2.CITYWARD MIGGATION AND HOME-COMING OF RURAL PEOPLE IN REMOTE MOUNTS IN VILLAGES AND ITS DEMOGRAPHICAL PROBLEMS
Akio Uchida ; Fuki Uchida ; Isamu Kaneko ; Akira Tanaka ; Keiichi Ogura
Journal of the Japanese Association of Rural Medicine 1966;13(2):126-136
The outstanding feature of the drift of population observed in our country of late is understood in terms of the population exodus from rural areas into urban or industrial areas, which brings about. a conspicuous decrease in rural population especially in that of the younger working age bracket. with a view to clarifying an aspect of such wide-ranging migration of population, a study was made in the three remote mountain villages in the Chilbu District, where people are living on an extremely low economic level Investigation conducted for eacch respective economic level revealed an even. abnormally advanced decrease in the population of such younger generation, far advanced than in average rural areas. Thus the unfavorable topogra-phical conditions, lack of cultivating lands, low income, etc.were considered to be responsible for the acceleration of such population exodus. Attention was also drawn to the fact that not only the surplus labor power but even many of the eldest sons. who are the successors to their fathers' occupations are turning to urban areas for employ-ment, threatening the possibility of the replenishment of agricultural labor power and the development of agricultural economics, as well as the future reproduction of population in rural areas.
3.Review of Surgical Cases of Gastric Cancer
Nobuyuki KOBAYASHI ; Fusakuni KURODA ; Takashi DOI ; Makoto KINOUCHI ; Yasuhiro WATANABE ; Akira ODA ; Naoyuki KANEKO
Journal of the Japanese Association of Rural Medicine 2003;51(6):939-943
This paper describes a clinical review of cases of gastric cancer treated surgically at the Department of Surgery of the Shirakawa Kosei General Hospital, the core medical institution in the southern part of Fukushima Prefecture.
During the period of 20 years from January 1981 through December 2000, a total of 1, 132 cases were operated on for gastric carcinoma. Surgical resection cases totaled 1, 023 (resection ratio: 90.4%); curative resection cases, 894 (curative resection ratio: 79.0%); 5-year survival rate for resection cases, 68.3%; and 5-year survival rate for curative resection cases, 75.6%. When the cases were divided into those treated during the first half of the 20 years nad those treated during the latter half of the 20 years, the number or resection cases was smaller during the latter than during the first half but the resection ratio was larger. The early stomach cancer cases in terms of the degree of progress, histological classification, depth and metastasis to lymph nodes have been increasing and the 5-year survival rate has been on the rise.
4.Effects of tu-chung extract administrating on serum testosterone in hindlimb-suspended rats .
GANG-JIAN QU ; HIROSHI KANEKO ; NAOYUKI EBINE ; KAYOKO KITA ; SEIJI TOMITA ; TOSHIO MIKAMI ; YOUSUKE TASAKI ; AKIRA ITO
Japanese Journal of Physical Fitness and Sports Medicine 1999;48(4):501-507
The purpose of this research was to study the effects of Tu-Chung extract (Eucommia ulmoides OLIV.) administration on serum testosterone and the possible mechanisms in hindlimb- suspended rats. 25 five-week old male Wistar rats were used. All rats were randomly divided into two groups : those treated with Tu-Chung extract (Tu-Chung G, n=suspended for 37 days in hindlimb. 1 mg/ml Tu-Chung extract was administered orally once daily at a dose of 1 ml/100 g body weight. Distilled water was administered in a similar way to the control group. The following results were observed :
1. Serum testosterone concentration in Tu-Chung G was significantly higher than in Cont. G (P<0.001) .
2. There was no significant difference between Tu-Chung G and Cont. G in serum LB concentrations.
3. The Testicular cAMP level in Tu-Chung G was significantly higher than that in Cont. G (P<0.01) .
4. 24-h urinary excretion of 17-ketosteroid in Tu-Chung G was significantly higher than that in Cont. G (P<0.001) .
5. There were no significant differences between the two groups in the weights per body weight of the kidneys, adrenal grand and testes. These results suggest that the adininstration of Tu-Chung extract inducing high serum testosterone concentrations in hindlimb-suspended rats might be due to enhanced testicular and adrenal functions, not pituitary.
