With innovations of “Courses of Study” in high school, the number of medical students who have not studied biology has increased rapidly and has created problems for medical education. Therefore, we started a course entitled “Science for a Healthy Life” for medical school freshmen. In traditional lectures, students often lose interest and start talking among themselves. For these reasons, we introduced new interactive education techniques into lectures for “Science for a Healthy Life.” Most students were interested in the visual aids and the performance of simple experiments. The students could discuss subjects and present results. With these new educational techniques, most student learned actively and efficiently. Many students learned by themselves with visual aids and reference books outside class, for example, after school and during summer and winter vacation. Finally, we found no significant difference in examination results for “Science for a Healthy Life” between students who had studied biology in high school or those who had not.

1) In accordance with core curriculums, we have proceeded with the educational reform of biochemical experiments.
2) Before experiments, the young physicians told medical students about their experiences and the relations between the laboratory exercises and medical care.
3) We also attempted to clarify the objective assessment of laboratory exercise reports, and we performed a comprehensive evaluation of laboratory exercises with tutorials and a final examination.

The venerable drug colchicine has garnered significant recent attention due to its endorsement by the United States Food and Drug Administration as an anti-inflammatory medication for cardiovascular diseases. However, the administration of this drug at its minimal available dose of 0.5 mg has been associated with certain adverse reactions.Once colchicine is administered, the drug disappears from blood in a short time and distributes in the leukocytes for a certain period of time that elicits anti-inflammatory effect.Consequently, an in-depth comprehension of the pharmacokinetics of lower dosages within leukocytes assumes important for its broader application in routine clinical contexts. In this study, we present a comprehensive analysis of the pharmacological disposition of colchicine in the plasma, polymorphonuclear leukocytes, and mononuclear leukocytes among healthy Japanese male subjects, following both single and multiple oral administrations of 0.5 mg and 0.25 mg doses of colchicine. Our investigation reveals that colchicine persists within leukocyte populations even when administered at reduced dosages. The findings herein hold promise for mitigating the adverse effects associated with its use in the treatment of inflammatory cardiovascular disorders.