1.Investigation on the reliability of teaching evaluation by medical students
Akinobu YOSHIMURA ; Toshiro SHIMURA ; Ryoko ASO ; Toshihiro TAKIZAWA ; Shigeo AKIRA ; Hirooki KUNINOBU ; Akira TERAMOTO
Medical Education 2007;38(6):377-381
There are some methods of evaluating teaching: student-, self-, peer- and third person-evaluation etc. Validity, reliability and feasibility are required for assessing the quality of teaching. Therefore, we examined the reliability of teaching evaluation by medical students in Nippon Medical School in comparison with peer evaluation.
1) Twenty-four clinical lectures during the same school year were arbitrarily chosen as objectives. Correlations between student- and peer-evaluations in both generalized ratings and global assessment were analyzed by Pearson's correlation coefficient and Spearman's correlation coefficient by rank.
2) In generalized ratings, a significant correlation between the evaluations was demonstrated (r=0.532, p=0.0056), while a marginal correlation between the evaluations was observed in global assessment (p=0.0492).
3) The results probably provide evidence of the reliability of teaching evaluation by medical students.
4) The criteria for evaluation and the validity of questionnaires should be defined for a more reliable teaching evaluation by medical students.
2.Limited Effect of Rebamipide in Addition to Proton Pump Inhibitor (PPI) in the Treatment of Post-Endoscopic Submucosal Dissection Gastric Ulcers: A Randomized Controlled Trial Comparing PPI Plus Rebamipide Combination Therapy with PPI Monotherapy.
Kazuhiko NAKAMURA ; Eikichi IHARA ; Hirotada AKIHO ; Kazuya AKAHOSHI ; Naohiko HARADA ; Toshiaki OCHIAI ; Norimoto NAKAMURA ; Haruei OGINO ; Tsutomu IWASA ; Akira ASO ; Yoichiro IBOSHI ; Ryoichi TAKAYANAGI
Gut and Liver 2016;10(6):917-924
BACKGROUND/AIMS: The ability of endoscopic submucosal dissection (ESD) to resect large early gastric cancers (EGCs) results in the need to treat large artificial gastric ulcers. This study assessed whether the combination therapy of rebamipide plus a proton pump inhibitor (PPI) offered benefits over PPI monotherapy. METHODS: In this prospective, randomized, multicenter, open-label, and comparative study, patients who had undergone ESD for EGC or gastric adenoma were randomized into groups receiving either rabeprazole monotherapy (10 mg/day, n=64) or a combination of rabeprazole plus rebamipide (300 mg/day, n=66). The Scar stage (S stage) ratio after treatment was compared, and factors independently associated with ulcer healing were identified by using multivariate analyses. RESULTS: The S stage rates at 4 and 8 weeks were similar in the two groups, even in the subgroups of patients with large amounts of tissue resected and regardless of CYP2C19 genotype. Independent factors for ulcer healing were circumferential location of the tumor and resected tissue size; the type of treatment did not affect ulcer healing. CONCLUSIONS: Combination therapy with rebamipide and PPI had limited benefits compared with PPI monotherapy in the treatment of post-ESD gastric ulcer (UMIN Clinical Trials Registry, UMIN000007435).
Adenoma
;
Cicatrix
;
Cytochrome P-450 CYP2C19
;
Endoscopy
;
Genotype
;
Humans
;
Multivariate Analysis
;
Prospective Studies
;
Proton Pump Inhibitors
;
Proton Pumps*
;
Protons*
;
Rabeprazole
;
Stomach Neoplasms
;
Stomach Ulcer*
;
Ulcer
3.Limited Effect of Rebamipide in Addition to Proton Pump Inhibitor (PPI) in the Treatment of Post-Endoscopic Submucosal Dissection Gastric Ulcers: A Randomized Controlled Trial Comparing PPI Plus Rebamipide Combination Therapy with PPI Monotherapy.
Kazuhiko NAKAMURA ; Eikichi IHARA ; Hirotada AKIHO ; Kazuya AKAHOSHI ; Naohiko HARADA ; Toshiaki OCHIAI ; Norimoto NAKAMURA ; Haruei OGINO ; Tsutomu IWASA ; Akira ASO ; Yoichiro IBOSHI ; Ryoichi TAKAYANAGI
Gut and Liver 2016;10(6):917-924
BACKGROUND/AIMS: The ability of endoscopic submucosal dissection (ESD) to resect large early gastric cancers (EGCs) results in the need to treat large artificial gastric ulcers. This study assessed whether the combination therapy of rebamipide plus a proton pump inhibitor (PPI) offered benefits over PPI monotherapy. METHODS: In this prospective, randomized, multicenter, open-label, and comparative study, patients who had undergone ESD for EGC or gastric adenoma were randomized into groups receiving either rabeprazole monotherapy (10 mg/day, n=64) or a combination of rabeprazole plus rebamipide (300 mg/day, n=66). The Scar stage (S stage) ratio after treatment was compared, and factors independently associated with ulcer healing were identified by using multivariate analyses. RESULTS: The S stage rates at 4 and 8 weeks were similar in the two groups, even in the subgroups of patients with large amounts of tissue resected and regardless of CYP2C19 genotype. Independent factors for ulcer healing were circumferential location of the tumor and resected tissue size; the type of treatment did not affect ulcer healing. CONCLUSIONS: Combination therapy with rebamipide and PPI had limited benefits compared with PPI monotherapy in the treatment of post-ESD gastric ulcer (UMIN Clinical Trials Registry, UMIN000007435).
Adenoma
;
Cicatrix
;
Cytochrome P-450 CYP2C19
;
Endoscopy
;
Genotype
;
Humans
;
Multivariate Analysis
;
Prospective Studies
;
Proton Pump Inhibitors
;
Proton Pumps*
;
Protons*
;
Rabeprazole
;
Stomach Neoplasms
;
Stomach Ulcer*
;
Ulcer