OBJECTIVE:To provide advices on how to apply to the theory of customer relationship management in retail drugstores.METHODS:The theory of customer relationship management was briefly expounded and its application in the real management of drugstores was analyzed.RESULTS&CONCLUSION:Only after the retail drugstore putting the ideas of customer relationship management into their everyday work according to their own features can their function brought into full play.

Objective To observe the diagnostic value and the safety of fiberoptic bronchoscopy in the children with airway malformations. Methods The test results and clinical data of 106 cases of bronchoscopy infants of our hospital from June 2011 to December 2013 were retrospectively analyzed. And the results and clinical date of 34 cases of chil-dren with airway malformations of the inspection were restrospectively analyzed. Results Of all 106 cases, there were 34 cases with airway malformations(32%),including 2 cases with laryngeal cyst,5 cases with epiglottic cartilage softening,20 cases with tracheobronchomalacia, 3 cases with tracheobronchial, 3 cases with anomalous origin and stenosis of bronchus,l cases with tracheo-esophageal fistula. Conclusion The fiberoptic bronchoscopy plays an important role in diagnosis of children with airway malformations. It can degrade the rate of clinical misdiagnosis and missed diagnosis in the children with respiratory diseases and is worth to be widely implemented.

Objective: Predefining the most effective treatment for patients with depressive disorders remains a problem. We will examine the differential brain regions of gray matter (GM) in major depressive disorder (MDD) patients and the relationship between changes in their volume and the efficacy of early antidepressant treatment using magnetic resonance imaging (MRI). Methods: 159 never-medicated patients with first-episode MDD and 53 normal control subjects (NCs) were enrolled. The brains were scanned by MRI and measured with the 17-item Hamilton Depression Rating Scale (HAMD-17) at baseline and after 2 weeks of treatment with selective serotonin reuptake inhibitor (SSRI)s, and the non-responder group and responder group were obtained. The patients were analyzed by voxel-based morphological (VBM) and SPSS software. Receiver operator characteristics (ROC) analysis was performed for the difference between the responder group and the non-responder group in the differential brain regions, and Pearson correlations were computed between volume size and HAMD score reduction rate. Results: Smaller GM volume of the right superior temporal gyrus (STG), and the orbital parts of the right medial frontal gyrus and right inferior frontal gyrus were observed in MDD versus the NCs. The non-responder group demonstrated a significant volume reduction at the right STG compared with the responders, but no corresponding change in orbital part of right medial frontal gyrus and right inferior frontal gyrus. ROC analysis showed that Accuracy=71.2%. There was a positive correlation between the STG gray matter volume and the HAMD-17 score reduction rate (r=0.347, p=0.002). Conclusion The study results confirmed the local changes in brain structure in MDD and may initially predict the early treatment response produced by SSRIs as antidepressants.

At present , laboratory medicine has become one of the fastest growing subjects in the field of medicine.The development of laboratory medicine directly led to the improvement of diagnosis and the increase of test methods in clinic .The data of project applications and grants of the National Natural Science Foundation of China in the field of laboratory medicine from 2014 to 2017 were reviewed and summarized.The future prospect was also analyzed to provide references for related researchers in this field .

Objective To investigate the relationship between the right-to-left shunt(RLS)detected with contrast-enhanced transcranial Doppler (c-TCD) and recurrent stroke in patients with cryptogenic stroke.Methods The consecutive patients w ith ischemic stroke w ere enrol ed. The patients w ith cryptogenic stroke w ere screened according to the TOAST criteria. They w ere divided into either a RLS positive group or a RLS negative group according to the c-TCD findings, and then they w ere fol ow ed up for a period of one year. They w ere also divided into a recurrent group and a non-recurrent group according to w hether they had recurrence or not. Results A total of 118 patients w ith cryptogenic ischemic stroke w ere enrol ed, including 46 in the RLS positive group, 72 in the RLS negative group, 10 in the recurrent group, and 108 in the non-recurrent group. There w ere no significant differences in demographic and baseline data betw een the RLS negative group and the RLS positive group. There w ere significant differences in RLS positive rate (7/10 vs.39/108; P=0.046) and proportion of patients with server RLS (2/10 vs.1/108; P=0.019) betw een the recurrent group and the non-recurrent group. Multivariate logistic regression analysis show ed that the positive RLS w as an independent predictor of recurrent stroke (odds ratio 4.896, 95% confidence interval 1.135-21.120;P=0.033). Conclusions The positive RLS may be an independent risk factor for the recurrence in patients w ith cryptogenic ischemic stroke.

