Objective To explore the clinical effect of misoprostol combined with oxytocin for preventing postpartum hemorrhage.Methods 120 cases of maternals were randomly divided into the observation group and control group,each group 60 cases.The control group were given oxytocin treatment,and the observation group based on the control group were given 200μg anal plug rectal misoprostol.The volume of postpartum hemorrhage were compared between the two groups.Results The postpartum hemorrhage volume of the observation group in postpartum 2h,postpartum 24h was (264.43 ± 21.72) ml,(413.37 ± 35.64) ml,respectively,and were significantly less than that of the control group [(328.36 ± 34.54) ml,(498.46 ± 46.62) ml] (t =12.54,12.63,all P ＜ 0.05) ; The rate of postpartum hemorrhage in the observation group was 15.00％,which was significantly lower than that in the control group (36.67％)(x2 =7.36,P ＜ 0.05).The neonatal asphyxia incidence in the observation group was 1.67％,which was lower than that in the control group (5.00％),but there was no statistically significant difference (x2 =0.26,P ＞0.05).Conclusion Misoprostol combined oxytocin can prevent postpartum hemorrhage and reduce the rate of postpartum hemorrhage.

Objective To research and analyze the correlation of TNF-αexpression and renal damage in gestational hypertension patients.Methods 60 patients with gestational hypertension were selected as study group.Meanwhile,59 healthy pregnant women were selected as control group.The TNF-α expression and renal function were tested and analyzed.Results The TNF-α expression in study group was (24.7 ± 5.6)μg/L,(12.1 ± 8.2)μg/L in control group (P ＜ 0.05).The serum creatinine in 29 patients in the study group was (317 ± 24) μmol/L,TNF-α (26.9± 1.6)μg/L.The serum creatinine in other 31 patients was (153 ± 18)μmol/L,TNF-α (21.7 ± 2.1)μg/L.The serum creatinine in control group was (56 ± 19) μmol/L,TNF-α (10.3 ±4.1) μg/L.There was a positive correlation between TNF-α expression and serum creatinine.Conclusion The TNF-α expression may be positively correlate with renal damage in gestational hypertension patients.

Objective To investigate the clinical application of pressure pulse band in placenta previa cesarean section hemorrhage.Methods 130 patients with placenta previa surgery bleeding were randomly divided into two groups.The control group received conventional treatment of oxytocin,and the observation group,on the basis of the control group,in cesarean section in placenta praevia fail to control bleeding and bleeding is excessive,may surround the cervix as possible by lower fastening pressure pulse band (i.e.both ligament below),rapid delivery of uterus in abdominal cavity,stop the bleeding.Results The average time to hemostasis and surgical time of the control group were significantly higher than those of the observation group(t =5.72,13.27,P ＜ 0.05).The average blood loss,blood transfusion were significantly higher than those of the observation group (t =14.37,10.45,P ＜ 0.05).The number of transfusion was significantly higher than that of the observation group (x2 =15.93,P ＜ 0.05).There was no death case.Conclusion In placenta previa cesarean section,the application of pressure pulse band can be quickly and effectively reduce the bleeding during operation and easy to master.

Objective:To observe the e ect of Gongqing grain on the expression of Caspase-3 and Caspase-8 in the human's villi and decidua in early pregnancy teminated by drug,discuss the mechanism of Gongqing grain protecting and treating hemorrhage after drug-induced abortion.Methods:180 patients were divided into three groups randomly:Gongqing grain group,Qianzhi capsule group and drug abortion group,and arti cial abortion group(n=60)was set.The immunohistochemical method was used to observe the expressions of Caspase-3、8 in the villi and deciduas.Results:The level of Caspase-3、8 in the villi and deciduas decreased more signi cantly in Gongqing grain group than the other three groups(P