5.CTLA-4 polymorphisms and anti-malarial antibodies in a hyper-endemic population of Papua New Guinea
hikota osawa ; marita troye-blomberg ; kenji hirayama ; mihoko kikuchi ; francis hombhanje ; takeo tanihata ; rachanee udomsangpetch ; anders björkman ; takatoshi kobayakawa ; akira kaneko
Tropical Medicine and Health 2008;36(2):93-100
In malaria endemic areas, people naturally acquire an age-related immunity to malaria. Part of this immunity involves anti-malarial specific antibodies. Acquisition of these malaria-specific antibodies depends not only on exposure to malaria parasites but also on the human genetic predisposition. CTLA-4 is a costimulatory molecule that delivers an inhibitory signal to suppress T-cell as well as B-cell responses. We investigated associations between malaria-specific antibody levels and CTLA-4 polymorphisms in 189 subjects living in a hyper-endemic area of Papua New Guinea (PNG), where both P. falciparum and P. vivax are prevalent. We determined P. falciparum⁄ P. vivax specific IgG⁄IgE levels (Pf-IgG, Pv-IgG, Pf-IgE, Pv-IgE) and polymorphisms in the CTLA-4 gene at position -1661 promoter region (A⁄G), the +49 exon 1 non-synonymous mutation (A⁄G), and the +6230 3‘-UTR (A⁄G). All quantified antibody levels were significantly higher in subjects > 5 years (n = 150) than in subjects ≤ 5 years of age (n = 39). In children ≤ 5 years old, significant associations were detected between CTLA-4 +49 (GG⁄AG vs. AA) and Pv-IgG (median 18.7 vs. 13.7 Μg⁄ml, P = 0.017) and Pv-IgE (266.6 vs. 146.5 pg⁄ml, P = 0.046). No significant difference was observed in subjects > 5 years old. These results suggest that the CTLA-4+49 polymorphism influenced Pv-IgG and Pv-IgE levels among children less than five years old in the studied population, which may regulate the age- and species-specific clinical outcomes of malaria infection.
6.Improvement of Student Presentations Via the Introduction of Presentation Evaluation sheets
Akira NAKASHIMA ; Kazunao KONDO ; Eiichi MIYACHI ; Narushi IIZUKA ; Kazuhisa IKEMOTO ; Satoru ISHIHARA ; Mahito OHKUMA ; Yoko KANEKO ; Fusao KAWAI ; Yu KODANI ; Yui SUGANUMA ; Hiroshi NAGASAKI ; Nobuhiro HARADA ; Tomoaki YOSHIDA ; Hidehito INAGAKI ; Kunihiro TSUCHIDA ; Hisateru YAMAGUCHI
Medical Education 2017;48(5):323-325
7.Patient with Heterotopic Ossification Post-SARS‑CoV‑2 Infection Regained Ability to Walk Independently Indoors after Rehabilitation and Drug Therapy:A Case Report
Yuki YOKOKAWA ; Satoshi OKUDA ; Yuta HAYASHI ; Mariko KANEKO ; Ikuko AIBA ; Akira INUKAI
The Japanese Journal of Rehabilitation Medicine 2024;():23031-
A 31-year-old woman infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) at 33-weeks pregnant was subject to cesarean delivery due to a worsening respiratory condition. On the fourth day of illness, the patient was placed on a ventilator, with extracorporeal membrane oxygenation (ECMO) treatment initiated on the ninth day. Passive range of motion (ROM) training started on the day 33 of illness. She was weaned off ECMO on day 55 of illness and taken off of the ventilator on day 8. The tracheostomy tube was replaced with a speech cannula on day 87 of illness, at which time the patient began to complain of pain during passive ROM training. Plain X-ray photography and computed tomography (CT) showed ossification around the bilateral shoulder and hip joints, as well as on medial thighs, accompanied by an alkaline phosphatase (ALP) value of 942 U/L. She was subsequently diagnosed with heterotopic ossification, after which passive ROM training was changed to protective ROM training, in addition to treatment with indomethacin farnesyl and etidronate disodium. The patient was transferred to our hospital on day 122 of illness for the purpose of continuing rehabilitation. On day 155 of illness, ossification decreased on the medial thighs, according to CT. She was able to walk independently indoors and was discharged home on day 181 of illness. This case demonstrates the importance of checking the ALP levels and palpating the periarticular area in patients infected with SARS‑CoV‑2 before initiating passive ROM training, as well as being aware of any pain experienced during training. In the case of any abnormalities, assessing the ossification around the joints of extremities by imaging examination is a priority.
8.Kampo Medicine Maorenshoshakushozuto is Effective for Psoriasis Vulgaris : A Case Report and Literature Review
Akira KANEKO ; Kazushi UNEDA ; Takumi KAYO ; Shuichiro AKIBA ; Masao SUZUKI ; Tadamichi MITSUMA
Kampo Medicine 2024;75(1):53-58
Psoriasis vulgaris is a chronic disease in which demarcated erythema and rashes with silvery-white scales occur at various sites, and it is sometimes intractable. We report that Kampo medicines are effective in the treatment of psoriasis vulgaris. An 83-year-old woman suffered from erythema with pruritus and strong redness on the trunk and upper limbs and she visited the dermatology department. She was diagnosed with psoriasis vulgaris and started treatment with betamethasone ointment. However, her symptoms did not improved, and she requested Kampo medicine treatment. After the administration of maorenshoshakushozuto, erythema gradually improved. Maorenshoshakushozuto is effective for the dermatological diseases with pruritus and strong redness like psoriasis vulgaris.