With the development of oncology and neuroscience, cancer-neuroscience, as their interdisciplinary subject, has also attracted widespread scholars' attention in recent years. People have gradually realized that neurons are involved in the formation of tumor microenvironment and affect the initiation and progression of tumor. Similarly, tumor can also cause nervous system remodeling and dysfunction. The relationship between glioma, as the most common malignant tumor in the central nervous system, and neurons have gained a new understanding. This review discusses the latest advance in cancer-neuroscience in the study of gliomas, and systematically reviews the mechanism of interaction between neurons and glioma cells.