2 groups (p=0.668), but the post-recurrence survival of the NLR-low group was significantly longer than the NLR-high group (p=0.019). Furthermore, multivariate analysis showed that increase in NLR is a significant independent prognostic factor for poor prognosis (hazard ratio=7.437, p=0.017). There was no significant difference between PLR-low and PLR-high group. CONCLUSION: Results suggest that NLR can be a significant independent prognostic factor for early-stage OCCC.
Adenocarcinoma, Clear Cell ; Biomarkers ; Disease-Free Survival ; Follow-Up Studies ; Humans ; Multivariate Analysis ; Prognosis ; Recurrence ; Retrospective Studies ; ROC Curve