This project was aimed to develop a simple, convenient and reliable computer image processing software for the measurement of lens dimensions, including the radius of curvature of anterior lens surface (RCALS), the radius of curvature of posterior lens surface (RCPLS) and the lens volume (LV). On the basis of lens images captured by B ultrasound, our computer software was designed to calculate the three parameters of lens in accordance to geometry principle. This software comprises Program I and Program II, and they both possess different calculation methods. Then they were used in a group of normal volunteers who were recruited via randomization and the outcomes were compared. The results showed that the two programs were developed successfully, and the outcomes of RCALS, RCPLS and LV calculated by the two programs were similar. The standard deviation of Program II is smaller than that of Program I. The computer software for calculating RCALS, RCPLS and LV was characterized by scientific design and easy-to-use. In respect of calculating repetition, Program II was better than Program I, and it possesses prosperous prospect in terms of clinical research and application.
Adult ; Aged ; Female ; Humans ; Image Processing, Computer-Assisted ; methods ; Lens, Crystalline ; anatomy & histology ; diagnostic imaging ; Male ; Mathematical Computing ; Middle Aged ; Optics and Photonics ; Refraction, Ocular ; Software ; Ultrasonography

Objective To establish the diagnostic criteria for polypoidal choroidal vasculopathy (PCV) based on spectral-domain optical coherence tomography (SD OCT) by evaluating the sensitivity and specificity of SD OCT in differentiating PCV from wet age-related macular degeneration (wAMD).Methods The clinical data were reviewed for 62 patients (63 eyes) with the initial diagnosis of PCV or wAMD between August,2012 and June,2016.Twenty-four patients (25 eyes) were diagnosed to have PCV and 38 (38 eyes) had wAMD based on findings by fundus photography,fluorescein angiography (FFA) and indocyanine green angiography (ICGA).Among the 6 features of SD OCT,namely a sharp RPED peak,double-layer sign,multiple RPED,an RPED notch,a hyporeflecfive lumen representing polyps,and hyperreflecfive intraretinal hard exudates,findings of the first two features and at least one of the other features sufficed the diagnosis of PCV;in the absence of the first two features,the diagnosis of PCV was also made when at least 3 of the other features were present simultaneously.The sensitivity and specificity of SD OCT-based diagnosis were estimated by comparison with the gold standard ICGA-based diagnosis.Results In the 25 eyes with an established diagnosis of PCV,23 eyes (92.0％) met the diagnostic criteria based on SD OCT findings;in the 38 eyes with the diagnosis of wAMD,only 4 eyes (10.5％) met the criteria.The sensitivity and specificity of SD OCT-based diagnosis of PCV was 92.0％ and 89.5％,respectively.Conclusions We established the diagnostic criteria for PCV based on SD OCT findings with a high sensitivity and specificity.SD OCT shows a strong capacity for differentiating PCV from wAMD.

Objective To establish the diagnostic criteria for polypoidal choroidal vasculopathy (PCV) based on spectral-domain optical coherence tomography (SD OCT) by evaluating the sensitivity and specificity of SD OCT in differentiating PCV from wet age-related macular degeneration (wAMD).Methods The clinical data were reviewed for 62 patients (63 eyes) with the initial diagnosis of PCV or wAMD between August,2012 and June,2016.Twenty-four patients (25 eyes) were diagnosed to have PCV and 38 (38 eyes) had wAMD based on findings by fundus photography,fluorescein angiography (FFA) and indocyanine green angiography (ICGA).Among the 6 features of SD OCT,namely a sharp RPED peak,double-layer sign,multiple RPED,an RPED notch,a hyporeflecfive lumen representing polyps,and hyperreflecfive intraretinal hard exudates,findings of the first two features and at least one of the other features sufficed the diagnosis of PCV;in the absence of the first two features,the diagnosis of PCV was also made when at least 3 of the other features were present simultaneously.The sensitivity and specificity of SD OCT-based diagnosis were estimated by comparison with the gold standard ICGA-based diagnosis.Results In the 25 eyes with an established diagnosis of PCV,23 eyes (92.0％) met the diagnostic criteria based on SD OCT findings;in the 38 eyes with the diagnosis of wAMD,only 4 eyes (10.5％) met the criteria.The sensitivity and specificity of SD OCT-based diagnosis of PCV was 92.0％ and 89.5％,respectively.Conclusions We established the diagnostic criteria for PCV based on SD OCT findings with a high sensitivity and specificity.SD OCT shows a strong capacity for differentiating PCV from wAMD.

OBJECTIVE: To evaluate the value of fundus autofluorescence (FAF) imaging combined with spectral domain optical coherence tomography (SD-OCT) in diagnosis, prognostic assessment and follow-up observation of acute Vogt-KoyanagiHarada (VKH) disease. METHODS: Clinical data were collected from 12 patients (23 eyes) with acute VKH disease treated in our hospital from May, 2018 to November, 2019, including detailed medical history, best corrected visual acuity (BCVA), and results of slit lamp biomicroscopy, fundus photography, SD-OCT, fundus fluorescein angiography (FFA) and FAF imaging.SDOCT and FAF imaging were repeated after a course of treatment and in follow-up examination, and the results were compared with those at the time of admission. RESULTS: VKH disease involved both eyes in 11 patients (91.7%).Fundus photography showed optic disc edema in 16 eyes (69.6%), and multiple retinal neuroepithelial detachment was detected by SD-OCT in all the involved eyes (100%).IN all the eyes, FFA revealed small and dense fluorescein leakage in the early stage and fluorescein accumulation in advanced stages of VHK disease to form multiple dye pooling in the areas of serous detachment.Hyperauto fluorescence was a common finding in FAF imaging (100%), and the area involved was consistent with that of fluorescein accumulation shown by FAF imaging.Ten eyes (43.5%) showed patches of relative hypoautofluorescence in the hyperauto fl uorescence areas, and granular hyperauto fl uorescence was found in the lesions in 4 eyes (17.4%).During the remission period of VKH disease, FAF imaging showed normal finding in 8 eyes (34.8%) and reduced areas (by 55.2%) and intensity (by 46.5%) of hyperautofluorescence in 9 eyes (39.1%).In 6 eyes (26.1%), only a few hyperautofluorescent spots scattered in the macula were observed.SD-OCT demonstrated significantly reduced (by 69.5% on average) or even disappearance of subretinal fluid in the eyes.The fluorescence intensity in FAF imaging showed a significant positive correlation with the volume of subretinal fluid detected by SD-OCT ( CONCLUSIONS The combination of fluorescein angiography, FAF imaging and SD-OCT can significantly improve the diagnostic accuracy of VKH disease.FAF imaging combined with SD-OCT provides an effective and noninvasive modality for evaluation of remission and monitoring the changes in VKH disease.
Acute Disease ; Fluorescein Angiography ; Follow-Up Studies ; Humans ; Retinal Detachment/diagnostic imaging* ; Tomography, Optical Coherence ; Uveomeningoencephalitic Syndrome/diagnostic imaging*