Objective To explore the risk factors for retinopathy in patients with metabolic syndrome.Methods A total of 120 patients with metabolic syndrome admitted to Nanyang Central Hospital from July 2021 to July 2023 were selected as the research subjects,and the patients were categorized into the retinopathy group(n=58)and the non-retinopathy group(n=62)according to the results of fundus examination.The clinical data of patients with metabolic syndrome in both groups were collected and compared.10 mL of blood was collected from the elbow vein of patients in both groups,and the hemoglobin level was measured using a fully automatic blood cell analyzer.The levels of total cholesterol(TC),triacylglycerol(TG),high density lipoprotein-cholesterol(HDL-C),and low density lipoprotein-cholesterol(LDL-C)in the two groups were measured using an automatic biochemical analyzer.The glycosylated hemoglobin(HbA1c)level was determined by high-performance liquid chromatography.The estimated glomerular filtration rate(eGFR)was calculated using the chronic kidney disease epidemiology collaboration equation.Multivariate logistic regression analysis was used to determine the risk factors for retinopathy in patients with metabolic syndrome.Results There were no statistically significant differences in smoking history,drinking history,usage rates of hypoglycemic drugs,lipid-lowering drugs and antihypertensive drugs,systolic blood pressure,cataract,TC,TG,HDL-C,LDL-C,and eGFR between the two groups(P＞0.05).The age,disease duration,insulin usage rate,diastolic blood pressure,HbA1c level,and anemia incidence of patients in the retinopathy group were significantly higher than those in the non-retinopathy group(P＜0.05).Multivariate logistic regression analysis showed that older age,longer disease duration,insulin injection,higher diastolic blood pressure,higher HbA1c level,and lower hemoglobin level were independent risk factors for retinopathy in patients with metabolic syndrome(P＜0.05).Conclusion Old age,long disease duration,insulin injection,high systolic blood pressure,high HbA1c level,and low hemoglobin level are independent risk factors for retinopathy in patients with metabolic syndrome.

Objective To investigate the risk factors and risk prediction model of retinal detachment in patients with myopia.Methods The clinical data of myopic patients treated in our hospital from January 2021 to December 2023 were retrospectively analyzed.A total of 128 patients(128 eyes)with myopic retinal detachment who met the requirements were selected as the retinal detachment group,and 128 myopic patients(128 eyes)without retinal detachment were selected as the control group.The clinical data of patients in the two groups were collected and compared,including age,gender,di-opter,education level,affected side,whether to bear load or not,whether to vibrate or not,whether to have cataract or not,whether to have asthenopia or not,blood pressure,history of diabetes,history of ocular trauma,history of ophthal-mic surgery,and retinal thickness.Risk factors related to retinal detachment in myopia were determined through the multi-variate logistic regression analysis,and based on these factors,the risk prediction model was established.The receiver op-erating characteristic(ROC)curve was used to evaluate the predictive value of the model.Results The age,diopter,systolic blood pressure,cataract incidence,asthenopia incidence,ocular trauma and ophthalmic surgery rates of myopic patients in the retinal detachment group were significantly higher than those in the control group(all P＜0.05).The retinal thickness and choroidal thickness of myopic patients in the retinal detachment group were significantly smaller than those in the control group(both P＜0.05).The risk factors for retinal detachment in myopic patients were older age,higher diopter(absolute value),accompanied by ocular diseases or discomfort such as cataract,asthenopia and ocular trauma,thinner choroid,and thinner retina(all OR＞1,P＜0.05).The areas under the ROC curve(0.95CI)for predication of retinal de-tachment based on age,ocular disease or discomfort,diopter,choroidal thickness,and retinal thickness alone and their combination were 0.668(0.382-0.936),0.645,0.676(0.407-0.942),0.731(0.503-0.933),0.745(0.499-0.983),and 0.844(0.692-0.983),respectively.The area under the curve(0.844),sensitivity,specificity,and accuracy of the prediction model based on the combination of the five indicators were higher,indicating that this model had a better predic-tion effect.Conclusion The risk factors for retinal detachment in myopic patients are older age,higher diopter(abso-lute value),accompanied by ocular diseases or discomfort such as cataract,asthenopia and ocular trauma,thinner cho-roid,and thinner retina.The risk prediction model constructed based on these factors has a high evaluation effect.