Abstract: Nitraria Sibirica Pall (NSP) is an annual plant of the family Zygophyllaceae that has been used for many diseases. The fruits of NSP have been used as a folk medicine for thousands of years in Mongolia and China. Numerous bioactive phytochemicals, such as flavonoids, alkaloids and glycosides, have been isolated and identified from NSP that are responsible alone or in combination for various pharmacological activities. However, to date, anti-nephrotoxicity effects of NSP on Gentamcin-induced animal models have not been investigated. Method: In the experimental design, 24 Wistar rats were randomly isolated into three groups such as control, gentamicin and NSP. The renal injury was modeled by intramuscular injection of Gentamicin for 5 consecutive days (150 mg/kg). The doses of 25 mg/kg of aqueous extract of NSP were administrated by oral gavages for 14 consecutive days in rats. At 14 days for the rest of them, serum samples were collected for renal function biochemical tests (Blood urea nitrogen, creatinine, creatinine clearance and glomerular filtration rate). Result: We demonstrated that treatment of NSP aqueous extract significantly reduced blood urea nitrogen (BUN), serum creatinine (Cr) levels and increased creatinine clearance, glomerular filtration rate (GFR) levels in Gentamicin-administrated rats. Conclusion These data suggested that NSP shown good effect for anti-inflammatory of kidney.

Introduction: Tribulus terrestris L. (TTL) is an annual plant of the family Zygophyllaceae that has been used for many diseases including urinary tract diseases. The fruits and roots of TTL have been used as a folk medicine for thousands of years in Mongolia, China, Iraq, India, Sudan and Pakistan. Numerous bioactive phytochemicals, such as saponins, flavonoids, alkaloids and glycosides, have been isolated and identified from TTL that are responsible alone or in combination for various pharmacological activities. However, to date, the nephroprotective effects of TTL on cisplatin-induced animal models have not been investigated. Purpose: The present work aimed to investigate the protective effects of different doses of Tribulus terrestris L. (TTL) against cisplatin-induced nephrotoxicity in mice. Materials and methods: The renal injury was modeled by intraperitoneal injection of cisplatin for 5 consecutive days (5 mg/kg). Nephroprotection of TTL was investigated by oral administration of different doses of TTL aqueous extract at a daily dose of 20 mg/kg and 40 mg/kg for 14 consecutive days, starting 7 days prior to cisplatin administration. Results: We demonstrated that pretreatment with different doses of TTL aqueous extract significantly reduced blood urea nitrogen (BUN) and serum creatinine (Cr) levels and histophatological changes observed in cisplatin-administrated mice. Conclusion These data suggested that TTL might be a potential candidate for neoadjuvant chemotherapy of cisplatin. The dose of TTL 40 mg/kg was the most effective.

Introduction: Since 1993, the Inula helenium L. plant has been planted in the production area (Bulgan Province, Dashinchilen Sum) of the Traditional Hatchery Science and Production Corporation’s medicinal plant introduction and cultivation experience. At the Drug Research Institute, there is also a botanical institute for medicinal plants where it is grown. In traditional Mongolian medicine, the roots and rhizomes of Inula helenium L. are used to reduce inflammation, boost immunity, enhance hunger, and improve intestinal motility. Inula helenium L. roots and rhizomes contain biologically active compounds such as monoterpenes, sesquiterpenes, phenols, flavonoids, and polysaccharides. Methods: The roots and rhizomes of Inula helenium L. were extracted with water and 70% ethanol at the following ratios 1:10 (2% of WAC), 1:8, and 1:6 by partial maceration at 700C for 2 hours each, extracted and concentrated. The dry extract was obtained by the spray drying procedure. High-performance liquid chromatography for determining the content of alantolactone, thin-layer chromatography for qualitative analysis. Spectrophotometer for determining the content of polyphenolic compounds, colored compounds with Folin-Ciocalteu reagent for qualitative analysis. Spectrophotometer for determining the content of inulin, and colored compounds with phenol and sulfuric acid solutions for qualitative analysis. Conclusion In determining the content of polyphenolic compounds, inulin, and alantolactone in the dry extract taken from the roots and rhizomes of cultivated Inula helenium L., the content of polyphenolic compound in dry extract A was 2.50±0.08%, and alantolactone was 1.39±0.11% in the raw material of the plant, while B dry the extract had a high concentration of inulin of 58.51±0.66%.