Objective To explore the clinical effect of misoprostol combined with oxytocin for preventing postpartum hemorrhage.Methods 120 cases of maternals were randomly divided into the observation group and control group,each group 60 cases.The control group were given oxytocin treatment,and the observation group based on the control group were given 200μg anal plug rectal misoprostol.The volume of postpartum hemorrhage were compared between the two groups.Results The postpartum hemorrhage volume of the observation group in postpartum 2h,postpartum 24h was (264.43 ± 21.72) ml,(413.37 ± 35.64) ml,respectively,and were significantly less than that of the control group [(328.36 ± 34.54) ml,(498.46 ± 46.62) ml] (t =12.54,12.63,all P ＜ 0.05) ; The rate of postpartum hemorrhage in the observation group was 15.00％,which was significantly lower than that in the control group (36.67％)(x2 =7.36,P ＜ 0.05).The neonatal asphyxia incidence in the observation group was 1.67％,which was lower than that in the control group (5.00％),but there was no statistically significant difference (x2 =0.26,P ＞0.05).Conclusion Misoprostol combined oxytocin can prevent postpartum hemorrhage and reduce the rate of postpartum hemorrhage.

Objective To research and analyze the correlation of TNF-αexpression and renal damage in gestational hypertension patients.Methods 60 patients with gestational hypertension were selected as study group.Meanwhile,59 healthy pregnant women were selected as control group.The TNF-α expression and renal function were tested and analyzed.Results The TNF-α expression in study group was (24.7 ± 5.6)μg/L,(12.1 ± 8.2)μg/L in control group (P ＜ 0.05).The serum creatinine in 29 patients in the study group was (317 ± 24) μmol/L,TNF-α (26.9± 1.6)μg/L.The serum creatinine in other 31 patients was (153 ± 18)μmol/L,TNF-α (21.7 ± 2.1)μg/L.The serum creatinine in control group was (56 ± 19) μmol/L,TNF-α (10.3 ±4.1) μg/L.There was a positive correlation between TNF-α expression and serum creatinine.Conclusion The TNF-α expression may be positively correlate with renal damage in gestational hypertension patients.

Objective To investigate the clinical application of pressure pulse band in placenta previa cesarean section hemorrhage.Methods 130 patients with placenta previa surgery bleeding were randomly divided into two groups.The control group received conventional treatment of oxytocin,and the observation group,on the basis of the control group,in cesarean section in placenta praevia fail to control bleeding and bleeding is excessive,may surround the cervix as possible by lower fastening pressure pulse band (i.e.both ligament below),rapid delivery of uterus in abdominal cavity,stop the bleeding.Results The average time to hemostasis and surgical time of the control group were significantly higher than those of the observation group(t =5.72,13.27,P ＜ 0.05).The average blood loss,blood transfusion were significantly higher than those of the observation group (t =14.37,10.45,P ＜ 0.05).The number of transfusion was significantly higher than that of the observation group (x2 =15.93,P ＜ 0.05).There was no death case.Conclusion In placenta previa cesarean section,the application of pressure pulse band can be quickly and effectively reduce the bleeding during operation and easy to master.

Objective:To observe the e ect of Gongqing grain on the expression of Caspase-3 and Caspase-8 in the human's villi and decidua in early pregnancy teminated by drug,discuss the mechanism of Gongqing grain protecting and treating hemorrhage after drug-induced abortion.Methods:180 patients were divided into three groups randomly:Gongqing grain group,Qianzhi capsule group and drug abortion group,and arti cial abortion group(n=60)was set.The immunohistochemical method was used to observe the expressions of Caspase-3、8 in the villi and deciduas.Results:The level of Caspase-3、8 in the villi and deciduas decreased more signi cantly in Gongqing grain group than the other three groups(P