Objective:To study the radiation dose rate and effective dose in ambient environment due to 125I seed implantation in the treatment of the patients suffering abdominal and pelvic tumors, so as to provide reference for occupational protection of different groups. Methods:Within 24 hours after operation, the radiation dose rate to 42 patients with abdominal and pelvic tumor with 125I seed implantation was monitored by using pocket dosimeter. The relationships between the total activity in the implanted particles and the measured dose rate, as well as between the implanted depth and the dose rate under the standard activity, were obtained by curve fitting. According to the formula, the relationship between the dose rate and the warning time was calculated. Results:The dose rates at 30 cm, 50 cm and 100 cm of vertical particle implantation site were (6.92±2.87), (4.10±1.62) and (1.30±0.48) μSv/h, respectively ( χ2=73.71, P<0.05). The dose rates on the left and right sides were (0.378±0.156) and (0.384±0.153) μSv/h at 30 cm, (0.170±0.089) and (0.17±0.086) μSv/h at 50 cm, (0.039 ±0.014) and (0.043±0.017) μSv/h at 100 cm, respectively ( χ2=76.19, 76.33, P<0.05). There was a linear relationship between the dose rate at the vertical particle implantation site and the total activity in the implanted particles, and between the dose rate and the implantation depth under the standard activity. The relationship between the warning time and the dose rate to adults in the same bed, co-workers, minors in the same bed and pregnant women were as follows: t ( d)=-106.616+ 83.779ln D( t), t ( d)=26.556+ 85.933ln D ( t), t( d)=3.088+ 85.017ln D( t). Conclusions:After 125I seed implantation, the radiation dose in the ambient environment is low, ensuring the radiation safety; and the measured dose rate decreases with the decrease in the total activity in the implanted particle and the increase in the implantation depth; at the same time, the warning time for different groups is calculated according to the measured dose rate or the total activity in the implanted particle and the depth of the implanted particle, so as to carry out individualized protection.

The characteristics and principles of acupoint selection in auricular plaster therapy for hypertension were explored. By searching CNKI (search time from 1950 to November of 2015), VIP database (search time from 1989 to November of 2015) and WanFang Database (search time from 1983 to November of 2015), the clinical research literature regarding auricular plaster therapy for hypertension was collected, and frequency statistics method was used for analysis. As a result, totally 117 articles were included. The auricular points with frequency from high to low were Jiangyagou, Shenmen (TF), Gan (CO), Xin (CO), Shen (CO), Jiaogan (AH), Pizhixia (AT), Jiangyadian and Neifenmi. The TCM syndromes with frequency from high to low were excessive accumulation of phlegm-dampness syndrome, upper hyperactivity of liversyndrome,deficiency andhyperactivity syndrome and excessive liver-fire syndrome. In conclusion, based on cross-reference of TCM and modern medicine combination ofand meridians differentiation and valuing the auricular points from clinical experience, the auricular plaster therapy for hypertension was characterized with "treating the principal and subordinate symptoms simultaneously and respectively" and "differentiation-based selection of auricular points to regulate", which could fully take the anti-hypertension advantages of non-pharmacotherapy.

To summarize the projects granted by National Natural Science Foundation of China related to tumor biomarkers in laboratory medicine from 2010 to 2018. The projects are categorized and analyzed according to tumor classification, biochemical properties of biomarkers. What′s more, characters of granted projects of tumor biomarkers in recent 9 years are summarized and development trends are pointed out.

Regarding to the sharply increased applications and relatively lower rate of successful funding for major projects in the fields of Critical Care/Wounds and Injuries/Burns/Plastic Surgery from the National Natural Science Foundation of China in recent years, the author summarized the funded projects in this specific field from 2014 to 2018, discussed the characteristics and trends of these applications and grants, and summarized the hotspot issues and frontier researches so as to help the applicants in the future.